DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and rga2

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_594152.1	Gene:	rga2 / 2542682	PomBaseID:	SPAC26A3.09c	Length:	1275	Species:	Schizosaccharomyces pombe

Alignment Length:	492	Identity:	109/492 - (22%)
Similarity:	188/492 - (38%)	Gaps:	130/492 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 KFDKKTEKFCQSQERFLNM---STKKP-----ENTIQEADASLGMHEREYIQESLSYVLRIQEVQ 197
            :|..|.:....|||..|:.   |:..|     ||....||.||        ..:|:...::::..
pombe   868 RFYGKADSRPVSQEAILSQDISSSPSPVLPPSENVASYADDSL--------VSNLTMSPKLRDSM 924

  Fly   198 ERIKFEFVEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTEL----- 257
            |::..                        |:||::  ::..:|.:.  :|:.:...|.|:
pombe   925 EQVPL------------------------ENHREF--EISDRVSEL--SFDSSTGSVLEIADTRR 961

  Fly   258 KTKYMEKRTKPEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMN 322
            .....||.....||.:.|..|...::|:.::                           |..:..:
pombe   962 NQDAPEKHVPVIEIQSSRPSLEKTDQSTPVE---------------------------LLIDSHS 999

  Fly   323 HNFTRPEARDDEKLTLFSCQRRASEFEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTE 387
            .|....|.|...|...|. ..:|..:|:     ::....| |:.|...||.       |:....|
pombe  1000 QNSQNEEKRSRMKFWAFP-HHKAENYEQ-----ISDTNIP-VIETNVMLSP-------SSTTSAE 1050

  Fly   388 P----------TYLAPGKIKVSEAYHLDEAGF-MFIRRCIQVLE-IRGLEDEGIYRKSGVGTKIS 440
            |          .:..|....|:.:...:::|. :.:.|||:.|| .|..::|||||.||..:.|
pombe  1051 PLQKHIVRKSGIFGLPLNEAVNISTQFNDSGLPIVVYRCIEYLESCRAEKEEGIYRLSGSASTI- 1114

  Fly   441 KLLALGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQ 505
            |.|....|:....|:...|:..|:   :.||..||:|||||...|:....|..|.........:.
pombe  1115 KHLKEQFNEGVDYDLLSSDEEFDV---HVIAGLLKLYLRNLPTNLLDTSMHKLFELLPNVPNDSA 1176

  Fly   506 RVNEVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILD 570
            .:.|:..::.|||..||.:||.::.||..:....:.|||::.|:.:||.|||..|.:
pombe  1177 ALGELCDVISKLPPENFALLDSLLHHLRRIIAFEKVNKMNIRNVCIVFSPTLNIPSD-------- 1233

  Fly   571 IKFNNIVINILIDNYERIF----------KNKPSADI 597
                  :..:||.||:.||          :|:..:|:
pombe  1234 ------IFMMLILNYDHIFTDISRQTNGAQNESDSDV 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	19/99 (19%)
		BAR-PH_GRAF_family	273..390	CDD:269953	19/126 (15%)
		PH	279..383	CDD:278594	15/103 (15%)
		RhoGAP	383..584	CDD:295372	59/212 (28%)
		SH3_GRAF-like	967..1020	CDD:212815
rga2	NP_594152.1	PH-like	720..833	CDD:302622
		PH	722..836	CDD:278594
		RhoGAP_fBEM3	1062..1249	CDD:239865	61/204 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030