DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Graf and arhgap26

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_012814023.2	Gene:	arhgap26 / 100145296	XenbaseID:	XB-GENE-1011980	Length:	771	Species:	Xenopus tropicalis

Alignment Length:	1019	Identity:	338/1019 - (33%)
Similarity:	488/1019 - (47%)	Gaps:	256/1019 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            ||.||||.:|.:|||.|||.|..||.|||.|:..||.:||:.|.|::|.|.||...::.|..||:
Frog     2 GLPPLEFSDCYLDSPQFRERLKSHEIELDKTNKFIKELIKDGKSLVAAHKNLSCAKRKFAGSLNE 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.|.|||.|:||||..|..||:.|.|::||:||||.:|:..:.:.:|..||.|||:|:|..||.|
Frog    67 FKFRCIGDAETDDEICIARSLQEFAAVLGNLEDERIRMIDNSGEVLISPLEKFRKEQVGAAKEVK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            ||:||::||:|...|:.:|:|:||.|..:.|||..|....:.:.:.||.|||::.|||||..|||
Frog   132 KKYDKESEKYCAMLEKHMNLSSKKKEVLLHEADVQLDQMRQHFYEVSLEYVLKVHEVQERKMFEF 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKRTKPE 269
            ||.||||:.|...|||..:|.|:|..|:...|...:|.||:.||..|.:|..|..|..|   .|.
Frog   197 VEPLLAFLQGLFTFYHHGYELAKDFSDFKTQLSISIQNTRDRFEGTRSEVESLMKKMKE---NPH 258

  Fly   270 E-----IFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPE 329
            |     .:|..|||::.||         ..|..:|.|:|||::::.::.||:.|:|.:..    :
Frog   259 EHLALSPYTMEGYLYVQEK---------RHFGTSWVKHYCTYQRETKQMTMVPFDQKSGG----K 310

  Fly   330 ARDDEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAP 393
            ..::|.:.|.||.||.:| .|||||||:...::| .|.|.|||||:|.:.|:.||||.||.|.:.
Frog   311 VGEEEIIHLKSCIRRKTESIEKRFCFDVEGVDRP-TVLTMQALSEEDRKLWMEAMDGREPVYNSN 374

  Fly   394 GKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVD 458
            ...:......||..||..||:|||.:|.||:.::|:||..||.:::.|||...::.|.|.:  .:
Frog   375 KDSQSEGTAQLDNIGFSIIRKCIQAVETRGINEQGLYRIVGVNSRVQKLLNFLMDPKISPE--TE 437

  Fly   459 DKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQ 523
            .:.....|..||.|:||.|||.|..||||||:...||:|||.|....|:.|:|.|:::||:.|.|
Frog   438 TEIPSEWEIKTITSSLKTYLRMLPGPLMTYQFQRSFIKAAKLENQESRIKEIHCLIHRLPEKNRQ 502

  Fly   524 MLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERI 588
            ||::::.||.:|:..:::|.|:|.|||:|||||||||:||:||||:||||.|||:.|:|:|||::
Frog   503 MLNLLMTHLANVAAHHKQNLMTVANLGIVFGPTLLRPQEETVAAIMDIKFQNIVVEIIIENYEKM 567

  Fly   589 FKNKPSADIKLPDATKAPSIMYPSRS-SPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQK 652
            |..       :|:..:..|.::.||. |..::.|..|:
Frog   568 FST-------VPEMPQTNSQLHLSRKRSSDSKPPSCSE--------------------------- 598

  Fly   653 IYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSIN 717
              |.::..:.|..|.....:|..|....::.|:..|||..:.|...|               ::|
Frog   599 --RPLTLFHTTHSTEKEEKRNSVNSSAESVSSSNANSSANSTCTQCS---------------NMN 646

  Fly   718 NLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANPVT 782
            ||:...          ||.::|
Frog   647 NLNASD----------PDLDVA------------------------------------------- 658

  Fly   783 QSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYGQTKH 847
                                      ..|.||:.:                          ..|:
Frog   659 --------------------------KASRPNSLL--------------------------NPKN 671

  Fly   848 YSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSSLSPH 912
            .|.|:|:|.:.                                                   ||.
Frog   672 ISGLLPSSLNP---------------------------------------------------SPT 685

  Fly   913 LGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRTLYACMGE 977
            ..|||    ...:.||..:....|:|:|:   |..:.|                :.:.||||..|
Frog   686 SPPTC----PMFSAPSSPMPTSSTSSDSS---PVSVPR----------------KAKALYACKAE 727

  Fly   978 SEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHL 1021
            .:.||||....:..||..|.|||||:|.||||||||||||||.|
Frog   728 HDSELSFSAGTVFDNVYPSQEPGWLEGILNGKTGLIPENYVEFL 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	99/205 (48%)
		BAR-PH_GRAF_family	273..390	CDD:269953	46/117 (39%)
		PH	279..383	CDD:278594	36/104 (35%)
		RhoGAP	383..584	CDD:295372	93/200 (47%)
		SH3_GRAF-like	967..1020	CDD:212815	31/52 (60%)
arhgap26	XP_012814023.2	BAR_GRAF	19..225	CDD:153320	99/205 (48%)
		BAR-PH_GRAF_family	267..371	CDD:269953	46/117 (39%)
		RhoGAP_Graf	364..563	CDD:239839	93/200 (47%)
		SH3_GRAF	716..771	CDD:212997	33/70 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2398
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36349
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1117
OMA	1	1.010	-	-		QHG45894
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	1	1.000	-	-		FOG0003780
OrthoInspector	1	1.000	-	-		otm49266
Panther	1	1.100	-	-	O	PTHR12552
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110