DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Graf and OPHN1

DIOPT Version :9

Sequence 1:NP_001285296.1 Gene:Graf / 32522 FlyBaseID:FBgn0030685 Length:1025 Species:Drosophila melanogaster
Sequence 2:NP_002538.1 Gene:OPHN1 / 4983 HGNCID:8148 Length:802 Species:Homo sapiens


Alignment Length:896 Identity:294/896 - (32%)
Similarity:446/896 - (49%) Gaps:144/896 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            |..||||.:|.:|||||||.|..:|:||:.|:..||.:||:...|:||.:..|:.:::.:..|..
Human     2 GHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQS 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.|:.||...||||..|.||.|.|..::..:|:||..|:..|...:|:.||:|||:|||..||.|
Human    67 FQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            |||:|..|:|....:|.|::|:||.|:.:||||..:......:.:.||.||.:||||||..||..
Human   132 KKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNI 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYME--KRTK 267
            ||.:|||:....:......|..:|...|.|.|:..:|.||.:|...||::.|||.:..|  :..|
Human   197 VEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCK 261

  Fly   268 PEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARD 332
            .....|..|||:..||.: |.||        |.||||.::|:.:..||....|      :|.|:.
Human   262 LPGQPTIEGYLYTQEKWA-LGIS--------WVKYYCQYEKETKTLTMTPMEQ------KPGAKQ 311

  Fly   333 DE-KLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGK 395
            .. .|||..|.||.:| .:||||||:...|:||.: |.|||||.:.|.|:.||||.||.|.:|  
Human   312 GPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTI-TLQALSEANRRLWMEAMDGKEPIYHSP-- 373

  Fly   396 IKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDK 460
            |...:...|:|.||.|:|:||.::|.:|::.||:||..|...::.|||....:.|...||   |.
Human   374 ITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDV---DF 435

  Fly   461 YRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQML 525
            :....:..||.|:||.|||||:||:|||:.|.:.:.|||.:.|:.|:..:|.||||||:.|.:||
Human   436 HNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREML 500

  Fly   526 DMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFK 590
            :::|.||.:|....::|.|:..|:||:|||||:|.:|::|||:::|||.|||:.|||:::.:|: 
Human   501 ELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIY- 564

  Fly   591 NKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKI-Y 654
                  :..|:.:.||.:       ||.|:.....                  .|:.::::.: .
Human   565 ------LGPPEESAAPPV-------PPPRVTARRH------------------KPITISKRLLRE 598

  Fly   655 RVVSKTNCTEPTMSSSLQNIPNGDNYALGSN------------AMNSSGGAQCISLSPPMHMLNG 707
            |.|..|:..:.:........|||   .:.|:            .:..||.......||...:|:|
Human   599 RTVFYTSSLDESEDEIQHQTPNG---TITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDG 660

  Fly   708 ILSP----TIGSINNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNF 768
            .|.|    .:|.:     :|:.:..      .|:|.|.     |.||          |:..:...
Human   661 KLEPCPEVDVGKL-----VSRLQDG------GTKITPK-----ATNG----------PMPGSGPT 699

  Fly   769 RHPEYLMTTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPN---TAMRKERFLGSASGPQ 830
            :.|.:.:....|             ...|.....:..|.|.|.||.   |.:|          |.
Human   700 KTPSFHIKRPAP-------------RPLAHHKEGDADSFSKVRPPGEKPTIIR----------PP 741

  Fly   831 QHPPVQRGLHSYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNG-LGSSIVAN 880
            ..||              .|....:|....:...|.::.|.| :.||:||:
Human   742 VRPP--------------DPPCRAATPQKPEPKPDIVAGNAGEITSSVVAS 778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GrafNP_001285296.1 BAR_RhoGAP_OPHN1-like 27..233 CDD:153286 81/205 (40%)
BAR-PH_GRAF_family 273..390 CDD:269953 50/118 (42%)
PH 279..383 CDD:278594 40/105 (38%)
RhoGAP 383..584 CDD:295372 89/200 (45%)
SH3_GRAF-like 967..1020 CDD:212815
OPHN1NP_002538.1 BAR_OPHN1 19..225 CDD:153317 81/205 (40%)
PH 266..363 CDD:278594 44/112 (39%)
BAR-PH_GRAF_family 267..370 CDD:269953 50/118 (42%)
RhoGAP_Graf 363..559 CDD:239839 89/200 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..588 5/43 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..666 12/61 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..770 24/147 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 783..802
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146196
Domainoid 1 1.000 235 1.000 Domainoid score I2368
eggNOG 1 0.900 - - E1_KOG1451
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 592 1.000 Inparanoid score I983
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45894
OrthoDB 1 1.010 - - D306399at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42036
orthoMCL 1 0.900 - - OOG6_101903
Panther 1 1.100 - - O PTHR12552
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X614
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.770

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