DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and AGD4

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001320312.1	Gene:	AGD4 / 837629	AraportID:	AT1G10870	Length:	780	Species:	Arabidopsis thaliana

Alignment Length:	695	Identity:	126/695 - (18%)
Similarity:	247/695 - (35%)	Gaps:	174/695 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLNDFNFECIGTAQTD 86
            |||.|::.:...|...|....:.:::.|.||..|......|......|..|.:|.      ...|
plant     9 DSPMFQKQVCSLEGTADELKDRCQKLYKGVKKFMGTLGEASKGESAFAACLEEFG------GGPD 67

  Fly    87 DENVICESLKRFGAIIG-------NIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENKKKFDK 144
            |.    .||...|.:|.       .:...:|.:.:..:..::|.|.:|....:...||::.:|||
plant    68 DP----ISLSIGGPVISKFINALRELASYKEFLCSQVEHVLLERLMNFISVDLQEAKESRHRFDK 128

  Fly   145 KTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEFVEILL 209
            ....:.||:|:|:::........:.|.:..|...:..:.:...:.|..:..::.:.|:||:|.:.
plant   129 AAHSYDQSREKFVSLKKNTRGEIVAELEEDLENSKSTFEKSRFNLVNSLMTIEAKKKYEFLESIS 193

  Fly   210 AFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRE--NFEEAR--EKVTELKT----------- 259
            |.:...|.::...::.......::..:....|:::|  ..|:.|  .::.|.:|
plant   194 AIMDAHLRYFKLGYDLLNQLEPFIHQILTYAQQSKEQSKIEQDRLARRIQEFRTQSELDSQQLVA 258

  Fly   260 ------------------KYMEKRTKPEEIFTKRGYLFLMEKSSILKISLLEPF---KATWTKYY 303
                              |..|.....::...|:||  |:::||.|:......|   .:..:.||
plant   259 NAESSGANGNRVGGNIPYKNTETSLTADKEVIKQGY--LLKRSSSLRTDWKRKFFVLDSHGSMYY 321

  Fly   304 CTFKKQKREFTMLQFN-QMNHN---FTRPEARD----------------DEKLTLFSCQRRASEF 348
            ......|...:...:: ..:||   |.|..||.                |.:.:|....  |.:.
plant   322 YRTNGNKSMGSHHHYSGSSDHNTGVFGRFRARHNRSGSLTEGSLGYNTIDLRTSLIKLD--AEDM 384

  Fly   349 EKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGKIKVSEAYHLDEAGF---- 409
            :.|.||.:...:|   .||.||.:..|...|::.:.....|.|....::.|...:||:...
plant   385 DLRLCFRIISPQK---TYTLQAENGADRMDWVNKITKAIGTLLNSHFLQQSPVRYLDKDNSSSAP 446

  Fly   410 --------------------------------------------------MFIRRCIQVLEIRGL 424
                                                              :.:..|||.
plant   447 ANAVVSGDQIRHNDSRQNIGDDVSTILRGLPGNNACAECNAPEPDWASLNLGVLLCIQC------ 505

  Fly   425 EDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTY- 488
              .|::|..||  .|||:.:|.|:.|..:...: |.:|:|  .|...::|...|.:|::..:.:
plant   506 --SGVHRNLGV--HISKVRSLSLDVKVWEPTIL-DLFRNL--GNVYCNSLWEGLLHLDDDCVAFC 563

  Fly   489 ------QYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQMLDMVICHLTDVSRKYE----KNK 543
                  ..|:...:...:::.:  |.|.: ::.|..:....:.|....:|:..||.:|    :|.
plant   564 SEDGSALSHASVSKPCPEDSFS--VKEKY-ILGKYLEKALVIKDESEANLSAASRIWEAVQSRNI 625

  Fly   544 MSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERI 588
            ..::.|.|..|.          ..|::.||::|..   ||.|..|
plant   626 REIYRLIVTTGD----------VNIINTKFDDITD---IDAYHHI 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	38/212 (18%)
		BAR-PH_GRAF_family	273..390	CDD:269953	30/139 (22%)
		PH	279..383	CDD:278594	27/126 (21%)
		RhoGAP	383..584	CDD:295372	43/265 (16%)
		SH3_GRAF-like	967..1020	CDD:212815
AGD4	NP_001320312.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910