DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Graf and rga-1

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001022390.1	Gene:	rga-1 / 174751	WormBaseID:	WBGene00012203	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	267	Identity:	74/267 - (27%)
Similarity:	118/267 - (44%)	Gaps:	35/267 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 ASEFEKRFCFDLTFKEKPGVVYTFQALSE---------KDHRYWISAMDG---TEPTYLAP-GKI 396
            :|:||.:|.:.:...|..      .|||.         :||....|....   |.|....| .:.
Worm   189 SSKFENKFHYVMCIDELE------NALSVARLNLPSPIRDHDKSFSTQSNRPETPPAQPLPTQQF 247

  Fly   397 KVSEAYHLDEAGF---MFIRRCIQVLEIRGLEDEGIYRKS-GVGTKISKLLALGLNQKESDDVFV 457
            .|...:.|...|.   ..:.:.|:.||...|..||::||| .:|:  .|.|...:|:.|..|...
Worm   248 GVPLEFILSHCGGNIPPIVDQLIEYLEAHALTMEGVFRKSANIGS--IKRLQDRINKGEKIDFEN 310

  Fly   458 DDKYRDLMESNTIAS-----ALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKL 517
            |.:|:|   :..:||     .||.:.|:|.|||.|.:.:.. :.|..:.:..::...|.:.|..|
Worm   311 DPEYKD---NEYVASLHASVLLKTFFRSLGEPLTTNRLYPK-LAALSEVSKTEKSAAVKEFVKLL 371

  Fly   518 PQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILI 582
            |:.|:.:|..||..||.|:...:.|.|:..||.|||||.|..|.::.|........||....:::
Worm   372 PRENYILLKTVIKFLTRVAENSKVNLMTANNLSVVFGPNLTWPTDQEVPISQLNNLNNFCYKLIV 436

  Fly   583 DNYERIF 589
            | |:.:|
Worm   437 D-YDSVF 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286
		BAR-PH_GRAF_family	273..390	CDD:269953	13/56 (23%)
		PH	279..383	CDD:278594	11/46 (24%)
		RhoGAP	383..584	CDD:295372	60/213 (28%)
		SH3_GRAF-like	967..1020	CDD:212815
rga-1	NP_001022390.1	SEC14	74..225	CDD:214706	10/41 (24%)
rga-1	NP_001022390.1	RhoGAP	242..442	CDD:383032	60/206 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940