Protein Alignment Graf and Arhgap26

DIOPT Version :10

• Sequence 1: NP_996441.2
• Gene: Graf / 32522
• FlyBaseID: FBgn0030685
• Length: 1025
• Species: Drosophila melanogaster
• Sequence 2: XP_006254722.1
• Gene: Arhgap26 / 307459
• RGDID: 1310923
• Length: 814
• Species: Rattus norvegicus
• Alignment Length: 1018
• Identity: 359/1018 - (35%)
• Similarity: 507/1018 - (49%)
• Gaps: 211/1018 - (20%)

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            ||..|||.:|.:|||.|||.|..||.|||.|:..||.:||:.|.|:||.|.||:..::.|..||:
  Rat     2 GLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNE 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.|:|||.|:||||..|..||:.|..::.|:||||.:|:..|.:.:|..||.|||:|||..:|.|
  Rat    67 FKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERSRMIENASEVLITPLEKFRKEQIGAAREAK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            ||:||:|||:|.:.|:.||:|:||.|:.:||||:.:.:..:.:.:.||.||.::||||||..|||
  Rat   132 KKYDKETEKYCGTLEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEF 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKRTKPE 269
            ||.||||:.|...|||..:|.|:|..|:...|...:|.||..||..|.:|..|..|..|...:.:
  Rat   197 VEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHK 261

  Fly   270 EI--FTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARD 332
            .|  :|..|||::.||         ..|..:|.|:|||:::..::.||:.|:|.:..    :..:
  Rat   262 TISPYTMEGYLYVQEK---------RHFGTSWVKHYCTYQRDSKQITMVPFDQKSGG----KGGE 313

  Fly   333 DEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGKI 396
            ||.:||.||.||.:: .|||||||:...::|||: |.|||||:|.|.|:.||||.||.|.:....
  Rat   314 DESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVI-TMQALSEEDRRLWMEAMDGREPVYNSNKDS 377

  Fly   397 KVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDKY 461
            :......||..||..||:||..:|.||:.::|:||..||.:::.|||::.::.|.:.:...|...
  Rat   378 QSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKAASETETDICA 442

  Fly   462 RDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQMLD 526
            .  .|..|:.||||.|||.|..|||.||:...||:|||.|....||:|:|.||::||:.|.|||.
  Rat   443 E--WEIKTVTSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQETRVSEIHSLVHRLPEKNRQMLQ 505

  Fly   527 MVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFKN 591
            :::.||.:|:..:::|.|:|.|||||||||||||:||:||||:||||.||||.|||:|:|:||..
  Rat   506 LLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNT 570

  Fly   592 KPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKIYRV 656
            .|  |:.|.:|....|....|.|.||:...|                      |:.|     :..
  Rat   571 VP--DVPLTNAQLHLSRKKSSDSKPPSCSER----------------------PLTL-----FHA 606

  Fly   657 VSKTNCTE---PTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSINN 718
            |..|...|   ..::|||:::.:..|..|.|::          ||.|.|
  Rat   607 VPSTEKQEQRNSIINSSLESVSSSANSILNSSS----------SLQPNM---------------- 645

  Fly   719 LHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANPVTQ 783
                                                            ||..|.  :....|
  Rat   646 ------------------------------------------------NFSDPS--LDVVKP--- 657

  Fly   784 SGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYGQTKHY 848
                                  :..|..|||.:.....   |.|.|....|
  Rat   658 ----------------------TRPNSLPPNPSPTSPL---SPSWPMFSAP-------------- 683

  Fly   849 SPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSSLSPHL 913
            |..||||::||:.|...|::.......:.|.           ||...::.:|:.|
  Rat   684 SSPMPTSSTSSDSSPIRSVAGFVWFSVAAVV-----------LSLAWSSLHAVFS---------- 727

  Fly   914 GPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRTLYACMGES 978
                   :....:|     |         :|...:..:|....:..|.||...:.:.||||..|.
  Rat   728 -------LLVNFVP-----C---------HPNLHLLFDRPEEVVHEDSSTPFRKAKALYACKAEH 771

  Fly   979 EGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHL 1021
            :.||||....:..||..|.|||||:||||||||||||||||.|
  Rat   772 DSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_996441.2	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	101/205 (49%)
		BAR-PH_GRAF_family	273..390	CDD:269953	49/117 (42%)
		RhoGAP	383..584	CDD:470621	96/200 (48%)
		SH3_GRAF-like	967..1020	CDD:212815	32/52 (62%)
Arhgap26	XP_006254722.1	BAR_GRAF	19..225	CDD:153320	101/205 (49%)
		BAR-PH_GRAF_family	267..371	CDD:269953	49/117 (42%)
		RhoGAP_Graf	364..563	CDD:239839	96/200 (48%)
		SH3_GRAF	759..814	CDD:212997	33/54 (61%)