DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and Ophn1

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001300683.1	Gene:	Ophn1 / 94190	MGIID:	2151070	Length:	802	Species:	Mus musculus

Alignment Length:	916	Identity:	305/916 - (33%)
Similarity:	448/916 - (48%)	Gaps:	142/916 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            |..||||.:|.:||||||:.|..:|:||:.|:..||.:||:...|:||.:..|:.:::.:..|..
Mouse     2 GHPPLEFSDCYLDSPDFRQRLKYYEEELERTNKFIKDVIKDGSALISAMRNYSSAVQKFSQTLQS 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.|:.||...||||..|.||.|.|..::..:|:||..|:..|...:|:.||.|||:|||..||.|
Mouse    67 FQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVQNASDLLIKPLETFRKEQIGFTKERK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            |||:|..|:|....:|.|::|:||.|:.:.|||..:......:.:.||.||.:||||||..||..
Mouse   132 KKFEKDGERFYSLLDRHLHLSSKKKESQLLEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNI 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYME--KRTK 267
            ||.:|||:....:......|..:|...|.|.|:..:|.||.:|...||::.|||.:..|  :..|
Mouse   197 VEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCK 261

  Fly   268 PEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARD 332
            .....|..|||:..||.: |.||        |.||||.::|:.|..||:...|      :|.|:.
Mouse   262 LPGQPTIEGYLYTQEKWA-LGIS--------WAKYYCRYEKETRMLTMIPMEQ------KPGAKQ 311

  Fly   333 DE-KLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGK 395
            .. .|||..|.||.:| .:||||||:...|:||.: |.||.||.:.|.|:.||||.||.|..|
Mouse   312 GPVDLTLKYCVRRKTESIDKRFCFDIETNERPGTI-TLQAPSEANRRLWMEAMDGKEPIYHTP-- 373

  Fly   396 IKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDK 460
            |...|...|:|.||.|:|:||..:|.:|::.||:||..|...::.|||....:.|...||   |.
Mouse   374 ITKQEEMELNEVGFKFVRKCINFIETKGIKTEGLYRTVGSNIQVQKLLYAFFDPKCPGDV---DF 435

  Fly   461 YRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQML 525
            :....:..||.|:||.|||||:||:|||:.|.:.:.|||.:.|:.|:..:|.||||||:.|.:||
Mouse   436 HNSDWDIKTITSSLKFYLRNLSEPVMTYKLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREML 500

  Fly   526 DMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFK 590
            :::|.||.:|....::|.|:..|:||:|||||:|.:|::|||:::|||.|||:.|||:::.:|:.
Mouse   501 ELLIKHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYL 565

  Fly   591 NKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKI-Y 654
            ..|. |.::|..             ||.|:.....                  .|:.::::.: .
Mouse   566 GPPE-DSQVPPV-------------PPPRVTARRH------------------KPITISKRLLRE 598

  Fly   655 RVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSINNL 719
            :.|..|:..:.....|....|||   .:.||            |.|| .:|..:..|...|
Mouse   599 KTVFYTSSLDENKDESHHQTPNG---TITSN------------LDPP-KLLQHLKPPMQKS---- 643

  Fly   720 HTISKNET-----STRRYVPDTEIAP----DYG--IIGANNGGVTLQSHHAVPVSSTSNFRHPEY 773
                 .||     |..|.|.|.:..|    |.|  :....:||.     .|.|.:|.
Mouse   644 -----GETDPGRKSPSRPVSDCQSEPCLETDVGRLLFRLQDGGT-----KATPKASN-------- 690

  Fly   774 LMTTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASG-PQQHPPVQR 837
                 .||..||     :|.|||        ..:...:|...|..||   |...| .:..||.::
Mouse   691 -----GPVPGSG-----HTKTSS--------FHIRRPAPRPMAHHKE---GDTDGFSKVRPPGEK 734

  Fly   838 GLHSYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALI 902
                  ||....|:.|.      |..|.|::.... .......|||:..:...:.|..|..:...
Mouse   735 ------QTIIRPPVRPP------DPPCRSITPQKP-EPKPETGSGNADEIPSSVVASRTRFFETA 786

  Fly   903 SSQNSS 908
            |.:..|
Mouse   787 SRKTGS 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	79/205 (39%)
		BAR-PH_GRAF_family	273..390	CDD:269953	50/118 (42%)
		PH	279..383	CDD:278594	40/105 (38%)
		RhoGAP	383..584	CDD:295372	90/200 (45%)
		SH3_GRAF-like	967..1020	CDD:212815
Ophn1	NP_001300683.1	BAR_OPHN1	19..225	CDD:153317	79/205 (39%)
		PH	266..363	CDD:278594	44/112 (39%)
		BAR-PH_GRAF_family	267..370	CDD:269953	50/118 (42%)
		RhoGAP_Graf	363..559	CDD:239839	90/200 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..665		18/83 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	681..802		34/159 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836297
Domainoid	1	1.000	238	1.000	Domainoid score	I2290
eggNOG	1	0.900	-	-		E1_KOG1451
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45894
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101903
Panther	1	1.100	-	-	O	PTHR12552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.720