DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIIIC160 and polr2a

DIOPT Version :9

Sequence 1:	NP_001096987.2	Gene:	RpIIIC160 / 32524	FlyBaseID:	FBgn0030687	Length:	1383	Species:	Drosophila melanogaster
Sequence 2:	XP_005156282.1	Gene:	polr2a / 553347	ZFINID:	ZDB-GENE-041008-78	Length:	1965	Species:	Danio rerio

Alignment Length:	1552	Identity:	512/1552 - (32%)
Similarity:	762/1552 - (49%)	Gaps:	272/1552 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ISHVQFGISGADEIQQEALVR--IISKNLYQAQRQPVPYGVLDRRMGISTKDAMCETCGQGLNEC 77
            |..||||:...||:::.::..  |......:..| |...|::|.|.|:..:...|:||...:.||
Zfish    16 IKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGR-PKLGGLMDPRQGVIERSGRCQTCAGNMTEC 79

  Fly    78 IGHFGYLDLALPVFHIGHFRSTINILQMICKVCAHVML---KPEDRQLYEKKLHNPNFSYLGKKA 139
            .||||:::||.||||:|.....:.:|:.:|..|:.:::   .|:.:.:..|....|.     |:.
Zfish    80 PGHFGHIELAKPVFHVGFITKIMKVLRCVCFFCSKLLVDANNPKIKDILTKSKGQPR-----KRL 139

  Fly   140 LHVQMLAKAKKVTKCPHCGSPNGGVKKGPGLLKILHDPYKGRKMDSLFTSNMNEMLRSTQTNRDL 204
            .||..|.|.|.:.:                         .|.:||:.|.....|       :.|:
Zfish   140 THVYDLCKGKNICE-------------------------GGEEMDNKFGVEQPE-------SEDI 172

  Fly   205 NSTLG-------------------------NYSTAEE---LTPLMVLDLFEQIPQRDVALLGMCS 241
            ....|                         |..:.|:   |:|..|.::|::|...:..:|||..
Zfish   173 TKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRIADEEDIILGMDP 237

  Fly   242 HDAHPKHLIVTRVFVPPACIRPSVLSEVKAGTTEDDLTMKQSEILLINDVIQRHMATGGKIELIH 306
            ..|.|:.:|||.:.|||..:||:|:.:..| ..:||||.|.::|:.||:.::|:..:|....:|.
Zfish   238 KYARPEWMIVTVLPVPPLAVRPAVVMQGSA-RNQDDLTHKLADIVKINNQLKRNEQSGAAAHVIA 301

  Fly   307 EDWDFLQLHVALYFHSEISGIPINMAPK-KTTRGIVQRLKGKQGRFRCNLSGKRVDFSGRTVISP 370
            ||...||.|||....:|:.|:|..|... :..:.|.||||||:||.|.||.|||||||.||||:|
Zfish   302 EDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSIKQRLKGKEGRVRGNLMGKRVDFSARTVITP 366

  Fly   371 DPNLMINQVGVPVRVAKILTYPERVNPANIRHMRELVRNGPSMHPGANYVQQRGSSFKKYLAYGN 435
            ||||.|:|||||..:|..:|:||.|.|.||..::||||.|.|.:|||           ||:...|
Zfish   367 DPNLQIDQVGVPRSIAANMTFPEIVTPFNIDRLQELVRRGNSQYPGA-----------KYIIRDN 420

  Fly   436 REKV---------AQELKCGDVVERHLRDGDIVLFNRQPSLHKMSIMCHRAKVQPQRTFRFNECA 491
            .:::         ...|:.|..||||:.||||::|||||:|||||:|.||.::.|..|||.|...
Zfish   421 GDRIDLRFHPKPSDLHLQIGYKVERHMCDGDIIVFNRQPTLHKMSMMGHRVRILPWSTFRLNLSV 485

  Fly   492 CTPYNADFDGDEMNLHLPQTEEARAEALILMGNQSNLVTPKNGEILIAATQDFITGGYLLTQKEV 556
            .||||||||||||||||||:.|.|||...|......:|||::...::...||.:|.....|:::|
Zfish   486 TTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDV 550

  Fly   557 FLTKEEAMQLAACFLANEDSTMHIKLPPPALLKPRRLWTGKQMFSLLMRPNDDSQVRLNMVNKGR 621
            ||.:.|.|.| ..||:..|.    |:|.||:||||.||||||:|||:: |...:.:|.:..:...
Zfish   551 FLERGEVMNL-LMFLSTWDG----KVPQPAILKPRPLWTGKQIFSLII-PGHINAIRTHSTHPDE 609

  Fly   622 N----YTRNKDLCSNDSWIHIRNSELMCGVMDKATMG--SGTKQCIFYLLLRDFGESHATKAMWR 680
            .    |   |::...|:.:.:.|.||:.|::.|.::|  :|:...|.||   :.|..........
Zfish   610 EDSGPY---KNISPGDTKVIVENGELIMGILCKKSLGTSAGSLVHISYL---EMGHDITRLFYSN 668

  Fly   681 LARIASYFLQNRGFSFGISDVTPSKKLLQHKELLLNNGYAKCNEYIELLKAGTLQCQPGCTPEET 745
            :..:.:.:|...|.|.||.|....|...|..:..:........|.||......|:..||.|..:|
Zfish   669 IQTVVNNWLLIEGHSIGIGDSIADKATYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQT 733

