Protein Alignment Graf and Ophn1

DIOPT Version :10

• Sequence 1: NP_996441.2
• Gene: Graf / 32522
• FlyBaseID: FBgn0030685
• Length: 1025
• Species: Drosophila melanogaster
• Sequence 2: NP_443208.1
• Gene: Ophn1 / 94190
• MGIID: 2151070
• Length: 802
• Species: Mus musculus
• Alignment Length: 916
• Identity: 305/916 - (33%)
• Similarity: 448/916 - (48%)
• Gaps: 142/916 - (15%)

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            |..||||.:|.:||||||:.|..:|:||:.|:..||.:||:...|:||.:..|:.:::.:..|..
Mouse     2 GHPPLEFSDCYLDSPDFRQRLKYYEEELERTNKFIKDVIKDGSALISAMRNYSSAVQKFSQTLQS 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.|:.||...||||..|.||.|.|..::..:|:||..|:..|...:|:.||.|||:|||..||.|
Mouse    67 FQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVQNASDLLIKPLETFRKEQIGFTKERK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            |||:|..|:|....:|.|::|:||.|:.:.|||..:......:.:.||.||.:||||||..||..
Mouse   132 KKFEKDGERFYSLLDRHLHLSSKKKESQLLEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNI 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYME--KRTK 267
            ||.:|||:....:......|..:|...|.|.|:..:|.||.:|...||::.|||.:..|  :..|
Mouse   197 VEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCK 261

  Fly   268 PEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARD 332
            .....|..|||:..||.: |.||        |.||||.::|:.|..||:...|      :|.|:.
Mouse   262 LPGQPTIEGYLYTQEKWA-LGIS--------WAKYYCRYEKETRMLTMIPMEQ------KPGAKQ 311

  Fly   333 DE-KLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGK 395
            .. .|||..|.||.:| .:||||||:...|:||.: |.||.||.:.|.|:.||||.||.|..|
Mouse   312 GPVDLTLKYCVRRKTESIDKRFCFDIETNERPGTI-TLQAPSEANRRLWMEAMDGKEPIYHTP-- 373

  Fly   396 IKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDK 460
            |...|...|:|.||.|:|:||..:|.:|::.||:||..|...::.|||....:.|...||   |.
Mouse   374 ITKQEEMELNEVGFKFVRKCINFIETKGIKTEGLYRTVGSNIQVQKLLYAFFDPKCPGDV---DF 435

  Fly   461 YRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQML 525
            :....:..||.|:||.|||||:||:|||:.|.:.:.|||.:.|:.|:..:|.||||||:.|.:||
Mouse   436 HNSDWDIKTITSSLKFYLRNLSEPVMTYKLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREML 500

  Fly   526 DMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFK 590
            :::|.||.:|....::|.|:..|:||:|||||:|.:|::|||:::|||.|||:.|||:::.:|:.
Mouse   501 ELLIKHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYL 565

  Fly   591 NKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKI-Y 654
            ..|. |.::|..             ||.|:.....                  .|:.::::.: .
Mouse   566 GPPE-DSQVPPV-------------PPPRVTARRH------------------KPITISKRLLRE 598

  Fly   655 RVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSINNL 719
            :.|..|:..:.....|....|||   .:.||            |.|| .:|..:..|...|
Mouse   599 KTVFYTSSLDENKDESHHQTPNG---TITSN------------LDPP-KLLQHLKPPMQKS---- 643

  Fly   720 HTISKNET-----STRRYVPDTEIAP----DYG--IIGANNGGVTLQSHHAVPVSSTSNFRHPEY 773
                 .||     |..|.|.|.:..|    |.|  :....:||.     .|.|.:|.
Mouse   644 -----GETDPGRKSPSRPVSDCQSEPCLETDVGRLLFRLQDGGT-----KATPKASN-------- 690

  Fly   774 LMTTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASG-PQQHPPVQR 837
                 .||..||     :|.|||        ..:...:|...|..||   |...| .:..||.::
Mouse   691 -----GPVPGSG-----HTKTSS--------FHIRRPAPRPMAHHKE---GDTDGFSKVRPPGEK 734

  Fly   838 GLHSYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALI 902
                  ||....|:.|.      |..|.|::.... .......|||:..:...:.|..|..:...
Mouse   735 ------QTIIRPPVRPP------DPPCRSITPQKP-EPKPETGSGNADEIPSSVVASRTRFFETA 786

  Fly   903 SSQNSS 908
            |.:..|
Mouse   787 SRKTGS 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_996441.2	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	79/205 (39%)
		BAR-PH_GRAF_family	273..390	CDD:269953	50/118 (42%)
		RhoGAP	383..584	CDD:470621	90/200 (45%)
		SH3_GRAF-like	967..1020	CDD:212815
Ophn1	NP_443208.1	BAR_OPHN1	19..225	CDD:153317	79/205 (39%)
		BAR-PH_GRAF_family	267..370	CDD:269953	50/118 (42%)
		RhoGAP_Graf	363..559	CDD:239839	90/200 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	606..665		18/83 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	681..802		34/159 (21%)