DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Graf and Arhgap26

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_036017177.1	Gene:	Arhgap26 / 71302	MGIID:	1918552	Length:	823	Species:	Mus musculus

Alignment Length:	1026	Identity:	342/1026 - (33%)
Similarity:	495/1026 - (48%)	Gaps:	247/1026 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DHTSHQIKRIIKEVKDLM---SAAKILSTRMKQLAIL---------------------------- 71
            ||:|.|::.::..:.|.:   .|.|:|::.:.|..::
Mouse     3 DHSSLQLQEMLSGMLDTVGHSQAPKVLTSHLTQKKLVYKNITLTYFREESGYFWLRYMDLSSAKR 67

  Fly    72 -----LNDFNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQ 131
                 ||:|.|:|||.|:||||..|..||:.|.|::.|:||||.:|:..|.:.:|..||.|||:|
Mouse    68 KFADSLNEFKFQCIGDAETDDEMCIARSLQEFAAVLRNLEDERSRMIENASEVLITPLEKFRKEQ 132

  Fly   132 IGGVKENKKKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEV 196
            ||..:|.|||:||:|||:|.:.|:.||:|:||.|:.:||||:.:.:..:.:.:.||.||.::|||
Mouse   133 IGAAREAKKKYDKETEKYCGTLEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEV 197

  Fly   197 QERIKFEFVEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKY 261
            |||..|||||.||||:.|...|||..:|.|:|..|:...|...:|.||..||..|.:|..|..|.
Mouse   198 QERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKM 262

  Fly   262 MEKRTKPEEI--FTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHN 324
            .|...:.:.|  :|..|||::.||         ..|..:|.|:|||:::..::.||:.|:|.:..
Mouse   263 KENPLEHKTISPYTMEGYLYVQEK---------RHFGTSWVKHYCTYQRDSKQITMVPFDQKSGG 318

  Fly   325 FTRPEARDDEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEP 388
                :..:||.:||.||.||.:: .|||||||:...::|||: |.|||||:|.|.|:.||||.||
Mouse   319 ----KGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVI-TMQALSEEDRRLWMEAMDGREP 378

  Fly   389 TYLAPGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESD 453
            .|.:....:......||..||..||:||..:|.||:.::|:||..||.:::.|||::.::.|.:.
Mouse   379 VYNSNRDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKAAS 443

  Fly   454 DVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLP 518
            :...|....  .|..|:.||||.|||.|..|||.||:...||:|||.|....||:|:|.||::||
Mouse   444 ETETDICAE--WEIKTVTSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQETRVSEIHSLVHRLP 506

  Fly   519 QPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILID 583
            :.|.|||.:::.||.:|:..:::|.|:|.|||||||||||||:||:||||:||||.||||.|||:
Mouse   507 EKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIE 571

  Fly   584 NYERIFKNKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFL 648
            |:|:||...|  |:.|.:|....|....|.|.||:...|                      |:.|
Mouse   572 NHEKIFNTVP--DVPLTNAQLHLSRKKSSDSKPPSCSKR----------------------PLTL 612

  Fly   649 NQQKIYRVVSKTNCTE---PTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILS 710
                 :..|..|...|   ..::|||:::.:..|..|.|::          ||.|
Mouse   613 -----FHAVPSTEKQEQRNSIINSSLESVSSSANSILNSSS----------SLQP---------- 652

  Fly   711 PTIGSINNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLM 775
                   ||:                                          ||.||.
Mouse   653 -------NLN------------------------------------------SSDSNL------- 661

  Fly   776 TTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLH 840
               :.|..|..||                      .|||.:.....   |.|.|....|
Mouse   662 ---DVVKPSRPSS----------------------LPPNPSPTSPL---SPSWPMFSAP------ 692

  Fly   841 SYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQ 905
                    |..||||::||:.|...|::.......:.|.           ||...::.:|:.|
Mouse   693 --------SSPMPTSSTSSDSSPIRSVAGFVWFSVAAVV-----------LSLAWSSLHAVFS-- 736

  Fly   906 NSSLSPHLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRT 970
                           :....:|     |         :|...:..:|....::.|.||...:.:.
Mouse   737 ---------------LLVNFVP-----C---------HPNLHLLFDRPEEAVREDSSTPFRKAKA 772

  Fly   971 LYACMGESEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHL 1021
            ||||..|.:.||||....:..||..|.|||||:||||||||||||||||.|
Mouse   773 LYACQAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	90/230 (39%)
		BAR-PH_GRAF_family	273..390	CDD:269953	49/117 (42%)
		PH	279..383	CDD:278594	39/104 (38%)
		RhoGAP	383..584	CDD:295372	96/200 (48%)
		SH3_GRAF-like	967..1020	CDD:212815	32/52 (62%)
Arhgap26	XP_036017177.1	BAR	61..234	CDD:416402	81/172 (47%)
		BAR-PH_GRAF_family	276..380	CDD:269953	49/117 (42%)
		RhoGAP_Graf	373..572	CDD:239839	96/200 (48%)
		SH3_GRAF	768..823	CDD:212997	33/54 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I2290
eggNOG	1	0.900	-	-		E1_KOG1451
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36349
Inparanoid	1	1.050	604	1.000	Inparanoid score	I931
Isobase	1	0.950	-	0	Normalized mean entropy	S3410
OMA	1	1.010	-	-		QHG45894
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	1	1.000	-	-		FOG0003780
OrthoInspector	1	1.000	-	-		otm44089
orthoMCL	1	0.900	-	-		OOG6_101903
Panther	1	1.100	-	-	O	PTHR12552
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820