DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and Arhgap29

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001343453.1	Gene:	Arhgap29 / 214137	MGIID:	2443818	Length:	1266	Species:	Mus musculus

Alignment Length:	1348	Identity:	239/1348 - (17%)
Similarity:	413/1348 - (30%)	Gaps:	555/1348 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KELDHTS-HQIKRIIKEV---------KDLMSAAKILSTRMKQLAILLNDFNFECIGTAQTDDEN 89
            ||:.|.. .::.|::|.:         .||.|||::|:.::|.:       ||     .:.::||
Mouse    72 KEVIHIRLDELLRVLKSILSKHQNLSSVDLQSAAEVLTAKVKAV-------NF-----TEVNEEN 124

  Fly    90 ------VICESLKRFGAIIGNI-------EDEREKMLTLADKHIIESLEDFRKKQIGGVKEN--- 138
                  .:..|::......|||       :...:.:|.|......:|.|:.....:....|.
Mouse   125 KNDIFREVFSSIETLAFTFGNILTNFLMGDVGSDSILRLPISRESKSFENISVDSVDLPHEKGNF 189

  Fly   139 ----------------------KKKFDKKTEKFCQSQERFLNMSTKKPENTIQEADA---SLGMH 178
                                  .|.:.|.|:......|:.||:..:...|.::.|:|   |:|:.
Mouse   190 SPIELDNLLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNIVKLAEATRSSIGIQ 254

  Fly   179 E-------------------------------REYIQESLSYVLRIQEVQERIK-------FEFV 205
            |                               .:::|..|.....:::.::.||       .:.:
Mouse   255 EFMPLQSLFTNALLSDIHSSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKDLWKQQQNKLL 319

  Fly   206 EILLAFISGWLV--------------FYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTE 256
            |...|.....|:              .:....||........::|..:::|.|...|||.:||.|
Mouse   320 ETETALKKAKLLCMQRQDEYEKAKSSMFRAEEEQLSSSVGLAKNLNKQLEKRRRLEEEALQKVEE 384

  Fly   257 LKTKYM-------EKRTKPEEIFTKRGY---------------------LFLMEKSSILKIS--- 290
            ....|.       |:|...|.  |||..                     ||.|::.....::
Mouse   385 ANEHYKVCVTNVEERRNDLEN--TKREILTQLRTLVFQCDLTLKAVTVNLFHMQQLQAASLANSL 447

  Fly   291 --------LLEP-------FKAT---------------------WTKYY---------------C 304
                    |.:|       .|||                     .|..|               |
Mouse   448 QSLCDSAKLYDPGQEYSEFVKATSSSELEEKVDGNVNKQMTNSPQTSGYEPADSLEDVARLPDSC 512

  Fly   305 TFKKQKR----------------EFTMLQFNQMNHNFTRPEARDDEKLTLFSCQRR--------- 344
            ...::.|                :|.|...::.....:...:.|.|.::.....|:
Mouse   513 HKLEEDRCSNSADMTGPSFVRSWKFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGT 577

  Fly   345 ---ASEFEKR-------------FCFDLTFKEKPGVVYTFQALSE----KD-------------- 375
               |.:.::|             ..|..|...|..:.:.|:.|..    :|
Mouse   578 MSSADDLDEREPPSPSEAGPNSLGAFKKTLMSKAALTHKFRKLRSPTKCRDCDGIVMFPGVECEE 642

  Fly   376 -----HRYWISAMDGTEPTYLAPGKIKVSEAYHLDEAGFMFIRR------------CIQVLEIRG 423
                 ||..:      |...:..|..|:....|:..|.|:.:.:            |...:|.|.
Mouse   643 CLLVCHRKCL------ENLVIICGHQKLQGKMHIFGAEFIQVAKKEPDGIPFVLKICASEIENRA 701

  Fly   424 LEDEGIYRKSGVGTKISKL---LALGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPL 485
            |..:||||..|...|..||   |..|::..:..:          ..|:.|...||:|||.|.||.
Mouse   702 LCLQGIYRVCGNKIKTEKLCQALENGMHLVDISE----------FSSHDICDVLKLYLRQLPEPF 756

