DRSC/TRiP Functional Genomics Resources

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Protein Alignment RpIIIC160 and POLR1A

DIOPT Version :9

Sequence 1:NP_001096987.2 Gene:RpIIIC160 / 32524 FlyBaseID:FBgn0030687 Length:1383 Species:Drosophila melanogaster
Sequence 2:NP_056240.2 Gene:POLR1A / 25885 HGNCID:17264 Length:1720 Species:Homo sapiens


Alignment Length:1785 Identity:447/1785 - (25%)
Similarity:712/1785 - (39%) Gaps:517/1785 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 KKISHVQFGISGADEIQQEALVRIISKNLYQAQRQPVPYGVLDRRMGISTKDAMCETCGQGLNEC 77
            :::..:.||:..|:|:::.::..|.:.....:...|...|:.|..:|.:....:|.||.|..:.|
Human    10 RRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPADSKEVCSTCVQDFSNC 74

  Fly    78 IGHFGYLDLALPVFHIGHFRSTINILQMICKVCAHVMLKP------------------------- 117
            .||.|:::|.|.|::...|.....:|:..|..| |::..|                         
Human    75 SGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNC-HMLTCPRAVIHLLLCQLRVLEVGALQAVYEL 138

  Fly   118 --------------------EDRQLYEKKLHNPNFSYLGKKALHVQMLAKAK------------K 150
                                |:.:.|..::...|.  ||.:..||:.:.::|            .
Human   139 ERILNRFLEENPDPSASEIREELEQYTTEIVQNNL--LGSQGAHVKNVCESKSKLIALFWKAHMN 201

  Fly   151 VTKCPHCGSPNGGVKKGPGLLKILHDPYKGRKMDSLFTSNMNEMLRSTQTNRDLNSTLGNYSTAE 215
            ..:||||       |.|..:::..|        :|..|.....|:..|...:| :..||    .|
Human   202 AKRCPHC-------KTGRSVVRKEH--------NSKLTITFPAMVHRTAGQKD-SEPLG----IE 246

  Fly   216 E--------LTPLMVLDLFEQIPQRDVALL----------GMCSHDAHPKHLIVTRVFVPPACIR 262
            |        |||....:....:.:.:...|          ||.|. .:|....:..:.|||:..|
Human   247 EAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESR-FNPSVFFLDFLVVPPSRYR 310

  Fly   263 P--------------------------------------SVLSEVKAGTTEDDLTMKQSEILLIN 289
            |                                      .:..||...||:::    :..::.|:
Human   311 PVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTTDEE----KDSLIAID 371

  Fly   290 DVIQRHMATGGKIELIHEDWDFLQLHVALYFHSEISGIPINMAPKKTTRGIVQRLKGKQGRFRCN 354
            ......:.....|:.::..|..||.||.:.|.||:..:.::..|     ||.|.|:.|:|.||.:
Human   372 RSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYP-----GIRQILEKKEGLFRKH 431

  Fly   355 LSGKRVDFSGRTVISPDPNLMINQVGVPVRVAKILTYPERVNPANIRHMRELVRNGPSMHPGANY 419
            :.|||||::.|:||.||..:..|::|:|:..|..||||:.|.|.|::.:|:.|.|||::||||:.
Human   432 MMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQELRQAVINGPNVHPGASM 496

  Fly   420 VQQRGSSFKKYLAYG--NREKVAQEL----------KCGDVVERHLRDGDIVLFNRQPSLHKMSI 472
            |.....|.....|..  .||.||::|          :...:|.||:::|||:|.||||:||:.||
Human   497 VINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCRHVKNGDILLLNRQPTLHRPSI 561

  Fly   473 MCHRAKVQP-QRTFRFNECACTPYNADFDGDEMNLHLPQTEEARAEALILMGNQSNLVTPKNGEI 536
            ..|||::.| ::..|.:...|..|||||||||||.|.||:|..||||.:|.......:.||:|:.
Human   562 QAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQP 626

  Fly   537 LIAATQDFITGGYLLTQKEVFLTKEEAMQLAACFLANEDSTMHIKLPPPALLKPRRLWTGKQMFS 601
            |....||.:..|..:|.:..|.|:|..|:|.  :....|....:||..|::|||..||||||:.|
Human   627 LAGLIQDHMVSGASMTTRGCFFTREHYMELV--YRGLTDKVGRVKLLSPSILKPFPLWTGKQVVS 689

  Fly   602 -LLMRPNDDSQVRLNMVNK----GRNYTR---------NKD-LCSNDSWIHIRNSELMCGVMDKA 651
             ||:....:..:.||:..|    |:.:.:         |.| :|  :|.:.||..||:|||:|||
Human   690 TLLINIIPEDHIPLNLSGKAKITGKAWVKETPRSVPGFNPDSMC--ESQVIIREGELLCGVLDKA 752

  Fly   652 TMGS---GTKQCIFYLLLRDFGESHATKAMWRLARIASYFLQ-NRGFSFGISDVTPSKKLLQHKE 712
            ..||   |...|.:.:    :|...:.|.:..|||:.:.:|| .|||:.|:.|:....|      
Human   753 HYGSSAYGLVHCCYEI----YGGETSGKVLTCLARLFTAYLQLYRGFTLGVEDILVKPK------ 807

