Protein Alignment CG8260 and KLHL28

DIOPT Version :10

• Sequence 1: NP_573069.1
• Gene: CG8260 / 32521
• FlyBaseID: FBgn0030684
• Length: 415
• Species: Drosophila melanogaster
• Sequence 2: NP_001295041.1
• Gene: KLHL28 / 54813
• HGNCID: 19741
• Length: 585
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 59/265 - (22%)
• Similarity: 104/265 - (39%)
• Gaps: 48/265 - (18%)

  Fly    73 IVEIDHEVPP----------EEYLVPYI----QNYECADIIVTVHDRVFLCHNIIL---SIYSRR 120
            :.::||..|.          .|.|:..:    |::|..|||:.|.|.....|.::|   |.|.:.
Human    12 LYQMDHTSPTYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKA 76

  Fly   121 ML--KILQEDVDHIVFKSNDLSPKGFSDAYLW----MISSDGEVNPCDMGEILRAAYFLDIPELL 179
            |.  .:.:::...:.|:..|.:.......|.:    .||.|      .:..:|.||..|.|..:|
Human    77 MFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQD------TVESLLPAANLLQIKLVL 135

  Fly   180 EACWA----NLDRITFFEISAFRLLFELRGATNLWDVFDKLTGRISISILPVASTREFLCLSETQ 240
            :.|.|    .||......||.|...:..|      |::...|..|..:...|..|.||..|:...
Human   136 KECCAFLESQLDPGNCIGISRFAETYGCR------DLYLAATKYICQNFEAVCQTEEFFELTHAD 194

  Fly   241 ICYILKSNFLAINSEMEA-----SSISIRRSSTYRVLSQIRFSFLPPLMLKKFRSEELHKMPEFS 300
            :..|:.::.|.:.:|...     |.|........:.|:|:..|...||:..||    |.::.|.:
Human   195 LDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKF----LTRLYEAN 255

  Fly   301 DILKE 305
            .::::
Human   256 HLIRD 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8260	NP_573069.1	BTB_POZ	97..186	CDD:453885	24/101 (24%)
		BACK	200..287	CDD:197943	19/91 (21%)
		DUF4734	305..387	CDD:434992	0/1 (0%)
KLHL28	NP_001295041.1	PHA03098	49..567	CDD:222983	52/228 (23%)
		KELCH repeat	335..386	CDD:276965
		KELCH repeat	390..433	CDD:276965
		KELCH repeat	437..479	CDD:276965
		KELCH repeat	483..527	CDD:276965
		KELCH repeat	530..573	CDD:276965