DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and Arhgap42

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_576354.3	Gene:	Arhgap42 / 500943	RGDID:	1564081	Length:	875	Species:	Rattus norvegicus

Alignment Length:	1025	Identity:	365/1025 - (35%)
Similarity:	520/1025 - (50%)	Gaps:	164/1025 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            ||..|||.:..:|||||||.|..||.||:.|:..||.::|:...|:.|.:.||..:::.:..|.|
  Rat     2 GLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELLKDGSLLIGALRNLSMAVQKFSQSLQD 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.|||||.|:||||..|.:|||.|..::..:|:||.:::..|:..:|..||.|||:|||..|:.|
  Rat    67 FQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKDGK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            |||||::||:....::.||:|.||.|:.:||||:.:|...:.:.:.||.||.:||||||:.||||
  Rat   132 KKFDKESEKYYSILDKHLNLSAKKKESHLQEADSQIGREHQNFYEASLEYVFKIQEVQEKKKFEF 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTEL--KTKYMEKRTK 267
            ||.||:|:.|...|||..:|.|::...|.|.|:..:|.||.|||..|::|..|  :.|...:..:
  Rat   197 VEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFESTRQEVERLMQRMKAANQDYR 261

  Fly   268 PEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTM-----LQFNQMNHNFTR 327
            |...:|..|||::.||         .|...||||:|||:.|..:.|||     ....:||...|
  Rat   262 PPSQWTMEGYLYVQEK---------RPLGFTWTKHYCTYDKGSKMFTMSVSDVKASGKMNGLVT- 316

  Fly   328 PEARDDEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYL 391
               ...|...|.||.||.:: .:||||||:...|:.|:: |.||.||.:.:.|:.||||.||.|.
  Rat   317 ---GSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGII-TLQAFSEANRKLWLEAMDGKEPIYT 377

  Fly   392 APGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVF 456
            .|..|...|..:|:||||.|:|:|||.:|.||:...|:||..||.:|:.||:....:.|...|:.
  Rat   378 LPAIISKKEEMYLNEAGFNFVRKCIQAVETRGINILGLYRIGGVNSKVQKLMNTTFSPKSPPDMD 442

  Fly   457 VDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPN 521
            :|   .:|.::.||.|.||.|||.|.||||||:.|.|||.|.|.:..|.||..||.||:|||:.|
  Rat   443 ID---IELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKN 504

  Fly   522 FQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYE 586
            .:|||::|.||..||...::|.|::.||||:|||||:|.:||:|||:::|||.|||:.|||::||
  Rat   505 REMLDILIKHLLKVSLHSQQNLMTISNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYE 569

  Fly   587 RIFKNKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQ 651
            :||...|..:|.||..        .|||.  :|..||.    ..|||    |....|.
  Rat   570 KIFHTAPDPNIPLPQP--------QSRSG--SRRTRAI----CLSTG----SRKPRGR------- 609

  Fly   652 KIYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSI 716
                   .|.|...         |:.|:|                |.||.        |..:|||
  Rat   610 -------YTPCLAE---------PDSDSY----------------SSSPD--------STPMGSI 634

  Fly   717 NNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANPV 781
            .:|.:.|..:.||.:   .|...|     ...:||:..     :...|:||.:....|.|| :|.
  Rat   635 ESLSSHSSEQNSTTK---STSCQP-----REKSGGIPW-----IAAPSSSNGQKSLGLWTT-SPE 685

  Fly   782 TQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYGQTK 846
            :.|...: ..|:..|...:.::..|..:||||...::|        ||.       ||....::.
  Rat   686 SSSREDA-TKTDVESDCQSVASVTSPGDVSPPIDLVKK--------GPY-------GLSGLKRSS 734

  Fly   847 HYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSSLSP 911
            ..|.|...|.:..|.|...|:.|...:||.                          .|..::.:|
  Rat   735 ASSSLRSISAAEGNKSYSGSIQSLTSIGSK--------------------------ESPKATPNP 773

  Fly   912 HLGP-TCDEVVTATTLPSVSLSCGGTASESTEYPPS----KMHRNRDVNQIKRDLSTGTARVRTL 971
            .|.| .|..:...|           .:|...:.|.|    |.....:...:| .:|:| .:.:.:
  Rat   774 ELPPKMCRRLRLDT-----------ASSNGYQRPGSVVAAKAQLFENAGSLK-PVSSG-RQAKAM 825

  Fly   972 YACMGESEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHL 1021
            |:|..|...||||....|.:||..|.|||||:.|..|:|||:|||||..|
  Rat   826 YSCKAEHSHELSFPQGAIFSNVHPSVEPGWLKATYEGRTGLVPENYVVFL 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	91/205 (44%)
		BAR-PH_GRAF_family	273..390	CDD:269953	47/122 (39%)
		PH	279..383	CDD:278594	37/109 (34%)
		RhoGAP	383..584	CDD:295372	100/200 (50%)
		SH3_GRAF-like	967..1020	CDD:212815	26/52 (50%)
Arhgap42	XP_576354.3	BAR_GAP10-like	19..225	CDD:153318	91/205 (44%)
		BAR-PH_GRAF_family	267..376	CDD:269953	47/122 (39%)
		PH	267..369	CDD:278594	41/115 (36%)
		RhoGAP	369..567	CDD:295372	100/200 (50%)
		SH3_GRAF3	821..875	CDD:212999	26/53 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339958
Domainoid	1	1.000	237	1.000	Domainoid score	I2240
eggNOG	1	0.900	-	-		E1_KOG1451
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1242
OMA	1	1.010	-	-		QHG45894
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101903
Panther	1	1.100	-	-	O	PTHR12552
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.770