DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and ARHGAP42

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_689645.2	Gene:	ARHGAP42 / 143872	HGNCID:	26545	Length:	874	Species:	Homo sapiens

Alignment Length:	1020	Identity:	365/1020 - (35%)
Similarity:	513/1020 - (50%)	Gaps:	155/1020 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            ||..|||.:..:|||||||.|..||.||:.|:..||.:||:...|:.|.:.||..:::.:..|.|
Human     2 GLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQD 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.|||||.|:||||..|.:|||.|..::..:|:||.:::..|:..:|..||.|||:|||..|:.|
Human    67 FQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKDGK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            |||||::||:....|:.||:|.||.|:.:||||..:....:.:.:.||.||.:||||||:.||||
Human   132 KKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLEYVFKIQEVQEKKKFEF 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTEL--KTKYMEKRTK 267
            ||.||:|:.|...|||..:|.|::...|.|.|:..:|.||.|||..|::|..|  :.|...:..:
Human   197 VEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFESTRQEVERLMQRMKSANQDYR 261

  Fly   268 PEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFT-----MLQFNQMNHNFTR 327
            |...:|..|||::.||         .|...||.|:|||:.|..:.||     |....:||...|
Human   262 PPSQWTMEGYLYVQEK---------RPLGFTWIKHYCTYDKGSKTFTMSVSEMKSSGKMNGLVT- 316

  Fly   328 PEARDDEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYL 391
               ...|...|.||.||.:: .:||||||:...|:.|:: |.||.||.:.:.|:.||||.||.|.
Human   317 ---SSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGII-TLQAFSEANRKLWLEAMDGKEPIYT 377

  Fly   392 APGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVF 456
            .|..|...|..:|:||||.|:|:|||.:|.||:...|:||..||.:|:.||:....:.|...|:.
Human   378 LPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDID 442

  Fly   457 VDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPN 521
            :|   .:|.::.||.|.||.|||.|.||||||:.|.|||.|.|.:..|.||..||.||:|||:.|
Human   443 ID---IELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKN 504

  Fly   522 FQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYE 586
            .:|||::|.||..||...::|.|:|.||||:|||||:|.:||:|||:::|||.|||:.|||::||
Human   505 REMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYE 569

  Fly   587 RIFKNKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQ 651
            :||...|...|.||..        .|||.  :|..||.    ..|||    |....|.
Human   570 KIFHTAPDPSIPLPQP--------QSRSG--SRRTRAI----CLSTG----SRKPRGR------- 609

  Fly   652 KIYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSI 716
                   .|.|...         |:.|:|                |.||.        |..:|||
Human   610 -------YTPCLAE---------PDSDSY----------------SSSPD--------STPMGSI 634

  Fly   717 NNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANPV 781
            .:|.:.|..:.||.:   .....|     ...:||:..     :...|:||.:....|.|| :|.
Human   635 ESLSSHSSEQNSTTK---SASCQP-----REKSGGIPW-----IATPSSSNGQKSLGLWTT-SPE 685

  Fly   782 TQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYGQTK 846
            :.|...: ..|:..|...:.::..|..:||||...::||.:               ||....:..
Human   686 SSSREDA-TKTDAESDCQSVASVTSPGDVSPPIDLVKKEPY---------------GLSGLKRAS 734

  Fly   847 HYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSSLSP 911
             .|.|...|.:..|.|...|:.|...:||.....:..:.::...:..|...|.|   |.|....|
Human   735 -ASSLRSISAAEGNKSYSGSIQSLTSVGSKETPKASPNPDLPPKMCRRLRLDTA---SSNGYQRP 795

  Fly   912 HLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRTLYACMG 976
                  ..||.|.          ....|:...|              :.:|:| .:.:.:|:|..
Human   796 ------GSVVAAK----------AQLFENVGSP--------------KPVSSG-RQAKAMYSCKA 829

  Fly   977 ESEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHL 1021
            |...||||....|.:||..|.|||||:.|..|||||:|||||..|
Human   830 EHSHELSFPQGAIFSNVYPSVEPGWLKATYEGKTGLVPENYVVFL 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	92/205 (45%)
		BAR-PH_GRAF_family	273..390	CDD:269953	46/122 (38%)
		PH	279..383	CDD:278594	36/109 (33%)
		RhoGAP	383..584	CDD:295372	101/200 (51%)
		SH3_GRAF-like	967..1020	CDD:212815	27/52 (52%)
ARHGAP42	NP_689645.2	BAR_GAP10-like	19..225	CDD:153318	92/205 (45%)
		BAR-PH_GRAF_family	267..376	CDD:269953	46/122 (38%)
		RhoGAP_Graf	369..567	CDD:239839	101/200 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..720		49/224 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..777		5/27 (19%)
		SH3_GRAF3	820..874	CDD:212999	27/53 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146197
Domainoid	1	1.000	235	1.000	Domainoid score	I2368
eggNOG	1	0.900	-	-		E1_KOG1451
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	592	1.000	Inparanoid score	I983
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45894
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42036
orthoMCL	1	0.900	-	-		OOG6_101903
Panther	1	1.100	-	-	O	PTHR12552
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800