DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Graf and arhgap10

DIOPT Version :9

Sequence 1:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_002933548.2	Gene:	arhgap10 / 100145146	XenbaseID:	XB-GENE-921747	Length:	788	Species:	Xenopus tropicalis

Alignment Length:	1021	Identity:	340/1021 - (33%)
Similarity:	492/1021 - (48%)	Gaps:	243/1021 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74
            ||:||||.:|.:|||..||.:..||.|||.|:..||.::|:.|:|::|.|.||...::.|..|.|
Frog     2 GLQPLEFSDCYLDSPWLRERIRAHEAELDRTNRFIKDLLKDGKNLIAATKSLSNAQRKFANSLRD 66

  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139
            |.||.||.|:||||..|..||:.|...:.|:|::||.|....::.:|:.||.|||:|:|.|||.|
Frog    67 FKFEFIGDAETDDERCIDASLQEFSTFLQNLEEQREIMALNVNETLIKPLERFRKEQLGAVKELK 131

  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204
            |||||.|||.....::.|::|.||.|..:||||..:..:.:.:.|.||.||.::||:|||.||||
Frog   132 KKFDKDTEKNYSLLDKHLSLSAKKKEPQLQEADVQVDQNRQHFYQLSLEYVCKLQEIQERKKFEF 196

  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTEL-----KTKYMEK 264
            ||.:|.|..|...|||..:|.|:|...|..||:..:|.||..|:..|.:|.||     |.....|
Frog   197 VEPMLLFFQGIFTFYHQGYELAKDFSHYKLDLQINIQNTRNRFDGTRSEVEELLRKIRKNPQEHK 261

  Fly   265 RTKPEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPE 329
            |..|   ||..|||::.||..       .||.::|.|:||.:||..:.|||..:...:..    :
Frog   262 RVSP---FTMEGYLYVQEKRP-------APFGSSWVKHYCMYKKDSKSFTMFPYEHRSGG----K 312

  Fly   330 ARDDEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAP 393
            ..:.:..:|.||.:|.:: .::|||||:...|:|||:.|.|:.||.|...|:..:||.|..:|:.
Frog   313 IGEGDSFSLKSCTKRHTDTIDRRFCFDIEASERPGVLTTMQSFSEDDRCLWMEVLDGKESRFLSL 377

  Fly   394 GKIKVSE---AYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDV 455
            .: .||.   ...||:.||..::.||:.:|.||:.|:|:||..||.:|:.:||:|.::.|...||
Frog   378 NR-SVSRPEGGARLDKYGFAIVKNCIRAIETRGINDQGLYRVVGVSSKVQRLLSLLMDVKTCCDV 441

  Fly   456 FVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQP 520
            .:|..  :..|..|:.||||:|||:|.||||||:.|..||...|..:...|||.:|.|::|||:.
Frog   442 DLDSS--EEWEVKTVTSALKLYLRSLPEPLMTYELHDQFINPTKSGSPESRVNSIHHLIHKLPEK 504

  Fly   521 NFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNY 585
            |.:|||::|.||.:|:...:||.|:|.||||||||||:||:||:||||:|:||.|||:.|||:|:
Frog   505 NREMLDILITHLANVAHHAKKNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENH 569

  Fly   586 ERIFKNKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQ 650
            |:||||.||.   |...:.:.||      |||...||.|:..:.              .|:
Frog   570 EKIFKNPPSG---LEAESDSSSI------SPPNAPPRQSRRHRK--------------RPV---- 607

  Fly   651 QKIYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGS 715
             .:|.:..:.:.|:..::.. ::.|.|..                .||||..      |:||
Frog   608 -PVYDLSLELDNTDMNLTPR-EDTPTGST----------------DSLSPQS------LTPT--- 645

  Fly   716 INNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANP 780
              ..||   |.|:..|           ..|.|:.||:       |..|::.|..|        :|
Frog   646 --TPHT---NATADER-----------NHIMASIGGL-------VDWSASENLIH--------SP 679

  Fly   781 VTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYGQT 845
            :..       :.|..|..|::   :..|..:.|              .|.|..|.:.
Frog   680 LVS-------WINDESPAAST---VPTSQAAEP--------------APVQQDPEEE-------- 712

  Fly   846 KHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSSLS 910

Frog   713 ----------------------------------------------------------------- 712

  Fly   911 PHLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRTLYACM 975
                         .|||:.||:....|:|                      |:...:.:.:|.|.
Frog   713 -------------LTLPAHSLTTSDKAAE----------------------SSAKKKAKAVYPCE 742

  Fly   976 GESEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHL 1021
            .|...|||||...:..:|.||.|||||:|||||:.||||||||:.|
Frog   743 AEHSSELSFEVGAVFEDVHYSREPGWLEGTLNGRRGLIPENYVQFL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	93/205 (45%)
		BAR-PH_GRAF_family	273..390	CDD:269953	39/117 (33%)
		PH	279..383	CDD:278594	32/104 (31%)
		RhoGAP	383..584	CDD:295372	96/203 (47%)
		SH3_GRAF-like	967..1020	CDD:212815	29/52 (56%)
arhgap10	XP_002933548.2	BAR_GRAF2	19..225	CDD:153319	93/205 (45%)
		BAR-PH_GRAF_family	267..371	CDD:269953	38/114 (33%)
		RhoGAP_Graf	367..568	CDD:239839	96/203 (47%)
		SH3_GRAF2	734..787	CDD:212998	29/52 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2398
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1117
OMA	1	1.010	-	-		QHG45894
OrthoDB	1	1.010	-	-		D306399at33208
OrthoFinder	1	1.000	-	-		FOG0003780
OrthoInspector	1	1.000	-	-		otm49266
Panther	1	1.100	-	-	LDO	PTHR12552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080