DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIIIC160 and ama-1

DIOPT Version :9

Sequence 1:	NP_001096987.2	Gene:	RpIIIC160 / 32524	FlyBaseID:	FBgn0030687	Length:	1383	Species:	Drosophila melanogaster
Sequence 2:	NP_500523.4	Gene:	ama-1 / 177190	WormBaseID:	WBGene00000123	Length:	1856	Species:	Caenorhabditis elegans

Alignment Length:	1523	Identity:	515/1523 - (33%)
Similarity:	765/1523 - (50%)	Gaps:	252/1523 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ISHVQFGISGADEIQQEALVRIISKNLYQAQRQPVPYGVLDRRMGISTKDAMCETCGQGLNECIG 79
            :|.|||||.|.:||::.::..:....:|: ..:|...|::|.|.|:..:...|.||...|.:|.|
Worm    15 VSRVQFGILGPEEIKRMSVAHVEFPEVYE-NGKPKLGGLMDPRQGVIDRRGRCMTCAGNLTDCPG 78

  Fly    80 HFGYLDLALPVFHIGHFRSTINILQMICKVCAHVML-KPEDRQLYEKKLHNPNFSYLGKKALHVQ 143
            |||:|:||.||||||....|:.||:.:|..|..::: |...|.|...|....|..   |:...:.
Worm    79 HFGHLELAKPVFHIGFLTKTLKILRCVCFYCGRLLIDKSAPRVLEILKKTGTNSK---KRLTMIY 140

  Fly   144 MLAKAKKVTKCPHCGSPNGGVKKGPGLLKILHDPYK-GRK------------------MDSLFTS 189
            .|.|||.|.:        |..:|..|:.....||.. |:|                  :::.:..
Worm   141 DLCKAKSVCE--------GAAEKEEGMPDDPDDPMNDGKKVAGGCGRYQPSYRRVGIDINAEWKK 197

  Fly   190 NMNEMLRSTQTNRDLNSTLGNYSTAEELTPLMVLDLFEQIPQRDVALLGMCSHDAHPKHLIVTRV 254
            |:||   .||..:.:            ||...||::|:||...|:.::||....|.|:.:|.|.:
Worm   198 NVNE---DTQERKIM------------LTAERVLEVFQQITDEDILVIGMDPQFARPEWMICTVL 247

  Fly   255 FVPPACIRPSVLSEVKAGTTEDDLTMKQSEILLINDVIQRHMATGGKIELIHEDWDFLQLHVALY 319
            .|||..:||:|:: ..:...:||||.|.|:|:..|..:||:.|.|....::.:|...||.|||..
Worm   248 PVPPLAVRPAVVT-FGSAKNQDDLTHKLSDIIKTNQQLQRNEANGAAAHVLTDDVRLLQFHVATL 311

  Fly   320 FHSEISGIPINMAPKKTTR---GIVQRLKGKQGRFRCNLSGKRVDFSGRTVISPDPNLMINQVGV 381
            ..:.|.|:|  .|.:|..|   .|.||||||:||.|.||.|||||||.||||:.||||.|:.|||
Worm   312 VDNCIPGLP--TATQKGGRPLKSIKQRLKGKEGRIRGNLMGKRVDFSARTVITADPNLPIDTVGV 374

  Fly   382 PVRVAKILTYPERVNPANIRHMRELVRNGPSMHPGANY-VQQRGSSFKKYLAYGNREKVAQELKC 445
            |..:|:.||:||.|.|.|:..::|||..|.:.:|||.| :::.|:  :..|.|..| .....|:.
Worm   375 PRTIAQNLTFPEIVTPFNVDKLQELVNRGDTQYPGAKYIIRENGA--RVDLRYHPR-AADLHLQP 436

