DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and arhgap42

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_002935619.1	Gene:	arhgap42 / 100493816	XenbaseID:	XB-GENE-6045446	Length:	874	Species:	Xenopus tropicalis

Alignment Length:	1050	Identity:	359/1050 - (34%)
Similarity:	509/1050 - (48%)	Gaps:	215/1050 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            ||..|||.:..:|||||||.|..||.|||.|:..||.:||:...|::|.:.||..:::.:..|.|
Frog     2 GLPTLEFSDSYLDSPDFRERLKCHEIELDRTNKFIKELIKDGNMLIAALRNLSMAVQKFSHSLQD 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.|||||.|:||||..|.:|||.|..::..:|:||.:::..|:..:|..||.|||:|||..||.|
Frog    67 FQFECIGDAETDDEINIAQSLKEFARLLITVEEERRRLIQNANDVLILPLEKFRKEQIGAAKEGK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            |||||::||:....|:.||:|:||.|:.:||||..:....:.:...||.|:.::|||||:.||||
Frog   132 KKFDKESEKYYSILEKHLNLSSKKKESLLQEADTLIDRDHQNFSDASLEYIFKVQEVQEKKKFEF 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTEL--KTKYMEKRTK 267
            ||.||||:.|...|||..:|.|.:...|.:.|:..:|.||.|||..|:::..|  :.|..::..:
Frog   197 VEPLLAFLQGLFTFYHEGYELAREFTPYKEQLQFNLQNTRNNFESTRQEMERLMQRMKPADQDYR 261

  Fly   268 PEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTML--------QFNQMNHN 324
            |...:|..|||::.||         .|...||.::|||:.|..:.|||.        :.|.:..|
Frog   262 PPSQWTMEGYLYVQEK---------RPLGFTWIRHYCTYDKGSKTFTMSVSETKSGGKVNGLISN 317

  Fly   325 FTRPEARDDEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEP 388
                   ..|...|.:|.||.:: .:||||||:...|:.|:: |.|||||.:.:.|:.||||.||
Frog   318 -------SAEMFKLKTCIRRKTDSIDKRFCFDIEVIERQGII-TLQALSEGNRKQWLEAMDGKEP 374

  Fly   389 TYLAPGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESD 453
            .|..|..|...|...|:||||.|:::||..:|.||:...|:||..||.:|:.|.:....:.|...
Frog   375 IYTLPAIISKKEEMFLNEAGFNFVKKCIHSVETRGITILGLYRIGGVNSKVQKFMNSVFSPKAPP 439

  Fly   454 DVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLP 518
            |:.:|   .||.::.||.||||.|||.|:||||||:.|.|||.|.|.:..|.||..||.||:|||
Frog   440 DMDID---LDLWDNKTITSALKNYLRCLSEPLMTYKLHKDFILAVKSDDQNYRVQAVHALVHKLP 501

  Fly   519 QPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILID 583
            |.|.:|||::|.||..||...::|.|::.||||:|||||:|.:||:|||:::|||.|||:.|||:
Frog   502 QKNREMLDILIKHLVKVSMHSQQNLMTISNLGVIFGPTLMRAQEETVAAMINIKFQNIVVEILIE 566

  Fly   584 NYERIFKNKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFL 648
            :||:||...|..:|.||.|       .|...|..||       ....|||.........
Frog   567 HYEKIFHTAPDPNIPLPQA-------QPRSISRRTR-------AICLSTGPKKPKGRYT------ 611

  Fly   649 NQQKIYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTI 713
                            |.::.     |:.|:|                |.||.        |..:
Frog   612 ----------------PCLAD-----PDSDSY----------------SSSPS--------STPM 631

  Fly   714 GSINNL--HTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVP-VSST--SNFRHPEY 773
            |||.:|  |:..:|.|:....:|..:           ..||      .:| |:||  ||.:....
Frog   632 GSIESLSSHSSEQNSTTKSLSLPQRD-----------KKGV------GIPWVTSTPSSNGQKGSS 679

  Fly   774 LMTTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRG 838
            |.|| :|.:.|...: ..|:..|...:.|:..|..|.|||....:|..:..|.....|.|.::
Frog   680 LWTT-SPESSSKEDT-TKTDVESDCQSVSSVTSPGNASPPIDLTKKSLYGLSGLKRSQAPSLR-- 740

  Fly   839 LHSYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALIS 903
                                       ||||...:|                :.:|:.:..:|.|
Frog   741 ---------------------------SLSSTEAIG----------------IKSRSPSTQSLTS 762

  Fly   904 SQNSSLSPHLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIK---------- 958
            .....: |.:.|                          |.||..|.|..|.....
Frog   763 LDLQDV-PKVHP--------------------------ELPPKIMRRRLDTGSSNGYQRPGSVVA 800

  Fly   959 ------------RDLSTGTARVRTLYACMGESEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTG 1011
                        :..||| .:.:.:|:|..|...||||....:.|||..|.|||||:.|..||||
Frog   801 AKAQLFENAGSLKQSSTG-RQAKAMYSCKAEHSHELSFPQGALFTNVYRSVEPGWLKATYEGKTG 864

  Fly  1012 LIPENYVEHL 1021
            |||||||.:|
Frog   865 LIPENYVVYL 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	93/205 (45%)
		BAR-PH_GRAF_family	273..390	CDD:269953	44/125 (35%)
		PH	279..383	CDD:278594	34/112 (30%)
		RhoGAP	383..584	CDD:295372	100/200 (50%)
		SH3_GRAF-like	967..1020	CDD:212815	28/52 (54%)
arhgap42	XP_002935619.1	BAR	19..225	CDD:386243	93/205 (45%)
		BAR-PH_GRAF_family	267..376	CDD:269953	44/125 (35%)
		RhoGAP	369..567	CDD:383032	100/200 (50%)
		HNF-1B_C	667..845	CDD:368132	47/252 (19%)
		SH3_GRAF3	820..874	CDD:212999	28/53 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2398
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1117
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49266
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.090