DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Graf and arhgap29a

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_693227.4	Gene:	arhgap29a / 564805	ZFINID:	ZDB-GENE-030131-9510	Length:	1344	Species:	Danio rerio

Alignment Length:	972	Identity:	203/972 - (20%)
Similarity:	346/972 - (35%)	Gaps:	266/972 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GGKNV--RRGLEP---LEFEE-------CIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLM 55
            |||.:  ||.||.   |:.||       |:.|....|.:|.:.:.|:   ..||:.::.:....:
Zfish   395 GGKQLEKRRKLEEEALLKAEEAQDHYKLCVTDVGVKRVDLAKTKSEI---LTQIRELVFQCDLTL 456

  Fly    56 SAAKILSTRMKQLAILLNDFNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHI 120
            .|..:...:|:|..:.....||:.           :||:.|.:..  |....|..|.|. :|:..
Zfish   457 KAVTVNWFQMQQAQVASLPINFQS-----------LCENSKLYEP--GLCYTEFVKSLP-SDRSR 507

  Fly   121 IESLE-DFRKKQIGGVKENKKKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASL---GMHERE 181
            :||.. |.......|:|..............|....||  |..:.|:.:|...|.:   ..|...
Zfish   508 VESFSFDISSTHNTGLKRAVNSTPAALVHLSQVSGDFL--SADEVESHVQARTAKMPDGRSHSTT 570

  Fly   182 YIQESLSYVLRIQEVQERIKFEFVEILLAFISGWLVFYHTAHE------------QAEDHRDYLQ 234
            .:|     .||||                   |....:.|:.:            .:.:.|....
Zfish   571 DVQ-----ALRIQ-------------------GPFRVWRTSSQGGGMCSDSESAGGSSESRSMDS 611

  Fly   235 ------DLRHKVQKTRENFEEAREKVTELKTKYMEKRTKPEEIFTKRGYLFLMEKSSILKISLLE 293
                  |.:.::.:|...       .|......:::|..|..  :..|...::.:::    |...
Zfish   612 PTASPGDFKRRLPRTPST-------GTMSSADDLDEREPPSP--SDNGLSEMVTEAA----SSPG 663

  Fly   294 PFKAT-WTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARDDEKLTLF----------SCQRRASE 347
            ||:.| .:|...|.|.:|..             ...:.|:.:.|.:|          :|.::..|
Zfish   664 PFRNTQMSKAAQTHKLRKLR-------------APSKCRECDSLVVFHGAECEECSLACHKKCLE 715

  Fly   348 FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGKIKVSEAYHLDEAGFMFI 412
               ........|:..|.::.|             |:|..:....:|..|.            ..|
Zfish   716 ---TLAIQCGHKKLQGKLHLF-------------AIDFAQAAKNSPDGIP------------FII 752

  Fly   413 RRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDKYRDLMESNTIASALKMY 477
            ::|...:|.|.|..:||||.:|..:::.||.....|.|  |.|.:.|.|     .:.|::.||:|
Zfish   753 KKCTSEIENRALNIKGIYRVNGAKSRVEKLCQAFENGK--DLVELSDLY-----PHDISNVLKLY 810

  Fly   478 LRNLNEPLMTYQYHSDFIEAAKQE------------------------TLNQRVNEVHKLVYKLP 518
            ||.|.|||:.::|::|||..||:.                        .||:.:.::..|:.:||
Zfish   811 LRQLPEPLILFRYYNDFIGLAKESQSIIVDEVEASRGCPTSDTPQISVELNRVLFKIKDLLRQLP 875

  Fly   519 QPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPR----EESVAAILDIKFNNIVIN 579
            ..:::.|..:|.||..||.:.::|||:..|||::|||||::||    |.|:::::|..:..:::.
Zfish   876 PAHYKTLQFLIQHLHRVSERADENKMTSSNLGIIFGPTLIKPRQADAEVSLSSLVDYPYQALIVE 940

  Fly   580 ILIDNYERIFKN-----KPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKA--------AS 631
            :||.:||.||..     .||:    |.|..:| :...||.:|..:..:.|:..|:        .|
Zfish   941 LLIRHYEMIFDTPLSPLPPSS----PVAESSP-LPVKSRFTPQEKGQQLSRHSKSLVDIKEQQQS 1000

  Fly   632 TGAMGSSSNTAGNPMFL---------NQQKIYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAM 687
            ...|....::....|.|         ...|.:..|...:.....:|||:..:.|       |..:
Zfish  1001 KAKMYKRHSSVIPSMHLMDEVKEGKIRSDKDFAAVGDKSDMNKLLSSSVPEMRN-------SPGL 1058

  Fly   688 NSSGGAQCISLSPPMHML--NGILSPT--------IGSINNLHTISKNETSTRRYV--------- 733
            ........:.|.||...|  ..|..|.        :...|..:::.:.||.:|..|
Zfish  1059 TRRNHVTRVQLRPPRPKLVSRPISMPAERLLNLSKVDECNVKNSVEQEETHSRDPVIEEVSEEEK 1123

  Fly   734 PDTEIAPDYGIIGANNGGVTLQS----------HHAV-----PVSSTSNFRHPEYLMTTANPVTQ 783
            |.:.....|     ....:..|:          ||.:     ||.|.||..:     ...:.:|.
Zfish  1124 PKSRAGNHY-----RKSYIDTQTLRRTWDKQYKHHDITPKTCPVDSGSNDTN-----VHTSSLTS 1178

  Fly   784 SGSSSHI-----------YTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPP 834
            |..|.|.           ||.....|.......::|...|..||.|..|.|....|....||
Zfish  1179 SSFSEHSKSPSTVLANRPYTIAVRPGRTLRREGNISEFCPVPTAFRPPRTLQPPPGTFYKPP 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	39/221 (18%)
		BAR-PH_GRAF_family	273..390	CDD:269953	19/127 (15%)
		PH	279..383	CDD:278594	16/114 (14%)
		RhoGAP	383..584	CDD:295372	66/228 (29%)
		SH3_GRAF-like	967..1020	CDD:212815
arhgap29a	XP_693227.4	BAR	230..484	CDD:299863	23/102 (23%)
		C1	675..721	CDD:197519	8/61 (13%)
		RhoGAP	733..945	CDD:295372	68/243 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940