DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and ABR

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_016880028.1	Gene:	ABR / 29	HGNCID:	81	Length:	1137	Species:	Homo sapiens

Alignment Length:	815	Identity:	170/815 - (20%)
Similarity:	289/815 - (35%)	Gaps:	262/815 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GGGKNVR----RGLEP-------LEFEECIVDSPDFREN--LNRHE------KELDHTS------ 41
            |||..|.    .||.|       ||..:.::......|.  :|:.|      |.|..|:
Human   325 GGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPV 389

  Fly    42 ---HQIKRIIKEVKDLMSAAKILSTRMKQLAILLNDFNFECIGTAQTDDENVICESLKRFGAIIG 103
               .||:.|..:::|:....|.....:             |....|.|.:..:....::..:.:|
Human   390 LTIQQIETIFYKIQDIYEIHKEFYDNL-------------CPKVQQWDSQVTMGHLFQKLASQLG 441

  Fly   104 NIE---DEREKMLTLADKHIIESLEDFRK----KQIGGVKENK-------------KKFDKKTEK 148
            ..:   |..:..|..|:| ..:|...|:|    .::.|.|::|             |..|:.|..
Human   442 VYKAFVDNYKVALETAEK-CSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRS 505

  Fly   149 FCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESL--------------------SYVLRI 193
            .....:...:.....|:..:.:....:..:....|.|.:                    .:::.:
Human   506 TLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEV 570

  Fly   194 QEVQERIK--FEFVEILLA-------------FISGW------LVFYHTAHEQA----------- 226
            .|...:::  |.|.::||.             :...|      |||......:|
Human   571 SESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHE 635

  Fly   227 -EDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKR--------TKPEEIFTKRG--YLFL 280
             ||.:..:..|:.::||.:.|..::| .:..||.|..|..        |.|..|..:.|  ||||
Human   636 LEDMKMKISALKSEIQKEKANKGQSR-AIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFL 699

  Fly   281 M----EKS-----------------------------SILKISLLEPFKATWTK-------YY-- 303
            :    |:|                             |..|:..:.....|..|       .|
Human   700 LSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGF 764

  Fly   304 --------CTFKKQKREFTMLQFNQMNHNFTRPEAR----------DDEKLTLFSCQRRASE--- 347
                    ..||:....:..|:.:...:..::.:.|          |:|    |..:...|:
Human   765 LHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEE----FEIELEGSQSLR 825

  Fly   348 ---FEKRFCFDLTFKEKPG------------VVYTFQALSEKDHRYWISAMDGTEPTY------- 390
               :||  |:|.|...|..            :....|.:..|:....:..|:|.:..:
Human   826 ILCYEK--CYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSR 888

  Fly   391 -----LAPGK-------IKVSEAYHLDEAGFMFI-RRCIQVLEIRGLEDEGIYRKSGVGTKISKL 442
                 ..|.|       :|:|.....:.:...:| |:|::.:|.||:|:.||||.|||.|.|..|
Human   889 DMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQAL 953

  Fly   443 LALGLNQKE------SDDVFVDDK--YRDL------MESNTIASALKMYLRNLNEPLMTYQYHSD 493
            .|:....|:      :|.:..||.  .:|:      |:.|.||..||:|.|.|.|||:|.:.:..
Human   954 KAVFDASKQLQKLTRADSLAQDDPTYNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPA 1018

  Fly   494 FIE-------AAKQETLNQRVNEVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGV 551
            |:|       |||:..:      :| |:..||.||......::.||..|:.|...||||:.||..
Human  1019 FMEGIALSDPAAKENCM------MH-LLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLAT 1076

  Fly   552 VFGPTLLRPRE-ESVA---AILDIKFNNIVINILI 582
            |||||||||.| ||.|   :..||..::::..:.:
Human  1077 VFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQV 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	43/295 (15%)
		BAR-PH_GRAF_family	273..390	CDD:269953	30/196 (15%)
		PH	279..383	CDD:278594	25/181 (14%)
		RhoGAP	383..584	CDD:295372	78/245 (32%)
		SH3_GRAF-like	967..1020	CDD:212815
ABR	XP_016880028.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940