  Fly   446 GDVVERHLRDGDIVLFNRQPSLHKMSIMCHRAKVQPQRTFRFNECACTPYNADFDGDEMNLHLPQ 510
            |..||||::||||::|||||:|||||:|.||.|:.|..|||.|....:|||||||||||||||||
Worm   437 GYRVERHMKDGDIIVFNRQPTLHKMSMMGHRVKILPWSTFRMNLSVTSPYNADFDGDEMNLHLPQ 501

  Fly   511 TEEARAEALILMGNQSNLVTPKNGEILIAATQDFITGGYLLTQKEVFLTKEEAMQLAACFLANED 575
            :.|.|||...:......|:||:..:.::...||.:....::|:::||:.....|.| ..:|...|
Worm   502 SLETRAEIEEIAMVPRQLITPQANKPVMGIVQDTLCAVRMMTKRDVFIDWPFMMDL-LMYLPTWD 565

  Fly   576 STMHIKLPPPALLKPRRLWTGKQMFSLLMRPNDDSQVRLNMVNKGRNYTRNKDLCSNDS----WI 636
            .    |:|.||:|||:.||||||:|||::..|         ||..|.::.:.|  |.||    ||
Worm   566 G----KVPQPAILKPKPLWTGKQVFSLIIPGN---------VNVLRTHSTHPD--SEDSGPYKWI 615

  Fly   637 H-------IRNSELMCGVMDKATMGSGTKQCIFYLLLRDFGESHATKAMWRLARIASYFLQNRGF 694
            .       |.:.||:.|::...|:|..... :.:::..:.|...|......:..:.:.:|...|.
Worm   616 SPGDTKVIIEHGELLSGIVCSKTVGKSAGN-LLHVVTLELGYEIAANFYSHIQTVINAWLIREGH 679

  Fly   695 SFGISDVTPSKKLLQHKELLLNNGYAKCN----EYIELLKAGTLQCQPGCTPEETLESVMLRELS 755
            :.||.|....    |...|.:.|...|..    :.||......|:..||.|..:|.|:.:.:.|:
Worm   680 TIGIGDTIAD----QATYLDIQNTIRKAKQDVVDVIEKAHNDDLEPTPGNTLRQTFENKVNQILN 740

  Fly   756 AIREQAAKTCFAELHPTNSALIMALSGSKGSNINISQMIACVGQQAISGKRVPNGFENRALPHFE 820
            ..|::...:....|...|:...|.:||||||.|||||:|||||||.:.|||:|.||.:|.||||.
Worm   741 DARDRTGSSAQKSLSEFNNFKSMVVSGSKGSKINISQVIACVGQQNVEGKRIPFGFRHRTLPHFI 805

  Fly   821 RHSAIPAARGFVQNSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYLQRRLVKCLEDLVVHYD 885
            :....|.::|||:||:.:||||:|||||.|.|||||:|||||||||||:||||:|.:|.::|:||
Worm   806 KDDYGPESKGFVENSYLAGLTPSEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVNYD 870

  Fly   886 GTVRNAVNEMVDTIYGGDGLDPVSMETRNKP--------------VDLVHQYDNLRAQHPQGKDR 936
            |||||::.:||...||.||||.:.:|.:|.|              :||.   ||...:....:|.
Worm   871 GTVRNSLAQMVQLRYGEDGLDGMWVENQNMPTMKPNNAVFERDFRMDLT---DNKFLRKNYSEDV 932

  Fly   937 PLNAEEMSEALETLLRTPEFAEARDD-------------------------------FKLDVRNH 970
            ....:|..:.:.  |...|:::..:|                               ||:|:|..
Worm   933 VREIQESEDGIS--LVESEWSQLEEDRRLLRKIFPRGDAKIVLPCNLQRLIWNAQKIFKVDLRKP 995

  Fly   971 INT----VSKRIGQLQKR---------------YEKCI--------DLCHQIEC----LTTEQLL 1004
            :|.    |...:.:|.|:               |...:        .||.:..|    |.:|...
Worm   996 VNLSPLHVISGVRELSKKLIIVSGNDEISKQAQYNATLLMNILLRSTLCTKNMCTKSKLNSEAFD 1060

