DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and SFC

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_196834.3	Gene:	SFC / 831171	AraportID:	AT5G13300	Length:	827	Species:	Arabidopsis thaliana

Alignment Length:	891	Identity:	172/891 - (19%)
Similarity:	307/891 - (34%)	Gaps:	306/891 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLNDFNFECIGTAQTD 86
            |||.||                     |:::.:..:|:||..|..:.......:. |.:|.|. |
plant     8 DSPMFR---------------------KQLQSMEESAEILRERSLKFYKGCRKYT-EGLGEAY-D 49

  Fly    87 DENVICESLKRFG---------AIIGNIEDE-----RE-----KMLTLADKHII-ESLEDFRKKQ 131
            .:.....:|:.||         |..|.:..:     ||     ::|....:||: :.|..|....
plant    50 GDIAFASALETFGGGHNDPISVAFGGPVMTKFTIALREIGTYKEVLRSQVEHILNDRLLQFANMD 114

  Fly   132 IGGVKENKKKFDKKTEKFCQSQERFLNM--STKKPENTI--QEADASLGMHEREYIQESLSYVLR 192
            :..|||.:|:|||.:..:.|::|:||::  .||......  ||...|..|.|    |...:.|..
plant   115 LHEVKEARKRFDKASLTYDQAREKFLSLRKGTKSDVAAALEQELHTSRSMFE----QARFNLVTA 175

  Fly   193 IQEVQERIKFEFVEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRE--NFEEA--REK 253
            :..|:.:.:|||:|.:...:...|.::...:|.......|:..:....|::||  |:|:|  .||
plant   176 LSNVEAKKRFEFLEAVSGTMDAHLRYFKQGYELLHQMEPYINQVLTYAQQSRERSNYEQAALNEK 240

  Fly   254 VTELKTK----------------------------------YMEKRTKPEEIFTKRGYLFLMEKS 284
            :.|.|.:                                  .|:...:.:....::||  |.::|
plant   241 MQEYKRQVDRESRWGSNGSNGSPNGDGIQAIGRSSHKMIDAVMQSAARGKVQTIRQGY--LSKRS 303

  Fly   285 SILKISLLEPFKATWTK-----------YYCTFKKQ-------------KREFT---------ML 316
            |.|        :..|.:           ||  ::||             :|..:         .|
plant   304 SNL--------RGDWKRRFFVLDSRGMLYY--YRKQCSKPSGSGSQLSGQRNSSELGSGLLSRWL 358

  Fly   317 QFNQMNHNFTRPE---ARDDEKLTLFSCQRRASEFEKRFCFDLTFKEKPGVVYTFQALSEKDHRY 378
            ..|...|.....|   ||....|...:.:..|.:.:.||||.:.   .|...||.||.|..|...
plant   359 SSNNHGHGGVHDEKSVARHTVNLLTSTIKVDADQSDLRFCFRII---SPTKNYTLQAESALDQMD 420

  Fly   379 WISAMDGTEPTYLA--------PG---------------KIKVSEAYHLDEAGFMFIR------- 413
            ||..:.|...:.|:        ||               ..:.||..|.....|:..|
plant   421 WIEKITGVIASLLSSQVPEQRLPGSPMGSGHHRSASESSSYESSEYDHPTTEEFVCERSFLGYNE 485

  Fly   414 ---------RCIQ--------VLEIRG------------------------LEDEGIYRKSGVGT 437
                     |.|:        :.::.|                        :|..|::|..||
plant   486 RPSRSFQPQRSIRKGEKPIDALRKVCGNDKCADCGAPEPDWASLNLGVLVCIECSGVHRNLGV-- 548

  Fly   438 KISKLLALGLNQKESD-----------DVFVDDKYRDLMESN---------TIASALKMYLR--- 479
            .|||:.:|.|:.|..:           :.|.:..:.:|:.|.         |::...::.:.
plant   549 HISKVRSLTLDVKVWEPSVISLFQALGNTFANTVWEELLHSRSAIHFDPGLTVSDKSRVMVTGKP 613

  Fly   480 ------NLNEPLMTYQY----------HSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQMLDMV 528
                  ::.|..:..:|          .|||.::|.|:..:.......|.||:|          :
plant   614 SYADMISIKEKYIQAKYAEKLFVRRSRDSDFPQSAAQQMWDAVSGNDKKAVYRL----------I 668

  Fly   529 ICHLTDVSRKYEKNKMSVFNLG-VVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFKNK 592
            :....||:..|::...|...|. |:..|.  ||:.|.|  :|.::      |.|:|      :..
plant   669 VNGDADVNYVYDQTSSSSLTLSRVILVPE--RPKREDV--LLRLR------NELLD------RTG 717

  Fly   593 PSADIKLPDATKAPSIMYPSRSSPPTRMPR-ASQIGKAASTGAMGSSSNT--------------- 641
            .|::|. |:.:...|:::.:.......|.. ..|.|  |:..|..||..|
plant   718 SSSNIS-PEGSGGSSLLHCACEKADLGMVELLLQYG--ANVNASDSSGQTPLHCCLLRGKVTIAR 779

  Fly   642 -----AGNPMFLNQQ--KIYRVVSKTNCTEPTMSSSLQNIPNGDNY 680
                 ..:|..:|::  ....:.:::|.|:|.:.:.|.: .||.|:
plant   780 LLLTRGADPEAMNREGKTALDIAAESNFTDPEVLALLSD-TNGYNH 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	49/229 (21%)
		BAR-PH_GRAF_family	273..390	CDD:269953	34/152 (22%)
		PH	279..383	CDD:278594	31/139 (22%)
		RhoGAP	383..584	CDD:295372	52/311 (17%)
		SH3_GRAF-like	967..1020	CDD:212815
SFC	NP_196834.3	BAR_SFC_plant	14..215	CDD:153290	48/206 (23%)
		PH	293..430	CDD:278594	34/151 (23%)
		PH_ACAP	295..434	CDD:270070	34/153 (22%)
		ArfGap	501..639	CDD:279720	18/139 (13%)
		ANK	711..816	CDD:238125	19/113 (17%)
		Ank_4	729..782	CDD:290365	9/54 (17%)
		ANK repeat	729..759	CDD:293786	6/31 (19%)
		ANK repeat	761..792	CDD:293786	3/30 (10%)
		Ank_4	764..816	CDD:290365	6/51 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910