DRSC/TRiP Functional Genomics Resources

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Protein Alignment RpIIIC160 and POLR2A

DIOPT Version :9

Sequence 1:NP_001096987.2 Gene:RpIIIC160 / 32524 FlyBaseID:FBgn0030687 Length:1383 Species:Drosophila melanogaster
Sequence 2:NP_000928.1 Gene:POLR2A / 5430 HGNCID:9187 Length:1970 Species:Homo sapiens


Alignment Length:1550 Identity:510/1550 - (32%)
Similarity:759/1550 - (48%) Gaps:289/1550 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 KKISHVQFGISGADEIQQEALVR--IISKNLYQAQRQPVPYGVLDRRMGISTKDAMCETCGQGLN 75
            :.|..||||:...||:::.::..  |......:..| |...|::|.|.|:..:...|:||...:.
Human    16 RTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGR-PKLGGLMDPRQGVIERTGRCQTCAGNMT 79

  Fly    76 ECIGHFGYLDLALPVFHIGHFRSTINILQMICKVCAHVML---KPEDRQLYEKKLHNPNFSYLGK 137
            ||.||||:::||.||||:|....|:.:|:.:|..|:.:::   .|:.:.:..|....|.     |
Human    80 ECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPK-----K 139

  Fly   138 KALHVQMLAKAKKVTKCPHCGSPNGGVKKGPGLLKILHDPYKGRKMDSLFTSNMNEMLRSTQTNR 202
            :..||..|.|.|.:.:                         .|.:||:.|.      :...:.:.
Human   140 RLTHVYDLCKGKNICE-------------------------GGEEMDNKFG------VEQPEGDE 173

  Fly   203 DLNSTLG-------------------------NYSTAEE---LTPLMVLDLFEQIPQRDVALLGM 239
            ||....|                         |..:.|:   |:|..|.::|::|...:..:|||
Human   174 DLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGM 238

  Fly   240 CSHDAHPKHLIVTRVFVPPACIRPSVLSEVKAGTTEDDLTMKQSEILLINDVIQRHMATGGKIEL 304
            ....|.|:.:|||.:.|||..:||:|:.:..| ..:||||.|.::|:.||:.::|:...|....:
Human   239 EPRYARPEWMIVTVLPVPPLSVRPAVVMQGSA-RNQDDLTHKLADIVKINNQLRRNEQNGAAAHV 302

  Fly   305 IHEDWDFLQLHVALYFHSEISGIPINMAPK-KTTRGIVQRLKGKQGRFRCNLSGKRVDFSGRTVI 368
            |.||...||.|||....:|:.|:|..|... :..:.:.||||||:||.|.||.|||||||.||||
Human   303 IAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSARTVI 367

  Fly   369 SPDPNLMINQVGVPVRVAKILTYPERVNPANIRHMRELVRNGPSMHPGANYVQQRGSSFKKYLAY 433
            :|||||.|:|||||..:|..:|:.|.|.|.||..::||||.|.|.:|||           ||:..
Human   368 TPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGA-----------KYIIR 421

  Fly   434 GNREKV---------AQELKCGDVVERHLRDGDIVLFNRQPSLHKMSIMCHRAKVQPQRTFRFNE 489
            .|.:::         ...|:.|..||||:.|||||:|||||:|||||:|.||.::.|..|||.|.
Human   422 DNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNL 486

  Fly   490 CACTPYNADFDGDEMNLHLPQTEEARAEALILMGNQSNLVTPKNGEILIAATQDFITGGYLLTQK 554
            ...||||||||||||||||||:.|.|||...|......:|||::...::...||.:|.....|::
Human   487 SVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKR 551

  Fly   555 EVFLTKEEAMQLAACFLANEDSTMHIKLPPPALLKPRRLWTGKQMFSLLM------------RPN 607
            :|||.:.|.|.| ..||:..|.    |:|.||:||||.||||||:|||::            .|:
Human   552 DVFLERGEVMNL-LMFLSTWDG----KVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPD 611

  Fly   608 DDSQVRLNMVNKGRNYTRNKDLCSNDSWIHIRNSELMCGVMDKATMG--SGTKQCIFYLLLRDFG 670
            |:.......::.|            |:.:.:.|.||:.|::.|.::|  :|:...|.||   :.|
Human   612 DEDSGPYKHISPG------------DTKVVVENGELIMGILCKKSLGTSAGSLVHISYL---EMG 661

  Fly   671 ESHATKAMWRLARIASYFLQNRGFSFGISDVTPSKKLLQHKELLLNNGYAKCNEYIELLKAGTLQ 735
            ..........:..:.:.:|...|.:.||.|.....|..|..:..:........|.||......|:
Human   662 HDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELE 726