  Fly   713 LLLNNGYAKCNEYIELLKAGTLQCQPGCTPEETLESVMLRELSAIRE------------------ 759
                         .::.:...::....|.|:....::.|.|.::..|                  
Human   808 -------------ADVKRQRIIEESTHCGPQAVRAALNLPEAASYDEVRGKWQDAHLGKDQRDFN 859

  Fly   760 ---------------QAAKTCFA-ELH---PTNSALIMALSGSKGSNINISQMIACVGQQAISGK 805
                           :..|.|.. .||   |.||..:|..||:|||.:|..|:...:||..:.|:
Human   860 MIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQSGAKGSTVNTMQISCLLGQIELEGR 924

  Fly   806 RVPNGFENRALPHFERHSAIPAARGFVQNSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYLQ 870
            |.|.....::||.||.:...|.|.|||...|.:|:.|.|||||.||||||||||||||:.:||||
Human   925 RPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIKPPEFFFHCMAGREGLVDTAVKTSRSGYLQ 989

  Fly   871 RRLVKCLEDLVVHYDGTVRNAVNEMVDTIYGGDGLD-------------------PVSME----- 911
            |.::|.||.|||.||.|||::...:|..:||.||||                   .|.|:     
Human   990 RCIIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPKQFPFLASNYEVIMKSQHLH 1054

  Fly   912 ---TRNKPVDLVHQYDNLR---AQHPQGKDRP----LNAEEMSEALETLL--------RTP---- 954
               :|..|...:|.:..::   ::||....|.    ..::::.||::.|.        |:|    
Human  1055 EVLSRADPKKALHHFRAIKKWQSKHPNTLLRRGAFLSYSQKIQEAVKALKLESENRNGRSPGTQE 1119

  Fly   955 -----------------------------------EFAEARDDFKLDVRNHINTVSKRIGQLQKR 984
                                               .||...:.|:..|.::   ..:...|.:|.
Human  1120 MLRMWYELDEESRRKYQKKAAACPDPSLSVWRPDIYFASVSETFETKVDDY---SQEWAAQTEKS 1181

  Fly   985 YEKCIDLCHQIECLTTEQLLQFVRRINDRYNRAVTEPGTAVGAIAAQSIGEPGTQMTLKTFHFAG 1049
            |||     .::.......|||.      ::.|::.|||.|||.:||||||||.|||||.||||||
Human  1182 YEK-----SELSLDRLRTLLQL------KWQRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAG 1235

  Fly  1050 VASMNITQGVPRIVEIIN-ATKTISTPIITAELENC-HSMEFARQVKARIEKTTLAELSSYVEV- 1111
            ...||:|.|:||:.||:. |:..|.||:::..:.|. .:::..:.:|.::.:..|.|:...::| 
Human  1236 RGEMNVTLGIPRLREILMVASANIKTPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQ 1300

  Fly  1112 --VCG-----------------PYSCY----------LAIGVDMARIKLL--------------- 1132
              .|.                 |::.|          :...::....|||               
Human  1301 ESFCMEEKQNKFQVYQLRFQFLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFR 1365

  Fly  1133 ----------------------------------------------------------------- 1132
                                                                             
Human  1366 NVNTRRATQRDLDNAGELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESE 1430

  Fly  1133 ------------------------------------GLHIDLDTIVFSILKSRMRVKPTQVEVVA 1161
                                                ||..:.|..:.::|....  |||..:...
Human  1431 EEEEREGEENDDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPR--KPTHSQEPQ 1493

  Fly  1162 SQSRIVVRVEATR--------------------------TSTINAELARLALSL-QNVVVAGLPN 1199
            ....:..||:|.|                          ...||.:::.|.:|| ...|:.....
Human  1494 GPEAMERRVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKG 1558

  Fly  1200 INRAVI-AVDDARQPPTYKLCIEGYGLRDVIATYGVVG-KRTRSNNICEIYQTLGIEAARTIIMS 1262
            |.|.:: ...:.:......|..||..|.::.....|:. :|..||:|..|..|.|||||..:|..
Human  1559 ITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEK 1623

  Fly  1263 EITEVMEGHGMSVDWRHIMLLASQMTARGEVLGITRHGLAKMRESVFNLASFEKTADHLFDAAYY 1327
            ||.:|...:|::||.||:.|:|..|...|....:.|.|: :...|.....:||.:...|..|...
Human  1624 EIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGI-RSNSSPLQQMTFETSFQFLKQATML 1687

  Fly  1328 GQTDAINGVSERIILGMPACIGTGIFKLLQ 1357
            |..|.:...|..:::|.....|||:|:|.|
Human  1688 GSHDELRSPSACLVVGKVVRGGTGLFELKQ 1717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RpIIIC160NP_001096987.2 PRK08566 13..919 CDD:236292 312/1114 (28%)
RNAP_III_RPC1_N 24..889 CDD:259847 297/1046 (28%)
RNA_pol_Rpb1_5 839..1304 CDD:282807 168/722 (23%)
RNAP_III_Rpc1_C 1013..1353 CDD:132723 111/516 (22%)
POLR1ANP_056240.2 PRK08566 4..1025 CDD:236292 306/1074 (28%)
RNAP_I_RPA1_N 16..1004 CDD:259844 296/1047 (28%)
RNA_pol_Rpb1_5 958..1671 CDD:282807 169/729 (23%)
Bridging helix. /evidence=ECO:0000250 961..973 9/11 (82%)
RNAP_I_Rpa1_C 1199..1716 CDD:132722 112/519 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1365..1498 7/134 (5%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0086
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D591636at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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