DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Graf and Chn2

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001157112.1	Gene:	Chn2 / 69993	MGIID:	1917243	Length:	468	Species:	Mus musculus

Alignment Length:	483	Identity:	123/483 - (25%)
Similarity:	198/483 - (40%)	Gaps:	123/483 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 SYVLRIQ-------------EVQERIKF-----------EFVEILLAFISGWLVFYHTAHE---- 224
            ||:.::|             ||:.|.|:           |..:.||..:.|..:...:..:
Mouse    28 SYLYQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCY 92

  Fly   225 --------QAEDHRDYLQDLRHKVQKTRENFEEAREKVTE-LKTKYMEKRTKPEEIFTKR----- 275
                    |..::| ...|.:|.|.:.|  ||...:.||: |.|.|:|  ||..|...|.
Mouse    93 TLALRFGNQTLNYR-LFHDGKHFVGEKR--FESIHDLVTDGLITLYIE--TKAAEYIAKMTTNPI 152

  Fly   276 ----GYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARDDEKL 336
                ||..|:.:....::|                 :.|.|......:...|.       ..||:
Mouse   153 YEHIGYATLLREKVSRRLS-----------------RSKNESRKASVSNEEHT-------PVEKI 193

  Fly   337 TLFSCQRRA--SEFEKRFCFDLTFKEKPGVVYTFQALSEKDH--RYWISAMDGT----------- 386
            :  |..|||  :..:..|.::.|...|   |:||:.    .|  .|..:.|.|.
Mouse   194 S--SLVRRAALTHNDNHFNYEKTHNFK---VHTFRG----PHWCEYCANFMWGLIAQGVRCSDCG 249

  Fly   387 ----------EPTYLAPGKIKVSEAYHLDEAGF---------MFIRRCIQVLEIRGLEDEGIYRK 432
                      .|....|...::.:.|..|....         |.:..||:.:|.|||:.||:||.
Mouse   250 LNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRV 314

  Fly   433 SGVGTKISKLLALGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEA 497
            ||....|..:........|..|:.. :.|.|:   |.|..|||:|.|:|..|::||..:|.||||
Mouse   315 SGFTEHIEDVKMAFDRDGEKADISA-NIYPDI---NIITGALKLYFRDLPIPIITYDTYSKFIEA 375

  Fly   498 AKQETLNQRVNEVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPRE 562
            ||....::|:..||:::..||..:::.|..::.||..|:...:.|.|:..|||:||||||:||.|
Mouse   376 AKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNLMNAENLGIVFGPTLMRPPE 440

  Fly   563 ESVAAIL-DIKFNNIVINILIDNYERIF 589
            :|....| |:::..:::.|||:|.:.:|
Mouse   441 DSTLTTLHDMRYQKLIVQILIENEDVLF 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	13/80 (16%)
		BAR-PH_GRAF_family	273..390	CDD:269953	25/150 (17%)
		PH	279..383	CDD:278594	19/107 (18%)
		RhoGAP	383..584	CDD:295372	71/231 (31%)
		SH3_GRAF-like	967..1020	CDD:212815
Chn2	NP_001157112.1	SH2_a2chimerin_b2chimerin	52..138	CDD:198215	20/90 (22%)
		C1_1	215..267	CDD:278556	9/58 (16%)
		RhoGAP_chimaerin	275..468	CDD:239837	68/196 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030