  Fly   736 CQPGCTPEETLESVMLRELSAIREQAAKTCFAELHPTNSALIMALSGSKGSNINISQMIACVGQQ 800
            ..||.|..:|.|:.:.|.|:..|::...:....|...|:...|.:||:|||.|||||:||.||||
Human   727 PTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQ 791

  Fly   801 AISGKRVPNGFENRALPHFERHSAIPAARGFVQNSFYSGLTPTEFFFHTMAGREGLVDTAVKTAE 865
            .:.|||:|.||::|.||||.:....|.:||||:||:.:||||||||||.|.|||||:||||||||
Human   792 NVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAE 856

  Fly   866 TGYLQRRLVKCLEDLVVHYDGTVRNAVNEMVDTIYGGDGLDPVSMETRN----KPVDLVHQ---- 922
            |||:||||:|.:|.::|.||.||||::|::|...||.|||...|:|.:|    ||.:...:    
Human   857 TGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFR 921

  Fly   923 --YDNLRA-----QHPQGKDRPLNAEEMSEALETLLRTPEFAEARDD------------------ 962
              |.|.||     |....||...||...:| ||.     ||...|:|                  
Human   922 FDYTNERALRRTLQEDLVKDVLSNAHIQNE-LER-----EFERMREDREVLRVIFPTGDSKVVLP 980

  Fly   963 -------------FKLDVR-----------NHINTVSKRI------GQLQKRYEKCIDLCHQIEC 997
                         |.::.|           ..:..:||::      ..|.::.::...|...|..
Human   981 CNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHL 1045

  Fly   998 LTT--------------EQLLQFVRRINDRYNRAVTEPGTAVGAIAAQSIGEPGTQMTLKTFHFA 1048
            .:|              |.....:..|..::|:|:..||..|||:||||:|||.|||||.|||:|
Human  1046 RSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNTFHYA 1110

  Fly  1049 GVASMNITQGVPRIVEIINATKTISTPIITAEL--ENCHSMEFARQVKARIEKTTLAELSSYVEV 1111
            ||::.|:|.||||:.|:||.:|...||.:|..|  ::....|.|:.:..|:|.|||.::::...:
Human  1111 GVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAI 1175

  Fly  1112 VC--GPYSCYLA-----IGV-------DMARIKLLGLHIDLDTIVFSILKSRMRVKPTQVEVVAS 1162
            ..  .|.|..:|     :.|       |:|||....|.::||       :..|..:...:|.:|.
Human  1176 YYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELD-------RKHMTDRKLTMEQIAE 1233

  Fly  1163 Q------------------SRIVVRVEATRTSTINAELARLA----------------------- 1186
            :                  .::|:|:.     .:|::..::.                       
Human  1234 KINAGFGDDLNCIFNDDNAEKLVLRIR-----IMNSDENKMQEEEEVVDKMDDDVFLRCIESNML 1293

  Fly  1187 --LSLQNV-----VVAGLPNIN--RAVIAVDDARQPPTYKLCIE--GYGLRDVIATYGVVGKRTR 1240
              ::||.:     |...||..:  :.:|..:|.......:..:|  |..|..|::...|...||.
Human  1294 TDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTT 1358

  Fly  1241 SNNICEIYQTLGIEAARTIIMSEITEVMEGHGMSVDWRHIMLLASQMTARGEVLGITRHGLAKMR 1305
            ||:|.||:..|||||.|..:..|:..|:...|..|::||:.||...||.||.::.|||||:.:..
Human  1359 SNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQD 1423

  Fly  1306 ESVFNLASFEKTADHLFDAAYYGQTDAINGVSERIILGMPACIGTGIFKLLQQHE 1360
            .......|||:|.|.|.:||.:|::|.:.||||.|:||..|..|||.|.||...|
Human  1424 TGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAE 1478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RpIIIC160NP_001096987.2 PRK08566 13..919 CDD:236292 354/966 (37%)
RNAP_III_RPC1_N 24..889 CDD:259847 334/921 (36%)
RNA_pol_Rpb1_5 839..1304 CDD:282807 183/609 (30%)
RNAP_III_Rpc1_C 1013..1353 CDD:132723 126/407 (31%)
POLR2ANP_000928.1 RNAP_II_RPB1_N 19..876 CDD:259848 335/925 (36%)
Bridging helix 833..845 9/11 (82%)
RNA_pol_Rpb1_6 896..1079 CDD:398590 33/188 (18%)
RNAP_II_Rpb1_C 1058..1476 CDD:132720 131/429 (31%)
CTD 1491..1610 CDD:215026
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1546..1970
C-terminal domain (CTD), 52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN] 1593..1960
Herpes_BLLF1 <1854..>1959 CDD:282904
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D591636at2759
OrthoFinder 1 1.000 - - FOG0000819
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100210
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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