  Fly   486 MTYQYHSDFIEAAKQETLNQRVN--------------------EVHKLVYK-------LPQPNFQ 523
            :.::.:.:||:.||:   .|.||                    ||::::.|       ||..:|.
Mouse   757 ILFRLYKEFIDLAKE---IQHVNEEQEAKKDSPEDKKHPHVSIEVNRILLKSKDLLRQLPASHFN 818

  Fly   524 MLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREE----SVAAILDIKFNNIVINILIDN 584
            .|..:|.||..|....|:|||:..||||:|||||:|||..    :::::.:......::..||..
Mouse   819 SLHYLIAHLRRVVDHAEENKMNSKNLGVIFGPTLIRPRPTTAPVTISSLAEYSNQARLVEFLITY 883

  Fly   585 YERIFKN--KPSADIKLPDATKAPSI----MYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAG 643
            .::||..  :|.|.:.......||.:    :.....||..|                  .::.:.
Mouse   884 SQKIFDGSLQPQAVVISNTGAVAPQVDQGYLPKPLLSPDER------------------DTDHSM 930

  Fly   644 NPMFLNQQKIYRVVSKTNCTEPT--MSSSLQNIPNGDNYALG-------SNAM---------NSS 690
            .|:|.:.::..|   .::|...:  :::|.:......| |||       .|.:         ::|
Mouse   931 KPLFFSSKEDIR---SSDCESKSFELTTSFEESERRQN-ALGKCDAPLLDNKVHLLFDQEHESAS 991

  Fly   691 GGAQCISLSPPMHMLNGILSPTIGSINNLHTISKNETSTRRYVPDTEIAP--------------- 740
            ...:.:..||.:.:|..               ::...|.:|:.|.|::.|
Mouse   992 QKMEDVCKSPKLLLLKS---------------NRAANSVQRHTPRTKMRPVSLPVDRLLLLASSP 1041

  Fly   741 ------DYGIIGANNGG--VTLQSHHAVPVSST-----------------------SNF------ 768
                  |.|.:.::..|  ...:..|....|:|                       :||
Mouse  1042 TERSSRDVGNVDSDKFGKNPAFEGLHRKDNSNTTRSKVNGFDQQNVQKSWDTQYVRNNFTAKTTM 1106

  Fly   769 ----RHPEYLMT--TANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSAS 827
                .:||..:|  |.|.....||.:|. ....:||..|..|   |:.|.|.||:|..|.|
Mouse  1107 IVPSAYPEKGLTVNTGNNRDHPGSKAHA-EPARAAGDVSERR---SSDSCPATAVRAPRTL---- 1163

  Fly   828 GPQQHPPVQRGLHSYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLS 892
             ..||           .|..|.|..||                                    .|
Mouse  1164 -QPQH-----------WTTFYKPPNPT------------------------------------FS 1180

  Fly   893 ARNTNDYALISSQNSSLSPHLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQI 957
            .|.|.:                        .|.|||:::            ||..:|..: ::..
Mouse  1181 VRGTEE------------------------KTALPSIAV------------PPVLVHAPQ-IHVT 1208

  Fly   958 KRDLSTGTARVRTLYACMGESEGELSFEPNQIITNVRYSHEPGWLQGT 1005
            |.|..:     ....||..::.|    :|.:      .|.||...:||
Mouse  1209 KSDPDS-----EATLACPVQTSG----QPKE------SSEEPALPEGT 1241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	46/300 (15%)
		BAR-PH_GRAF_family	273..390	CDD:269953	31/255 (12%)
		PH	279..383	CDD:278594	26/221 (12%)
		RhoGAP	383..584	CDD:295372	66/246 (27%)
		SH3_GRAF-like	967..1020	CDD:212815	9/39 (23%)
Arhgap29	NP_001343453.1	BAR	220..436	CDD:325158	36/217 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..501		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..601		5/58 (9%)
		C1	614..659	CDD:197519	6/50 (12%)
		RhoGAP	671..883	CDD:295372	62/224 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1039..1081		6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1157		14/44 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1209..1266		11/48 (23%)
		Interaction with PTPN13/PTPL1. /evidence=ECO:0000250	1263..1266
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940