DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and ARHGAP29

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001315593.1	Gene:	ARHGAP29 / 9411	HGNCID:	30207	Length:	1261	Species:	Homo sapiens

Alignment Length:	1093	Identity:	217/1093 - (19%)
Similarity:	362/1093 - (33%)	Gaps:	347/1093 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PLEFEECIVDSPD-------FRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAI 70
            |||.:..::.:.|       :.:..:::.|.:  .|...|::..|::...:..|:.......:.|
Human   191 PLELDNVLLKNTDSIELALSYAKTWSKYTKNI--VSWVEKKLNLELESTRNMVKLAEATRTNIGI 253

  Fly    71 -------------LLNDFNF-----ECIGTAQTD--------------------------DENVI 91
                         ||||...     :.|...|.:                          ::|.:
Human   254 QEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKM 318

  Fly    92 CE---SLKRFGAIIGNIEDEREK----MLTLADKHIIESLEDFRKKQIGGVKEN-KKKFDKK--- 145
            .|   :||:...:....:||.||    |....::|:..|         ||:.:| .|:.:||
Human   319 LEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSS---------GGLAKNLNKQLEKKRRL 374

  Fly   146 TEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEFVEILLA 210
            .|:..|..|. .|...|.....::|....|...:||.:.:     ||....|..:..:.|.:.|
Human   375 EEEALQKVEE-ANELYKVCVTNVEERRNDLENTKREILAQ-----LRTLVFQCDLTLKAVTVNL- 432

  Fly   211 FISGWLVFYHTAHEQAEDHRDYLQDL-------------RHKVQKTRENFEE------------- 249
                    :|..|.||....|.||.|             ...|:.|....||
Human   433 --------FHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDGNVNKHLNSS 489

  Fly   250 ---------AREKVTEL---KTKYMEKR-------TKPEEIFTKRGYLFLM----------EKSS 285
                     :.|.|..|   ..|..|.|       |.|..|   |.:.|.|          .:|.
Human   490 QPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFI---RSWTFGMFSDSESTGGSSESR 551

  Fly   286 ILKISLLEPF-----------------------------KATWTKYYCTFKKQKREFTMLQFNQM 321
            .|....:.|.                             ..|......||||     |::....:
Human   552 SLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGTFKK-----TLMSKAAL 611

  Fly   322 NHNFTR----PEARDDEKLTLFS----------CQRRASEFEKRFCFDLTFKEKPGVVYTFQALS 372
            .|.|.:    .:.||.|.:.:|.          |.|:..|.....|   ..::.||.::.|
Human   612 THKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIIC---GHQKLPGKIHLF---- 669

  Fly   373 EKDHRYWISAMDGTEPTYLAPGKIKVSEAYHLDEAGFMFIRR-CIQVLEIRGLEDEGIYRKSGVG 436
                        |.|.|.:|          ..:..|..||.: |...:|.|.|..:||||..|..
Human   670 ------------GAEFTQVA----------KKEPDGIPFILKICASEIENRALCLQGIYRVCGNK 712

  Fly   437 TKISKL---LALGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAA 498
            .|..||   |..|::..:..:          ..|:.|...||:|||.|.||.:.::.:.:||:.|
Human   713 IKTEKLCQALENGMHLVDISE----------FSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLA 767

  Fly   499 K--------QETLNQRVN---------EVHKLVYK-------LPQPNFQMLDMVICHLTDVSRKY 539
            |        |||....:.         |:::::.|       ||..||..|..:|.||..|....
Human   768 KEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHA 832

  Fly   540 EKNKMSVFNLGVVFGPTLLRPREE----SVAAILDIKFNNIVINILIDNYERIFKNKPSADIKLP 600
            |:|||:..||||:|||:|:|||..    :::::.:......::..||...::||    ...::..
Human   833 EENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIF----DGSLQPQ 893

  Fly   601 DATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKIYRVVSKTNCTEP 665
            |...:..::.......|...|....|.::..            :..|.:::.|:...|::...|
Human   894 DVMCSIGVVDQGCFPKPLLSPEERDIERSMK------------SLFFSSKEDIHTSESESKIFE- 945

  Fly   666 TMSSSLQNIPNGDNYALGSNAMNSSGGAQCI----SLSPPMHMLNGILSPTIGSINNLHTISKNE 726
             .::|.:......| |||......|..||.:    :.|....:.:| .:|...|:.:    .::.
Human   946 -RATSFEESERKQN-ALGKCDACLSDKAQLLLDQEAESASQKIEDG-KTPKPLSLKS----DRST 1003

  Fly   727 TSTRRYVPDTEIAP-----DYGII--------GANNGGVTL-------------QSHHAVPVSST 765
            .:..|:.|.|:|.|     |..::        |.|.|.|.|             :...|..|.|.
Human  1004 NNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSK 1068

  Fly   766 SN---------FRHPEY---------LMTTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSP 812
            .|         .:..:|         .|...:.:.:.|    :.|:...:|.:|.|....|  .|
Human  1069 FNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKG----VTTSLQISGDHSINATQPS--KP 1127

  Fly   813 PNTAMRKERFLGSASGPQQHP--PVQ--RGLHSYGQTKHYSPLMPTSTSSSND 861
            ....:|..|..........:|  ||:  |.|.....|..|.|..|..:...|:
Human  1128 YAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNE 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	48/260 (18%)
		BAR-PH_GRAF_family	273..390	CDD:269953	27/169 (16%)
		PH	279..383	CDD:278594	24/156 (15%)
		RhoGAP	383..584	CDD:295372	66/232 (28%)
		SH3_GRAF-like	967..1020	CDD:212815
ARHGAP29	NP_001315593.1	BAR	220..436	CDD:299863	44/241 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..501		0/19 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	541..600		4/58 (7%)
		C1	612..657	CDD:197519	9/44 (20%)
		RhoGAP_PARG1	669..881	CDD:239874	67/247 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	981..1011		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1153		8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1178..1238		1/3 (33%)
		Interaction with PTPN13/PTPL1. /evidence=ECO:0000269\|PubMed:9305890	1258..1261
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940