DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and Arhgap10

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_038953914.1	Gene:	Arhgap10 / 688429	RGDID:	1588859	Length:	823	Species:	Rattus norvegicus

Alignment Length:	1023	Identity:	342/1023 - (33%)
Similarity:	496/1023 - (48%)	Gaps:	212/1023 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            ||:||||.:|.:|||.|||.:..||.||:.|:..||.:||:.|:|::|.|.||...::.|..|.|
  Rat     2 GLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSAAQRKFAHSLRD 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.||.||.|:||||..|..||:.|...:.|:|::||.|.....:.:|:.||.|||:|:|.|||.|
  Rat    67 FKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            |||||:||:.....::.|.:|.:|.:..:||||..:..:.:.:.:.||.||.::||:|||.||||
  Rat   132 KKFDKETERNYSLIDKHLTLSARKKDTHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEF 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYME--KRTK 267
            ||.:|:|..|...|||..||.::|...|..:|:..:|.||..||..|.:|.||..|..:  |..|
  Rat   197 VEPMLSFFQGMFTFYHQGHELSKDFNHYKTELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQK 261

  Fly   268 PEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARD 332
            ....||..|||::.||..       .||.::|.|:||.::|..::|.|:.|...:..    :..|
  Rat   262 RASQFTAEGYLYVQEKRP-------APFGSSWVKHYCMYRKTAKKFNMIPFEHRSGG----KLGD 315

  Fly   333 DEKLTLFSC-QRRASEFEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTY------ 390
            .|...|..| :|.....::|||||:...::|||..|.||.||::.:.|:.|:.|.|..:
  Rat   316 GEAFFLKECTKRHIDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRA 380

  Fly   391 LAPGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDV 455
            :.|   :......||:.||..:|:||..:|.||:.|:|:||..||.:|:.:||::.::.|..:::
  Rat   381 IVP---RPEGGAQLDKMGFTILRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEL 442

  Fly   456 FVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQP 520
            .:::...  .|..|:.||||.|||:|.||||||:.|.|||..||..:...||:.:|.||:|||:.
  Rat   443 DLENSTD--WEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVSAIHFLVHKLPEK 505

  Fly   521 NFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNY 585
            |.:|||:::.|||:||...::|.|:|.||||||||||:||:||:||||:|:||.|||:.|||:|:
  Rat   506 NKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENH 570

  Fly   586 ERIFKNKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQ 650
            |:||:..|......|....|         |||...||.|:                      ...
  Rat   571 EKIFRTSPDTTFAEPTCLSA---------SPPNAPPRQSK----------------------RQG 604

  Fly   651 QKIYRVVSKTN-CTEPTMSSSLQNIPNGDNYA-LGSNAMNSSGGAQCISLSPPMHMLNGILSPTI 713
            |:..|.|:..| |.|         :..||:.: |..:..:||..    |||.|        |||
  Rat   605 QRTKRPVAVYNLCLE---------LEEGDSPSPLKEDPPSSSQD----SLSTP--------SPT- 647

  Fly   714 GSINNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTA 778
                         ||.....|    .||...:.|:.|...                     ..||
  Rat   648 -------------TSAAHGPP----GPDGNHLAADRGNCG---------------------DATA 674

  Fly   779 NPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYG 843
            ...:|:..|...:.|..|....|||...    :||:              |:..|
  Rat   675 TTPSQTRPSMVQWLNMQSPTTPSSNPAG----TPPS--------------PRMSP---------- 711

  Fly   844 QTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSS 908
                 .||.|.:      |:.|.|.                          ....:.|.:||...
  Rat   712 -----FPLSPAA------SIVDKLP--------------------------ECRSWVLHASQWGR 739

  Fly   909 LSPHLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRTLYA 973
                  ..|.:..|.          |..|:....:    :||:..:  |.|       :.|.:|.
  Rat   740 ------KFCIKKTTE----------GMAAASGVLW----VHRHHSL--INR-------KARAVYP 775

  Fly   974 CMGESEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHL 1021
            |..|...|||||...|..:|:.|.|||||:||||||.||||:|||:.|
  Rat   776 CEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	89/205 (43%)
		BAR-PH_GRAF_family	273..390	CDD:269953	38/117 (32%)
		PH	279..383	CDD:278594	31/104 (30%)
		RhoGAP	383..584	CDD:295372	92/206 (45%)
		SH3_GRAF-like	967..1020	CDD:212815	30/52 (58%)
Arhgap10	XP_038953914.1	BAR_GRAF2	19..225	CDD:153319	89/205 (43%)
		BAR-PH_GRAF_family	267..372	CDD:269953	37/115 (32%)
		RhoGAP_Graf	367..569	CDD:239839	92/206 (45%)
		PHA03247	<579..716	CDD:223021	48/260 (18%)
		SH3_GRAF2	769..822	CDD:212998	30/52 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339956
Domainoid	1	1.000	237	1.000	Domainoid score	I2240
eggNOG	1	0.900	-	-		E1_KOG1451
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1242
OMA	1	1.010	-	-		QHG45894
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	1	1.000	-	-		FOG0003780
OrthoInspector	1	1.000	-	-		otm46182
orthoMCL	1	0.900	-	-		OOG6_101903
Panther	1	1.100	-	-	LDO	PTHR12552
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770