DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and ARHGAP26

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_055886.1	Gene:	ARHGAP26 / 23092	HGNCID:	17073	Length:	814	Species:	Homo sapiens

Alignment Length:	1018	Identity:	358/1018 - (35%)
Similarity:	507/1018 - (49%)	Gaps:	211/1018 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            ||..|||.:|.:|||.|||.|..||.|||.|:..||.:||:.|.|:||.|.||:..::.|..||:
Human     2 GLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNE 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.|:|||.|:||||..|..||:.|..::.|:||||.:|:..|.:.:|..||.|||:|||..||.|
Human    67 FKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            ||:||:|||:|...|:.||:|:||.|:.:||||:.:.:..:.:.:.||.||.::||||||..|||
Human   132 KKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEF 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKRTKPE 269
            ||.||||:.|...|||..:|.|:|..|:...|...:|.||..||..|.:|..|..|..|...:.:
Human   197 VEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHK 261

  Fly   270 EI--FTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARD 332
            .|  :|..|||::.||         ..|..:|.|:|||:::..::.||:.|:|.:..    :..:
Human   262 TISPYTMEGYLYVQEK---------RHFGTSWVKHYCTYQRDSKQITMVPFDQKSGG----KGGE 313

  Fly   333 DEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGKI 396
            ||.:.|.||.||.:: .|||||||:...::|||: |.|||||:|.|.|:.||||.||.|.:....
Human   314 DESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVI-TMQALSEEDRRLWMEAMDGREPVYNSNKDS 377

  Fly   397 KVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDKY 461
            :......||..||..||:||..:|.||:.::|:||..||.:::.|||::.::.|.:.:...|...
Human   378 QSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICA 442

  Fly   462 RDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQMLD 526
            .  .|..||.||||.|||.|..|||.||:...||:|||.|....||:|:|.||::||:.|.|||.
Human   443 E--WEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQ 505

  Fly   527 MVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFKN 591
            :::.||.:|:..:::|.|:|.|||||||||||||:||:||||:||||.||||.|||:|:|:||..
Human   506 LLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNT 570

  Fly   592 KPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKIYRV 656
            .|  |:.|.:|....|....|.|.||:...|                      |:.|     :..
Human   571 VP--DMPLTNAQLHLSRKKSSDSKPPSCSER----------------------PLTL-----FHT 606

  Fly   657 VSKTNCTE---PTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSINN 718
            |..|...|   ..::|||:::.:..|..|.|::          ||.|.|:..:
Human   607 VQSTEKQEQRNSIINSSLESVSSNPNSILNSSS----------SLQPNMNSSD------------ 649

  Fly   719 LHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANPVTQ 783
                                 ||..::
Human   650 ---------------------PDLAVV-------------------------------------- 655

  Fly   784 SGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYGQTKHY 848
                                :.:..|..|||.:.....   |.|.|....|
Human   656 --------------------KPTRPNSLPPNPSPTSPL---SPSWPMFSAP-------------- 683

  Fly   849 SPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSSLSPHL 913
            |..||||::||:.|...|::.......:.|.           ||...::.:|:.|
Human   684 SSPMPTSSTSSDSSPVRSVAGFVWFSVAAVV-----------LSLARSSLHAVFS---------- 727

  Fly   914 GPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRTLYACMGES 978
                   :....:|     |         :|...:..:|....:..|.||...:.:.||||..|.
Human   728 -------LLVNFVP-----C---------HPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEH 771

  Fly   979 EGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHL 1021
            :.||||....:..||..|.|||||:||||||||||||||||.|
Human   772 DSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	102/205 (50%)
		BAR-PH_GRAF_family	273..390	CDD:269953	48/117 (41%)
		PH	279..383	CDD:278594	38/104 (37%)
		RhoGAP	383..584	CDD:295372	97/200 (49%)
		SH3_GRAF-like	967..1020	CDD:212815	32/52 (62%)
ARHGAP26	NP_055886.1	BAR_GRAF	19..225	CDD:153320	102/205 (50%)
		BAR-PH_GRAF_family	267..371	CDD:269953	48/117 (41%)
		PH	267..364	CDD:278594	42/110 (38%)
		RhoGAP_Graf	364..563	CDD:239839	97/200 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..696		25/189 (13%)
		SH3_GRAF	759..814	CDD:212997	33/54 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2368
eggNOG	1	0.900	-	-		E1_KOG1451
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36349
Inparanoid	1	1.050	592	1.000	Inparanoid score	I983
Isobase	1	0.950	-	0	Normalized mean entropy	S3410
OMA	1	1.010	-	-		QHG45894
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	1	1.000	-	-		FOG0003780
OrthoInspector	1	1.000	-	-		otm42036
orthoMCL	1	0.900	-	-		OOG6_101903
Panther	1	1.100	-	-	O	PTHR12552
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820