  Fly   746 LESVMLRELSAIREQAAKTCFAELHPTNSALIMALSGSKGSNINISQMIACVGQQAISGKRVPNG 810
            .|:.:.|.|:..|::...:....|...|:...|.::|||||.|||||:||.||||.:.|||:|.|
Zfish   734 FENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVAGSKGSKINISQVIAVVGQQNVEGKRIPFG 798

  Fly   811 FENRALPHFERHSAIPAARGFVQNSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYLQRRLVK 875
            |::|.||||.:....|.:||||:||:.:||||||||||.|.|||||:|||||||||||:||||:|
Zfish   799 FKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRRLIK 863

  Fly   876 CLEDLVVHYDGTVRNAVNEMVDTIYGGDGLDPVSMETRN----KPVDLVHQ------YDNLRA-- 928
            .:|.::|.||.||||::|::|...||.|||...::|.:|    ||.....:      |.|.||
Zfish   864 SMESVMVKYDATVRNSINQVVQLRYGEDGLAGEAVEFQNMATLKPSHKAFEKKFKFDYANERALR 928

  Fly   929 ---QHPQGKDRPLNAEEMSEALETLLRTPEFAEARDD---------------------------- 962
               |....||...||...| :||.     ||.:.|:|
Zfish   929 RTLQEDVVKDVMTNAHVQS-SLER-----EFEKMREDREILRAIFPTGDSKVVLPCNLARMIWNA 987

  Fly   963 ---FKLDVR-----------NHINTVSKRI------GQLQKRYEKCIDLCHQIE-----C----- 997
               |:::.|           :.:..:||::      .||.::.::...|...|.     |
Zfish   988 QKIFRINPRAPTDLNPARVVDGVKELSKKLVIVNGDDQLSRQAQENATLLFNIHLRSTLCSKRMT 1052

  Fly   998 ----LTTEQLLQFVRRINDRYNRAVTEPGTAVGAIAAQSIGEPGTQMTLKTFHFAGVASMNITQG 1058
                |:||.....:..|..::|:::..||..|||:||||:|||.|||||.|||:|||::.|:|.|
Zfish  1053 EEFRLSTEAFDWLLGEIETKFNQSIAHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLG 1117

  Fly  1059 VPRIVEIINATKTISTPIITAEL--ENCHSMEFARQVKARIEKTTLAELSSYVEVVCGP------ 1115
            |||:.|:||.:|...||.:|..|  :.....|.|:.:..|:|.|||.::::...:...|
Zfish  1118 VPRLKELINISKRPKTPSLTVFLLGQAARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQNTV 1182

  Fly  1116 ----------YSCYLAIGVDMARIKLLGLHIDLDTIVFSILKSRMRVKPTQVEVVASQ------- 1163
                      |  |.....|:.||....|.|:||       :..|..:...:|.:|.:
Zfish  1183 VTEDQEWVNVY--YEMPDFDVTRISPWLLRIELD-------RKHMTDRKLTMEQIAEKINAGFGD 1238

  Fly  1164 -----------SRIVVRVEATRT-------------------------STINAELARLALSLQNV 1192
                       .::|:|:....:                         |.:..::....:...:.
Zfish  1239 DLNCIFNDDNAEKLVLRIRIMNSDENKFQEDEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISK 1303

  Fly  1193 VVAGLPNIN--RAVIAVDDARQPPTYKLCIE--GYGLRDVIATYGVVGKRTRSNNICEIYQTLGI 1253
            |...||..:  :.:|..:|.......:..:|  |..|..|::...|...||.||:|.||:..|||
Zfish  1304 VYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGI 1368

  Fly  1254 EAARTIIMSEITEVMEGHGMSVDWRHIMLLASQMTARGEVLGITRHGLAKMRESVFNLASFEKTA 1318
            ||.|..:..|:..|:...|..|::||:.||...||.||.::.|||||:.:.........|||:|.
Zfish  1369 EAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGINRQDTGPLMKCSFEETV 1433

  Fly  1319 DHLFDAAYYGQTDAINGVSERIILGMPACIGTGIFKLLQQHE----DKQVPPIEPTI 1371
            |.|.:|:.:|::|.:.||||.|:||..|..|||.|.||...|    ..::|...|.|
Zfish  1434 DVLMEASSHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGI 1490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIIIC160	NP_001096987.2	PRK08566	13..919	CDD:236292	355/956 (37%)
		RNAP_III_RPC1_N	24..889	CDD:259847	336/913 (37%)
		RNA_pol_Rpb1_5	839..1304	CDD:282807	181/606 (30%)
		RNAP_III_Rpc1_C	1013..1353	CDD:132723	121/404 (30%)
polr2a	XP_005156282.1	PRK08566	16..892	CDD:236292	348/937 (37%)
		RNAP_II_RPB1_N	17..873	CDD:259848	337/917 (37%)
		RNA_pol_Rpb1_5	827..1425	CDD:282807	181/612 (30%)
		RNA_pol_Rpb1_6	893..1076	CDD:282801	35/188 (19%)
		RNAP_II_Rpb1_C	1055..1473	CDD:132720	128/426 (30%)
		Aft1_HRA	1494..1571	CDD:288619
		CTD	1506..1611	CDD:215026
		RCR	<1869..1948	CDD:304939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D591636at2759
OrthoFinder	1	1.000	-	-		FOG0000819
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100210
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820