DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and AGD1

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_201004.2	Gene:	AGD1 / 836319	AraportID:	AT5G61980	Length:	828	Species:	Arabidopsis thaliana

Alignment Length:	775	Identity:	134/775 - (17%)
Similarity:	250/775 - (32%)	Gaps:	268/775 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLN-----DFNF---- 77
            |||.||:.:...|:..:....:..|..|..:.....              |.     |..|
plant     8 DSPMFRQQMQSMEESAELLRLRCLRFYKGCRKYTEG--------------LGEGYDADIGFVNAL 58

  Fly    78 ECIGTAQTDDENVICES-----LKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKE 137
            |..|....|.   :|.:     :.:|...:..|...:|.:.:..:..:.:.|..|....:..|||
plant    59 ESFGGGHNDP---VCVAFGGPVMTKFTIALREIGTYKEVLRSQVEHMLSDRLLQFVNGDVHEVKE 120

  Fly   138 NKKKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKF 202
            .:|:|||.|..:.|::|::|::......:.....:..|......:.|.....|..:...:.:.:|
plant   121 ARKRFDKATITYDQAREKYLSLRKSTRLDVAATIEEDLHSARTTFEQARFHLVSALSNAESKKRF 185

  Fly   203 EFVEILLA---------------------FISGWLVFYHTAHEQA--------EDHRDYLQD--- 235
            ||:|.:..                     ||:..|.:.|.:.|.|        |..::|.:.
plant   186 EFLEAVSGTMDAHLRFFKQGYELLHQMEPFINQVLAYAHQSRECANYEMASLNERMQEYQRQVDR 250

  Fly   236 -------------LRHKVQKTRENFE-----EAREKVTELKTKYMEKRTKPEEIFTKRGYLFLME 282
                         :||..:.:::..|     .|:.||..::..|:.||:.......||.:..|..
plant   251 ETRNSCVSPTGDGMRHNSRNSQKVIEAVMQSAAKGKVQTIRQGYLSKRSSNLRGDWKRRFFILDS 315

  Fly   283 KSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNF------------------TRPE 329
            :      .:|..::..|     .:.......:::..|..:.|.                  .:|.
plant   316 R------GMLYYYRKPW-----NWSSGNGSRSVVHRNMASENSPGLLSRWLSSHYHGGVHDEKPV 369

  Fly   330 ARDDEKLTLFSCQRRASEFEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWI-------------- 380
            ||....|...:.:..|.:.:.||||.:.   .|..|||.||.:.:|...||
plant   370 ARHTVNLLTSTIKVDADQTDLRFCFRII---SPTKVYTLQAENAQDQMDWIEKITGVIASLLSFQ 431

  Fly   381 ---------SAMDGTEPTYLAPGKIKVSEAYHLD--EAGFMFIRR------------CIQ----- 417
                     |.:||.: |:.|.....:::.|.::  |:|...:..            |:|
plant   432 TPERAIMRLSTVDGGD-TFSASDSGSLADPYDIEQAESGESTVEHPMTGGNRSRFSGCLQQHDMV 495

  Fly   418 --------VLEIRG------------------------LEDEGIYRKSGVGTKISKLLALGLNQK 450
                    :..:.|                        :|..||:|..||  .|||:.:|.|:.|
plant   496 KTEKPIDVLTRVLGNERCADCGAPEPDWASLNLGVLICIECSGIHRNLGV--HISKVRSLTLDVK 558

  Fly   451 -----------ESDDVFVDDKYRDLMESNTIASAL-------------KMYLR--NLNEPLMTYQ 489
                       ...:|:|:..:.:|:.|.:..|:.             |:.:|  ..|:|:...:
plant   559 VWEPSVLTLFQSLGNVYVNSVWEELLNSESRTSSASRSSGTPKSDRPRKLLVRKPGFNDPISVKE 623

  Fly   490 YHSDFIEAAKQETL--------------------NQRVNEVHKLVYKLPQPNFQMLDMVICHLTD 534
            .   ||.|...|.:                    |.|.|: .|.||:          .::|...|
plant   624 L---FIHAKYSERIFVRKAIDSQHFQAVFQEIWENVRAND-KKSVYR----------HIVCSEAD 674

  Fly   535 VSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFKNKPS 594
            |:....:...:|         :|...:...:...|:.||.:|         |..|:..|:
plant   675 VNALRGQASYTV---------SLPLSKMMQMEETLEAKFKSI---------EEEFQENPA 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	41/248 (17%)
		BAR-PH_GRAF_family	273..390	CDD:269953	28/157 (18%)
		PH	279..383	CDD:278594	24/144 (17%)
		RhoGAP	383..584	CDD:295372	50/297 (17%)
		SH3_GRAF-like	967..1020	CDD:212815
AGD1	NP_201004.2	BAR_SFC_plant	15..215	CDD:153290	33/216 (15%)
		PH	289..425	CDD:278594	28/149 (19%)
		PH_ACAP	291..429	CDD:270070	28/151 (19%)
		ArfGap	498..639	CDD:279720	26/145 (18%)
		ANK	734..>826	CDD:238125
		Ank_4	738..789	CDD:290365
		ANK repeat	740..766	CDD:293786
		ANK repeat	768..799	CDD:293786
		Ank_4	769..823	CDD:290365
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910