  Fly  1005 QFVRRINDRYNRAVTEPGTAVGAIAAQSIGEPGTQMTLKTFHFAGVASMNITQGVPRIVEIINAT 1069
            ..:..|..|:.:|:.:||..|||:||||:|||.|||||.|||:|||::.|:|.||||:.||||.:
Worm  1061 WLLGEIESRFQQAIAQPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKEIINVS 1125

  Fly  1070 KTISTPIITAELENCHSM--EFARQVKARIEKTTLAELSSYVEVVCGPYSCYLAIGV-------- 1124
            ||:.||.:|..|....:.  |.|:.|..::|.|||.:::....:...|......|..
Worm  1126 KTLKTPSLTVFLTGAAAKDPEKAKDVLCKLEHTTLKKVTCNTAIYYDPDPKNTVIAEDEEWVSIF 1190

  Fly  1125 ------DMARIKLLGLHIDLDTIVFSILKSRMRVKPTQVEVVASQ------------------SR 1165
                  |::|.....|.|:||       :.||..|...:|::|.:                  .:
Worm  1191 YEMPDHDLSRTSPWLLRIELD-------RKRMVDKKLTMEMIADRIHGGFGNDVHTIYTDDNAEK 1248

  Fly  1166 IVVRVEATRTSTINAELARL-------------ALSLQNVVVAGLPNINRAVIAVDDARQPPT-- 1215
            :|.|:.........|:..::             |..|.::.:.|:|.|::..:     .||.|
Worm  1249 LVFRLRIAGEDKGEAQEEQVDKMEDDVFLRCIEANMLSDLTLQGIPAISKVYM-----NQPNTDD 1308

  Fly  1216 -----------------YKLCIEGYGLRDVIATYGVVGKRTRSNNICEIYQTLGIEAARTIIMSE 1263
                             :.|..:|..|..|::...:...||.||:||||::.|||||.|..|..|
Worm  1309 KKRIIITPEGGFKSVADWILETDGTALLRVLSERQIDPVRTTSNDICEIFEVLGIEAVRKAIERE 1373

  Fly  1264 ITEVMEGHGMSVDWRHIMLLASQMTARGEVLGITRHGLAKMRESVFNLASFEKTADHLFDAAYYG 1328
            :..|:...|..|::||:.||...|||:|.::.|||||:.:.........|||:|.|.|.:||.:.
Worm  1374 MDNVISFDGSYVNYRHLALLCDVMTAKGHLMAITRHGINRQEVGALMRCSFEETVDILMEAAVHA 1438

  Fly  1329 QTDAINGVSERIILGMPACIGTGIFKLL 1356
            :.|.:.||||.|:||..|..|||.|.|:
Worm  1439 EEDPVKGVSENIMLGQLARCGTGCFDLV 1466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIIIC160	NP_001096987.2	PRK08566	13..919	CDD:236292	361/956 (38%)
		RNAP_III_RPC1_N	24..889	CDD:259847	341/903 (38%)
		RNA_pol_Rpb1_5	839..1304	CDD:282807	183/606 (30%)
		RNAP_III_Rpc1_C	1013..1353	CDD:132723	128/405 (32%)
ama-1	NP_500523.4	PRK08566	7..893	CDD:236292	358/931 (38%)
		RNAP_II_RPB1_N	17..870	CDD:259848	342/906 (38%)
		RNA_pol_Rpb1_5	824..1420	CDD:282807	183/612 (30%)
		RNA_pol_Rpb1_6	890..1073	CDD:282801	30/187 (16%)
		RNAP_II_Rpb1_C	1053..1468	CDD:132720	133/426 (31%)
		CTD	1493..1584	CDD:215026
		CytochromB561_N	<1735..>1828	CDD:286826
		DUF3432	1746..1837	CDD:288743
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D591636at2759
OrthoFinder	1	1.000	-	-		FOG0000819
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100210
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720