Protein Alignment Graf and ophn1

DIOPT Version :10

• Sequence 1: NP_996441.2
• Gene: Graf / 32522
• FlyBaseID: FBgn0030685
• Length: 1025
• Species: Drosophila melanogaster
• Sequence 2: XP_073808471.1
• Gene: ophn1 / 436982
• ZFINID: ZDB-GENE-040718-464
• Length: 789
• Species: Danio rerio
• Alignment Length: 857
• Identity: 291/857 - (33%)
• Similarity: 423/857 - (49%)
• Gaps: 142/857 - (16%)

  Fly    14 LEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLNDFNFE 78
            |||.:|..|||||||.|..:|.||:.|:..:|.:||:..::::..|..|..:::.:..|..|.|:
Zfish     6 LEFSDCYSDSPDFRERLKCYENELEKTNKFLKDVIKDGNNVINTFKEYSLAVQKFSQTLQSFQFD 70

  Fly    79 CIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENKKKFD 143
            .||...||||..|.||.:.|..::.::|:.|..::..|...:|:.||.|||:|||..||.:|||:
Zfish    71 FIGDTLTDDEMNIAESFREFAGLLQDVEEARMMLVQNASDLLIKPLEKFRKEQIGVTKERRKKFE 135

  Fly   144 KKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEFVEIL 208
            |::||:....::.:|:|:||.|..:||||..|....:.:.:.|:.||.:||:|||:.||:.||.:
Zfish   136 KESEKYYSQLDKHVNLSSKKKETQLQEADEQLDKERQAFYESSVEYVYQIQQVQEKKKFDVVEPV 200

  Fly   209 LAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTEL------KTKYMEKRTK 267
            |||:...|...:...|..:|...|.|:|:..:|.||.:||..||::.||      ..|...:..:
Zfish   201 LAFLQSILTLNNLTVEMTQDFLPYKQELQLSLQNTRNHFESTREEMEELMKRMKGSAKISIRHGQ 265

  Fly   268 PEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEA-- 330
            |.   |..|||::.||.::         ..||.|.||.:.|..:.|.|:...|        :|
Zfish   266 PA---TMEGYLYVQEKWAL---------GVTWVKNYCKYFKDNKLFIMVPMEQ--------KAGI 310

  Fly   331 -RDDEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAP 393
             :...:|||.||.||.:: .:||||||:...|: |.....||:||.:.:.||.||||.||.|.:|
Zfish   311 KQTTAQLTLKSCIRRKTDSTDKRFCFDIETSER-GSPVLLQAISEVNRKQWIEAMDGKEPIYHSP 374

  Fly   394 GKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVD 458
              |:......|::.||.|:|:||..:|.:||..||:||..|...::.|||....:.|...|  ||
Zfish   375 --IQKQAEMELNDLGFKFVRKCINFVETKGLTQEGVYRTVGSNIQVQKLLNAFFDSKCPAD--VD 435

  Fly   459 DKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQ 523
            ....| |:..||.||||.|||:|:||||||..|.:.|.|||.|.|:.|:..||.||||||:.|.:
Zfish   436 FNSSD-MDIKTITSALKFYLRSLSEPLMTYSLHGELILAAKSENLDYRLGAVHSLVYKLPERNRE 499

  Fly   524 MLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERI 588
            ||:::|.||..|.....:|.|:|.|:||:|||||:|..||:|||:|||||.|||:.|||::|.:|
Zfish   500 MLELLIKHLVSVCSHSSENLMTVSNMGVIFGPTLMRAEEETVAAMLDIKFQNIVMEILIEDYSKI 564

  Fly   589 FKNKPSADIKLP--------------DATKAPSIMY----------------------PSRSSPP 617
            ||..|...:..|              ..:|.|:.:|                      |.....|
Zfish   565 FKGPPEESVPPPVPPPRVSPRRRQPITISKRPARVYTGLQPPAFERRELNGATHNNGEPEGDGGP 629

  Fly   618 TRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKIYRVVSKTNCTEPTMSSSLQNIPNGDNYAL 682
            ....|...|..:.|..::..||.|:..|  |:.:...|::      ||.:|.....|.:|    |
Zfish   630 VPQQRTKLIPPSISPPSIPLSSPTSRRP--LHPRPAVRLL------EPEVSRFDARIQDG----L 682

  Fly   683 GSNAMNS--SGG----AQCISLSPPMHMLNGILSPTIGSINNLHTISKNETS------TR----- 730
            .|:|..:  |||    ||.......       |..|.|....|...|.:|.|      ||
Zfish   683 RSDATTNGDSGGTVNRAQSFQKRTQ-------LKGTTGEAQGLKRRSFSEKSSICRPPTRPPDPP 740

  Fly   731 ----RYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANPVTQSGSSSHIY 791
                ...|:.:..|.|                   |:|.:.|        ..|...|.||||
Zfish   741 SRLFSKPPNEDTPPSY-------------------VASKTKF--------FENASRQMGSSS--- 775

  Fly   792 TNTSSAGANSSN 803
            .|.|.|.:...|
Zfish   776 PNASPAASRDEN 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_996441.2	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	73/205 (36%)
		BAR-PH_GRAF_family	273..390	CDD:269953	43/120 (36%)
		RhoGAP	383..584	CDD:470621	99/200 (50%)
		SH3_GRAF-like	967..1020	CDD:212815
ophn1	XP_073808471.1	None