DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Graf and arhgap42a

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_021324560.1	Gene:	arhgap42a / 566275	ZFINID:	ZDB-GENE-030131-8077	Length:	900	Species:	Danio rerio

Alignment Length:	1040	Identity:	351/1040 - (33%)
Similarity:	499/1040 - (47%)	Gaps:	169/1040 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            ||..|||.:..:|||||||.|..||.|||.|:..||.:||:...|:||.|.||..:::.:..|.|
Zfish     2 GLPALEFSDSFLDSPDFRERLKCHEIELDRTNKFIKELIKDGNMLISALKSLSAAVQKFSQSLQD 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.|||||.|:||||..|.:|.|.|..::..:|:||.:::..||..:|..||.|||:|||..||.|
Zfish    67 FQFECIGDAETDDEINIAQSFKEFSQLLNTVEEERRRLIQNADDVLITPLEKFRKEQIGAAKEGK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            |||||:|||:....|:.|::|::|.|:.:||||..:....:.:...||.||.:|||||||.||||
Zfish   132 KKFDKETEKYYTVLEKHLSLSSRKKESLLQEADTQISKERQVFYDASLEYVFKIQEVQERKKFEF 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTEL--KTKYMEKRTK 267
            ||.||||:.|...|||..:|.|.:...|.|.|:..:|.||.|||..|::|..|  :.:..|:..|
Zfish   197 VEPLLAFLQGLFTFYHEGYELAHEFEPYKQQLQFNLQNTRNNFESTRQEVENLMRRIRSAEQDFK 261

  Fly   268 PEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQF-----NQMNHNFTR 327
            ....:|..|:|::.||         .|...|||::|||::|..:.|||...     .:.|.....
Zfish   262 APGQWTMEGFLYVQEK---------RPLGCTWTRHYCTYEKGTKMFTMSNSELKTGGKQNGLIMS 317

  Fly   328 PEARDDEKLTLFSC-QRRASEFEKRFCFDLTFKE--------------------KPGVVYTFQAL 371
            |    .|...|.|| :||....:||||||:...|                    :.|:: |.|:|
Zfish   318 P----PEMFKLKSCIRRRTDSIDKRFCFDIEVVERGNPSEGPLFSYLQCFYKAHRHGII-TLQSL 377

  Fly   372 SEKDHRYWISAMDGTEPTYLAPGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVG 436
            ||.:.|.|:.||||.||.|..|..:...|...|:||||.|:|:||:.:|.||:...|:||..||.
Zfish   378 SESNRRLWMEAMDGKEPIYTLPALLSKKEETFLNEAGFNFVRKCIESVEARGINTLGLYRIGGVN 442

  Fly   437 TKISKLLALGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQE 501
            :|:.:|:......|...|:.:|.   |..::.||.|.||.|||.|.||||||:.|.|||.|.|.:
Zfish   443 SKVQRLMTSVFAAKAPADLDLDP---DTWDNKTITSGLKNYLRCLAEPLMTYRLHKDFIMAVKSD 504

  Fly   502 TLNQRVNEVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVA 566
            ..|.||..||.||||||..|.:||:::|.||..||...:||.|:|.||||:|||||:|.:||:||
Zfish   505 DQNYRVCAVHALVYKLPDKNKEMLNLLIKHLHVVSTHSQKNLMTVSNLGVIFGPTLMRSQEETVA 569

  Fly   567 AILDIKFNNIVINILIDNYERIFKNKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAAS 631
            |:::|||.|||:.|||:||::||...|..::.||         :|...|......|.|:    |.
Zfish   570 AMMNIKFQNIVVEILIENYDKIFHQAPDPNVPLP---------HPQSHSQSRGGARRSK----AI 621

  Fly   632 TGAMGSSSNTAGNPMFLNQQKIYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCI 696
            ..:.||..:....|..|         ...:....|.|||..:.|.|...:|.|::...:..::..
Zfish   622 CLSSGSRKSRGLYPPAL---------CLADADSDTFSSSPSSTPMGSMESLSSHSSEQNSCSKTG 677

  Fly   697 SLSPPMHMLNGILSPTIGSINNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVP 761
            |.|...|..:|.|
Zfish   678 SPSRNKHKASGSL---------------------------------------------------- 690

  Fly   762 VSSTSNFRHPEYLMTTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSA 826
                        ..||.:|.|....|....|:..|:....:|:          |....|..|.::
Zfish   691 ------------CWTTPSPSTNGPKSPACTTSPDSSSKEDANK----------TDGEWEEALSTS 733

  Fly   827 SGPQQHPPVQRGLHSYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHL 891
            .|.:..|..:....:.|:|......:.:.:|.::..:.:...|.:|...|:|:.|......:.|:
Zfish   734 PGDRSSPASELLHRTLGETAEDQRSLSSCSSLTSLHISEGFRSCHGSIQSLVSRSQRDSLKSLHM 798

  Fly   892 SARNTNDYALISSQNSSLSPHLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQ 956
            ......|.......:|:.:.:..|  ..||...   :....|...:..:|         .||
Zfish   799 PDLPPKDGMRFRDDSSASNGYQRP--GSVVACR---AAIFECPVISQPTT---------GRD--- 846

  Fly   957 IKRDLSTGTARVRTLYACMGESEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHL 1021
                       .:.||:|..|...||||......:||..|.||||||.|.:||||||||||||:|
Zfish   847 -----------AKALYSCQAEHSHELSFPQGAHFSNVYPSVEPGWLQATFDGKTGLIPENYVEYL 900

Fly 1022 1021
Zfish 901 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	97/205 (47%)
		BAR-PH_GRAF_family	273..390	CDD:269953	45/142 (32%)
		PH	279..383	CDD:278594	36/129 (28%)
		RhoGAP	383..584	CDD:295372	99/200 (50%)
		SH3_GRAF-like	967..1020	CDD:212815	29/52 (56%)
arhgap42a	XP_021324560.1	BAR	19..225	CDD:325158	97/205 (47%)
		BAR-PH_GRAF_family	267..396	CDD:269953	45/142 (32%)
		RhoGAP_Graf	389..587	CDD:239839	99/200 (50%)
		Pneumo_att_G	<674..>757	CDD:114270	20/156 (13%)
		SH3_GRAF3	846..900	CDD:212999	31/67 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579769
Domainoid	1	1.000	230	1.000	Domainoid score	I2379
eggNOG	1	0.900	-	-		E1_KOG1451
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1343
OMA	1	1.010	-	-		QHG45894
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26315
orthoMCL	1	0.900	-	-		OOG6_101903
Panther	1	1.100	-	-	O	PTHR12552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770