DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIIIC160 and Polr2a

DIOPT Version :9

Sequence 1:	NP_001096987.2	Gene:	RpIIIC160 / 32524	FlyBaseID:	FBgn0030687	Length:	1383	Species:	Drosophila melanogaster
Sequence 2:	XP_343923.3	Gene:	Polr2a / 363633	RGDID:	1587326	Length:	1970	Species:	Rattus norvegicus

Alignment Length:	1550	Identity:	510/1550 - (32%)
Similarity:	759/1550 - (48%)	Gaps:	289/1550 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KKISHVQFGISGADEIQQEALVR--IISKNLYQAQRQPVPYGVLDRRMGISTKDAMCETCGQGLN 75
            :.|..||||:...||:::.::..  |......:..| |...|::|.|.|:..:...|:||...:.
  Rat    16 RTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGR-PKLGGLMDPRQGVIERTGRCQTCAGNMT 79

  Fly    76 ECIGHFGYLDLALPVFHIGHFRSTINILQMICKVCAHVML---KPEDRQLYEKKLHNPNFSYLGK 137
            ||.||||:::||.||||:|....|:.:|:.:|..|:.:::   .|:.:.:..|....|.     |
  Rat    80 ECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPK-----K 139

  Fly   138 KALHVQMLAKAKKVTKCPHCGSPNGGVKKGPGLLKILHDPYKGRKMDSLFTSNMNEMLRSTQTNR 202
            :..||..|.|.|.:.:                         .|.:||:.|.      :...:.:.
  Rat   140 RLTHVYDLCKGKNICE-------------------------GGEEMDNKFG------VEQPEGDE 173

  Fly   203 DLNSTLG-------------------------NYSTAEE---LTPLMVLDLFEQIPQRDVALLGM 239
            ||....|                         |..:.|:   |:|..|.::|::|...:..:|||
  Rat   174 DLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGM 238

  Fly   240 CSHDAHPKHLIVTRVFVPPACIRPSVLSEVKAGTTEDDLTMKQSEILLINDVIQRHMATGGKIEL 304
            ....|.|:.:|||.:.|||..:||:|:.:..| ..:||||.|.::|:.||:.::|:...|....:
  Rat   239 EPRYARPEWMIVTVLPVPPLSVRPAVVMQGSA-RNQDDLTHKLADIVKINNQLRRNEQNGAAAHV 302

  Fly   305 IHEDWDFLQLHVALYFHSEISGIPINMAPK-KTTRGIVQRLKGKQGRFRCNLSGKRVDFSGRTVI 368
            |.||...||.|||....:|:.|:|..|... :..:.:.||||||:||.|.||.|||||||.||||
  Rat   303 IAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSARTVI 367

  Fly   369 SPDPNLMINQVGVPVRVAKILTYPERVNPANIRHMRELVRNGPSMHPGANYVQQRGSSFKKYLAY 433
            :|||||.|:|||||..:|..:|:.|.|.|.||..::||||.|.|.:|||           ||:..
  Rat   368 TPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGA-----------KYIIR 421

  Fly   434 GNREKV---------AQELKCGDVVERHLRDGDIVLFNRQPSLHKMSIMCHRAKVQPQRTFRFNE 489
            .|.:::         ...|:.|..||||:.|||||:|||||:|||||:|.||.::.|..|||.|.
  Rat   422 DNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNL 486

  Fly   490 CACTPYNADFDGDEMNLHLPQTEEARAEALILMGNQSNLVTPKNGEILIAATQDFITGGYLLTQK 554
            ...||||||||||||||||||:.|.|||...|......:|||::...::...||.:|.....|::
  Rat   487 SVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKR 551

  Fly   555 EVFLTKEEAMQLAACFLANEDSTMHIKLPPPALLKPRRLWTGKQMFSLLM------------RPN 607
            :|||.:.|.|.| ..||:..|.    |:|.||:||||.||||||:|||::            .|:
  Rat   552 DVFLERGEVMNL-LMFLSTWDG----KVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPD 611

  Fly   608 DDSQVRLNMVNKGRNYTRNKDLCSNDSWIHIRNSELMCGVMDKATMG--SGTKQCIFYLLLRDFG 670
            |:.......::.|            |:.:.:.|.||:.|::.|.::|  :|:...|.||   :.|
  Rat   612 DEDSGPYKHISPG------------DTKVVVENGELIMGILCKKSLGTSAGSLVHISYL---EMG 661

  Fly   671 ESHATKAMWRLARIASYFLQNRGFSFGISDVTPSKKLLQHKELLLNNGYAKCNEYIELLKAGTLQ 735
            ..........:..:.:.:|...|.:.||.|.....|..|..:..:........|.||......|:
  Rat   662 HDVTRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELE 726

