DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and Abr

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_932135.1	Gene:	Abr / 109934	MGIID:	107771	Length:	871	Species:	Mus musculus

Alignment Length:	812	Identity:	172/812 - (21%)
Similarity:	283/812 - (34%)	Gaps:	275/812 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GGGKNVR----RGLEP-------LEFEECIVDSPDFREN--LNRHE------KELDHTS------ 41
            |||.:|.    .||.|       ||..:.::......|.  :|:.|      |.|..|:
Mouse    78 GGGDSVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPV 142

  Fly    42 ---HQIKRIIKEVKDLMSAAKILSTRMKQLAILLNDFNFECIGTAQTDDENVICESLKRFGAIIG 103
               .||:.|..:::|:....|.....:             |....|.|.:..:....::..:.:|
Mouse   143 LTIQQIETIFYKIQDIYEIHKEFYDNL-------------CPKVQQWDSQVTMGHLFQKLASQLG 194

  Fly   104 NIE---DEREKMLTLADKHIIESLEDFRK----KQIGGVKENK-------------KKFDKKTEK 148
            ..:   |..:..|..|:| ..:|...|:|    .::.|.|::|             |..|:.|..
Mouse   195 VYKAFVDNYKVALETAEK-CSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRS 258

  Fly   149 FCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESL--------------------SYVLRI 193
            .....:...:.....|:..:.:....:..:....|.|.:                    .:::.:
Mouse   259 TLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEM 323

  Fly   194 QEVQERIK--FEFVEILLA-------------FISGW------LVFYHTAHEQA----------- 226
            .|...:::  |.|.::||.             :...|      |||......:|
Mouse   324 SESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHE 388

  Fly   227 -EDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKR--------TKPEEIFTKRG--YLFL 280
             ||.:..:..|:.::||.:.|..::| .:..||.|..|..        |.|..|..:.|  ||||
Mouse   389 LEDMKTKISALKSEIQKEKANKGQSR-AIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFL 452

  Fly   281 M----EKS-----------------------------SILKISLLEPFKATWTK----------- 301
            :    |:|                             |..|:..:.....|..|
Mouse   453 LSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGF 517

  Fly   302 ----------------YYCTF----------KKQKREFTMLQFNQMNHNFTRPEARDDEKLTLFS 340
                            .|||.          |.:.|.|         .:.|.|:..::.::.|..
Mouse   518 LHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVF---------RDTTEPKWDEEFEIELEG 573

  Fly   341 CQR-RASEFEKRFCFDLTFKEKPG------------VVYTFQALSEKDHRYWISAMDGTEPTY-- 390
            .|. |...:||  |:|.|...|..            :....|.:..|:....:..|:|.:..:
Mouse   574 SQSLRILCYEK--CYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVESKNWHTDVIEMNGIKVEFSM 636

  Fly   391 ----------LAPGK-------IKVSEAYHLDEAGFMFI-RRCIQVLEIRGLEDEGIYRKSGVGT 437
                      ..|.|       :|:|.....:.:...:| |:||:.:|.||:|:.||||.|||.|
Mouse   637 KFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCIEEVEKRGIEEVGIYRISGVAT 701

  Fly   438 KISKLLAL-GLNQKE-----SDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIE 496
            .|..|.|: ..|.|:     ||           |:.|.||..||:|.|.|.|||:|.:.:..|:|
Mouse   702 DIQALKAVFDANNKDILLMLSD-----------MDINAIAGTLKLYFRELPEPLLTDRLYPAFME 755

  Fly   497 -------AAKQETLNQRVNEVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFG 554
                   |||:..:      :| |:..||.||......::.||..|:.|...||||:.||..|||
Mouse   756 GIALSDPAAKENCM------MH-LLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFG 813

  Fly   555 PTLLRPRE-ESVA---AILDIKFNNIVINILI 582
            ||||||.| ||.|   :..||..::::..:.:
Mouse   814 PTLLRPSEVESKAHLTSAADIWSHDVMAQVQV 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	43/295 (15%)
		BAR-PH_GRAF_family	273..390	CDD:269953	32/201 (16%)
		PH	279..383	CDD:278594	27/186 (15%)
		RhoGAP	383..584	CDD:295372	78/237 (33%)
		SH3_GRAF-like	967..1020	CDD:212815
Abr	NP_932135.1	RhoGEF	104..294	CDD:238091	29/203 (14%)
		PH_ABR	289..472	CDD:270172	33/183 (18%)
		C2_ABR	518..638	CDD:176068	21/130 (16%)
		RhoGAP_Bcr	657..852	CDD:239852	74/207 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030