DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Graf and chn2

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_699642.6	Gene:	chn2 / 570999	ZFINID:	ZDB-GENE-091020-5	Length:	466	Species:	Danio rerio

Alignment Length:	472	Identity:	118/472 - (25%)
Similarity:	191/472 - (40%)	Gaps:	128/472 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 QEVQERIKF-----------EFVEILLAFISGWLVFYHTAHE------------QAEDHRDYLQD 235
            ||::.|.|:           |..:.|||...|..:...:..:            |..::| ...|
Zfish    47 QEMESRPKYYGREFHGLISREQADELLAGTEGAYLIRESQRQPGTYTLALRFGGQTLNYR-LFYD 110

  Fly   236 LRHKVQKTRENFEEAREKVTE-LKTKYMEKRTKPEEIFTKRGYLFLMEKSSILKISLLEPFKATW 299
            .:|.|.:.|  ||...:.||: |.|.|:|  ||..|...                      |.|.
Zfish   111 GKHFVGEKR--FESVHDLVTDGLITLYIE--TKAAEYIA----------------------KMTT 149

  Fly   300 TKYYCTFKKQKREFTMLQFNQMNH--NFTRPEAR-----DDEKLTLFSCQRRASEFEKRFCFDLT 357
            ...|     |...:|.|..:::.|  |.||.|.:     .|||::.....||.           |
Zfish   150 NPIY-----QHLGYTSLLRDKITHRLNRTRSEPKKVTFQQDEKISPSPLSRRT-----------T 198

  Fly   358 FKEKPGVVYTFQALSEKDHRYWISAMDGTE----------------------------------P 388
            .|:.|.....:    ||.|.:.:....|..                                  |
Zfish   199 LKDGPEKHCNY----EKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKLVP 259

  Fly   389 TYLAPGKIKVSEAYHLDEAGF---------MFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLA 444
            :...|...::.:.:..|....         |.:..||:.:|.|||:.||:||.||....|..:..
Zfish   260 SDCQPDLRRIKKVFSCDLTTLVKAHNTPRPMVLDMCIREIEHRGLKSEGLYRVSGFTEHIEDVRL 324

  Fly   445 LGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNE 509
            ......|..|:.. :.|.|:   |.||.|||:|||:|..|::||..:|.||:|||....:.|:..
Zfish   325 SFDRDGEKADISA-NIYPDI---NIIAGALKLYLRDLPIPVITYDVYSRFIQAAKITDPDSRLEA 385

  Fly   510 VHKLVYKLPQPNFQMLDMVICHLTDVSRKYEK-NKMSVFNLGVVFGPTLLRPRE-ESVAAILDIK 572
            ||..:.:||..:::.|..::.||..|: .||| |.|:..|||:||||||:||.: .::..:.|::
Zfish   386 VHDGLLQLPPAHYETLRYLMTHLKRVT-MYEKDNYMNSENLGIVFGPTLMRPPDLNTLTTLNDMR 449

  Fly   573 FNNIVINILIDNYERIF 589
            :..:::.:||::.:.:|
Zfish   450 YQKLIVQLLIEHEDILF 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	11/61 (18%)
		BAR-PH_GRAF_family	273..390	CDD:269953	24/157 (15%)
		PH	279..383	CDD:278594	22/110 (20%)
		RhoGAP	383..584	CDD:295372	69/245 (28%)
		SH3_GRAF-like	967..1020	CDD:212815
chn2	XP_699642.6	SH2_a2chimerin_b2chimerin	52..138	CDD:198215	21/90 (23%)
		C1_1	213..265	CDD:278556	3/51 (6%)
		RhoGAP_chimaerin	273..466	CDD:239837	66/197 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030