  Fly   736 CQPGCTPEETLESVMLRELSAIREQAAKTCFAELHPTNSALIMALSGSKGSNINISQMIACVGQQ 800
            ..||.|..:|.|:.:.|.|:..|::...:....|...|:...|.:||:|||.|||||:||.||||
  Rat   727 PTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQ 791

  Fly   801 AISGKRVPNGFENRALPHFERHSAIPAARGFVQNSFYSGLTPTEFFFHTMAGREGLVDTAVKTAE 865
            .:.|||:|.||::|.||||.:....|.:||||:||:.:||||||||||.|.|||||:||||||||
  Rat   792 NVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAE 856

  Fly   866 TGYLQRRLVKCLEDLVVHYDGTVRNAVNEMVDTIYGGDGLDPVSMETRN----KPVDLVHQ---- 922
            |||:||||:|.:|.::|.||.||||::|::|...||.|||...|:|.:|    ||.:...:
  Rat   857 TGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFR 921

  Fly   923 --YDNLRA-----QHPQGKDRPLNAEEMSEALETLLRTPEFAEARDD------------------ 962
              |.|.||     |....||...||...:| ||.     ||...|:|
  Rat   922 FDYTNERALRRTLQEDLVKDVLSNAHIQNE-LER-----EFERMREDREVLRVIFPTGDSKVVLP 980

  Fly   963 -------------FKLDVR-----------NHINTVSKRI------GQLQKRYEKCIDLCHQIEC 997
                         |.::.|           ..:..:||::      ..|.::.::...|...|..
  Rat   981 CNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHL 1045

  Fly   998 LTT--------------EQLLQFVRRINDRYNRAVTEPGTAVGAIAAQSIGEPGTQMTLKTFHFA 1048
            .:|              |.....:..|..::|:|:..||..|||:||||:|||.|||||.|||:|
  Rat  1046 RSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNTFHYA 1110

  Fly  1049 GVASMNITQGVPRIVEIINATKTISTPIITAEL--ENCHSMEFARQVKARIEKTTLAELSSYVEV 1111
            ||::.|:|.||||:.|:||.:|...||.:|..|  ::....|.|:.:..|:|.|||.::::...:
  Rat  1111 GVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAI 1175

  Fly  1112 VC--GPYSCYLA-----IGV-------DMARIKLLGLHIDLDTIVFSILKSRMRVKPTQVEVVAS 1162
            ..  .|.|..:|     :.|       |:|||....|.::||       :..|..:...:|.:|.
  Rat  1176 YYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELD-------RKHMTDRKLTMEQIAE 1233

  Fly  1163 Q------------------SRIVVRVEATRTSTINAELARLA----------------------- 1186
            :                  .::|:|:.     .:|::..::.
  Rat  1234 KINAGFGDDLNCIFNDDNAEKLVLRIR-----IMNSDENKMQEEEEVVDKMDDDVFLRCIESNML 1293

  Fly  1187 --LSLQNV-----VVAGLPNIN--RAVIAVDDARQPPTYKLCIE--GYGLRDVIATYGVVGKRTR 1240
              ::||.:     |...||..:  :.:|..:|.......:..:|  |..|..|::...|...||.
  Rat  1294 TDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTT 1358

  Fly  1241 SNNICEIYQTLGIEAARTIIMSEITEVMEGHGMSVDWRHIMLLASQMTARGEVLGITRHGLAKMR 1305
            ||:|.||:..|||||.|..:..|:..|:...|..|::||:.||...||.||.::.|||||:.:..
  Rat  1359 SNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQD 1423

  Fly  1306 ESVFNLASFEKTADHLFDAAYYGQTDAINGVSERIILGMPACIGTGIFKLLQQHE 1360
            .......|||:|.|.|.:||.:|::|.:.||||.|:||..|..|||.|.||...|
  Rat  1424 TGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAE 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIIIC160	NP_001096987.2	PRK08566	13..919	CDD:236292	354/966 (37%)
		RNAP_III_RPC1_N	24..889	CDD:259847	334/921 (36%)
		RNA_pol_Rpb1_5	839..1304	CDD:282807	183/609 (30%)
		RNAP_III_Rpc1_C	1013..1353	CDD:132723	126/407 (31%)
Polr2a	XP_343923.3	RNAP_II_RPB1_N	19..876	CDD:259848	335/925 (36%)
		RNA_pol_Rpb1_6	896..1079	CDD:398590	33/188 (18%)
		RNAP_II_Rpb1_C	1058..1476	CDD:132720	131/429 (31%)
		CTD	1491..1610	CDD:215026
		Herpes_BLLF1	<1854..>1959	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D591636at2759
OrthoFinder	1	1.000	-	-		FOG0000819
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100210
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720