DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and T04C9.1

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_741163.2	Gene:	T04C9.1 / 175849	WormBaseID:	WBGene00020209	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	1053	Identity:	344/1053 - (32%)
Similarity:	505/1053 - (47%)	Gaps:	217/1053 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLNDF 75
            |..|||.:.|.|||.||:||:.||..||.....||.|..:.|:|::..|.|||..:..|..|::|
Worm     3 LRALEFSDSISDSPWFRQNLHDHEVALDDAFKNIKLIENQCKELIACTKKLSTAQRAFAKTLSEF 67

  Fly    76 NFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIG-GVKENK 139
            .||.:||.|||||..|...||.||::|..:||||.|::..|::..:|.::.||.:.|| .:||.|
Worm    68 KFETVGTNQTDDERFIATCLKEFGSLINQVEDERMKLVGQAEESYLEPIKKFRTEAIGRTLKEEK 132

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            .|:||::.||.|:.|:.|::||.: .|..:.|||.|...::.:.|.||.||..:|.||||::|||
Worm   133 NKYDKESSKFYQTLEKHLHLSTVR-NNDFRAADAQLETQQKNFFQASLQYVAEVQSVQERMRFEF 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKRTKP- 268
            ||.|.:::..||.|:|......:|.:.:|.:::.|||||:||:.....:..|||.|.:...|||
Worm   197 VETLGSYVYSWLSFFHVGSVIHQDFKPFLDNVQTKVQKTKENYNATNAEAEELKKKLLASHTKPG 261

  Fly   269 -----EEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRP 328
                 .....|:||:::.|||.|.|....:.....||||||.:.::.|.|||:..|.......:.
Worm   262 SEDRRPTPSIKQGYVYMQEKSKIPKTIGRDVLLGRWTKYYCVYSRETRIFTMVSANSATKTDMKS 326

  Fly   329 EARDDEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLA 392
            ...........||.||..: .:||||||:..:||..|: |.|||||||...||.||||.:.....
Worm   327 AVAQTATFKFKSCSRRPMDSIDKRFCFDVCVEEKNDVM-TMQALSEKDLCEWIDAMDGAKQNSYT 390

  Fly   393 PGKIKVSEAY---HLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDD 454
            .|:......|   .||:.||.|:::||.:||..|:.::|:||..||.:|:.|::.|||:::::.:
Worm   391 AGENPSCSTYKQTQLDDIGFEFVQQCIDILEESGIHEQGVYRNCGVTSKVQKMMMLGLDRRKASE 455

  Fly   455 V----FVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVY 515
            .    ..||::    |:.||:||:|.:||||.|||||::.|:.||.|||......|::.:|..|:
Worm   456 KGGLNLRDDEW----ETKTISSAVKTFLRNLPEPLMTFELHNVFINAAKMGDATMRIDHIHFYVH 516

  Fly   516 KLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINI 580
            :||..:.:||::|:.||..|:....:|.|:|.||||.||||||||:||:||||:||||.|:|:.:
Worm   517 QLPAQHLRMLEIVVRHLKRVADLSNENLMTVSNLGVCFGPTLLRPKEETVAAIMDIKFCNVVVEV 581

  Fly   581 LIDNYERIFKNKP----------------SADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGK- 628
            ||.||::|||:||                |.|...|.||::.....||..:..:|.|:...:|.
Worm   582 LISNYDKIFKSKPKSSFGSAVPPKPDHHTSYDNGRPLATRSFGTSTPSPITSRSRSPKTPGVGSK 646

  Fly   629 -AASTGAMGSSSNTAGNPMFLNQQKIYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGG 692
             ..||..:.||.:              |.:.|.:...|:     :...:|..:.:|     ..|.
Worm   647 IVRSTQVVSSSYS--------------RGMQKRDAMYPS-----EIARHGIGFDVG-----ELGD 687

  Fly   693 AQCISLSPPMHMLNGILSPTIGSINNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSH 757
            .|..:...|:....||.....|||..:..::|.|
Worm   688 FQIENNRSPLTSPTGIAPLASGSIEEIDEVAKKE------------------------------- 721

  Fly   758 HAVPVSSTSNFRHPEYLMTTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERF 822
                                                     .|||:.::
Worm   722 -----------------------------------------RNSSDSLN---------------- 729

  Fly   823 LGSASGPQQHPPVQRGLHSYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNV 887
                           .|.|:|             |..::|....:::.:|.|.||         |
Worm   730 ---------------SLGSFG-------------SVGDESTATVVAAPDGFGKSI---------V 757

  Fly   888 AQHLSARNTNDYALISSQNSSLSPHLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNR 952
            ....|....:.|..|.:.:|.|:.                  |:||  |..:||....:......
Worm   758 KPKYSVSYASTYNRIPADSSKLTS------------------SISC--TTVDSTGVVETSFTSLT 802

  Fly   953 DVNQIKRDL---STGTA------RVRTLYACMGESEGELSFEPNQIITNVRYSHEPGWLQGTLNG 1008
            ..|.::..|   |.||.      ||:|||||..:...||||||.||||||..|:|.|||.|||||
Worm   803 RQNYLRGTLDSSSMGTTYKYLSRRVKTLYACTPDHHSELSFEPGQIITNVYESNEDGWLVGTLNG 867

  Fly  1009 KTGLIPENYVEHL 1021
            ||||||.||||.|
Worm   868 KTGLIPSNYVEPL 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	84/206 (41%)
		BAR-PH_GRAF_family	273..390	CDD:269953	46/117 (39%)
		PH	279..383	CDD:278594	39/104 (38%)
		RhoGAP	383..584	CDD:295372	88/207 (43%)
		SH3_GRAF-like	967..1020	CDD:212815	38/52 (73%)
T04C9.1	NP_741163.2	BAR_RhoGAP_OPHN1-like	19..225	CDD:153286	84/206 (41%)
		BAR-PH_GRAF_family	271..388	CDD:269953	46/117 (39%)
		RhoGAP	381..585	CDD:295372	88/207 (43%)
		SH3_GRAF-like	826..879	CDD:212815	38/52 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160592
Domainoid	1	1.000	196	1.000	Domainoid score	I1836
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36349
Inparanoid	1	1.050	543	1.000	Inparanoid score	I633
Isobase	1	0.950	-	0	Normalized mean entropy	S3410
OMA	1	1.010	-	-		QHG45894
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	1	1.000	-	-		FOG0003780
OrthoInspector	1	1.000	-	-		oto17961
orthoMCL	1	0.900	-	-		OOG6_101903
Panther	1	1.100	-	-	LDO	PTHR12552
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890