DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and abr

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001355623.1	Gene:	abr / 565190	ZFINID:	ZDB-GENE-070705-146	Length:	1061	Species:	Danio rerio

Alignment Length:	665	Identity:	155/665 - (23%)
Similarity:	251/665 - (37%)	Gaps:	193/665 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSPDF-----------------RENLNRHEKELDHTSHQIKRIIKE------------------V 51
            |.|||                 .|.::.....:.....:.::::|:                  .
Zfish   460 DHPDFPLLQDALRISQNFLSSINEEIDPRRTAVTTPKGEARQLVKDGFLVEVSEGTRKLRHVFLF 524

  Fly    52 KDLMSAAKILST---RMKQLA----ILLNDFNFECIGTAQTDDENVICESLKRFGAIIGNIEDER 109
            .||:..||:..|   |.:|..    |.|.|.:|      ||.||:                 |..
Zfish   525 TDLLLCAKMKKTAVGRHQQYECKWYIPLADLSF------QTLDES-----------------DSL 566

  Fly   110 EKMLTLADKHIIESLEDFRKKQIGGVKENKKKFDKKTEKFCQSQERFLNMSTKKPENTIQEADAS 174
            ..:.|||: |.||.:    |.:|..:|...:| :||.:|   .|.|.::...||    :.|.::.
Zfish   567 PHVQTLAE-HEIEEM----KIKISSIKSEIQK-EKKAQK---GQSRNVDRLRKK----MNEQESC 618

  Fly   175 LGMHE-----REYIQESLSYVLRIQEVQERIKF-EFVEIL--------------LAFISGWLVFY 219
            |.::.     |.:.:...||:..:....||.:: |.::.|              |..::|.....
Zfish   619 LLLNSPTIPFRIHNKHGKSYLFLLSSDYERSEWRESIQKLQKKDLQACVLSSVELQVLTGSCFKL 683

  Fly   220 HTAH----------EQAEDHRDYLQDLRHKVQKTRENFEEAREK------------VTELKTKYM 262
            .|.|          |::.....:|..:.||.    ..|:|:...            |::.||:..
Zfish   684 RTVHNIPVTSNKDDEESPGLYGFLHVIVHKA----TGFKESANLYCTLEVDSFGYFVSKAKTRVF 744

  Fly   263 EKRTKPEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTR 327
            ...|:|:   ....:...:|.|..|:|...|       |.|...|..|.:         |....:
Zfish   745 RDTTEPQ---WNEEFEIELEGSQCLRILCYE-------KCYDKSKLNKDD---------NEIVDK 790

  Fly   328 PEARDDEKLTLFSCQRR------------ASEFEKRFCF-DLTFKEKPGVVYTFQALSEKDHRYW 379
            ...:...:|...:.|.:            ..||..:|.. ||:.|..|         |:|.
Zfish   791 IMGKGQVQLDPQTVQSKNWHMDVIEMNGIKVEFSMKFTSRDLSLKRTP---------SKKQ---- 842

  Fly   380 ISAMDGTEPTYLAPGKIKVSEAYHLDEAGFMFI-RRCIQVLEIRGLEDEGIYRKSGVGTKISKL- 442
             |.:.|          :|:|.....:.:...:| |:||:.:|.||:::.||||.|||.|.|..|
Zfish   843 -SGVFG----------VKISVVTKRERSKVPYIVRQCIEEVEKRGIDEVGIYRISGVATDIQALK 896

  Fly   443 LALGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRV 507
            .|...|.|:...:..|      |:.|.||..||:|.|.|.|||:|.:.:..|:|.........:.
Zfish   897 AAFDANTKDILMMLSD------MDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGISLSDPAAKE 955

  Fly   508 NEVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPRE-ESVAAIL-- 569
            |.:..|:..||.||......::.||..|:.|...||||:.||..|||||||||.| ||..|.:
Zfish   956 NCMMHLLRSLPDPNLITFLTLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSESESSKAQITL 1020

  Fly   570 --DIKFNNIVINILI 582
              ||..::::..:.:
Zfish  1021 ASDIWSHDVMAQVQV 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	49/260 (19%)
		BAR-PH_GRAF_family	273..390	CDD:269953	23/129 (18%)
		PH	279..383	CDD:278594	22/116 (19%)
		RhoGAP	383..584	CDD:295372	70/207 (34%)
		SH3_GRAF-like	967..1020	CDD:212815
abr	NP_001355623.1	Bcr-Abl_Oligo	3..74	CDD:312543
		RhoGEF	295..483	CDD:214619	4/22 (18%)
		PH-like	477..661	CDD:354315	44/219 (20%)
		C2_ABR	707..827	CDD:176068	24/142 (17%)
		RhoGAP_Bcr	846..1042	CDD:239852	70/206 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030