DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8260 and Keap1

DIOPT Version :10

Sequence 1:NP_573069.1 Gene:CG8260 / 32521 FlyBaseID:FBgn0030684 Length:415 Species:Drosophila melanogaster
Sequence 2:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster


Alignment Length:436 Identity:87/436 - (19%)
Similarity:146/436 - (33%) Gaps:114/436 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 FANSIRTLKE-DPTESEIVEIDHEVPPEEYLVPYIQNYE--CADIIVTVHDRVFLCHNIILSI-- 116
            |.::..||.: |.|:.::.........|...:.|:....  ..|:::.|...:|..|.::||.  
  Fly    48 FGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAAS 112

  Fly   117 -YSRRMLK--ILQEDVDHIVFKSNDLSPKGFSDAYLWMISSDGEVNPCDMGEILRAAYFLDIPEL 178
             |.:.|..  :.:.::..:..:.  :.|...|....:|.:....|....:.::|.||....:|.:
  Fly   113 PYFKAMFTGGLKESEMSRVQLQG--VCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNV 175

  Fly   179 LEACWA----NLDRITFFEISAFRLLFELRGATNLW---DVFDKLTGRISISILPVASTREFLCL 236
            ::||.|    .||......|:.|.   |..|...|.   :||      |..:...|....|||.|
  Fly   176 IDACCAFLERQLDPTNAIGIAHFA---EQHGCVELQKKANVF------IERNFTQVCQEEEFLQL 231

  Fly   237 SETQICYILKSNFLAINSEMEASSISI---------RRSSTYRVLSQIRFSFLPPLMLKK----- 287
            |..|:..:::.:.|.:..|.|..:..:         |......:|..:|..||.|..||:     
  Fly   232 SAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNC 296

  Fly   288 ----------------FRSEELHKMPEFS---------------------DILKEFSKSPDVITL 315
                            |:...|||.|...                     |||:.::......|.
  Fly   297 DVLRKVPACREYLAKIFKDLTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTT 361

  Fly   316 LRD---------SVFNSSLLLTV--RNN-------PSVLDTHVEFTE-----VELMEPRHWVQDH 357
            |.:         :.|.......|  |||       ...:|.:...||     ..:..|||.|...
  Fly   362 LANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVA 426

  Fly   358 TCD-------------YHRKVTQLCPNMRFITLNEYQEYLKRLSIG 390
            ..|             ||..|....|::...||.: ..:.|||.:|
  Fly   427 VMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQ-PMHAKRLGVG 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8260NP_573069.1 BTB_POZ 97..186 CDD:453885 19/97 (20%)
BACK 200..287 CDD:197943 23/98 (23%)
DUF4734 305..387 CDD:434992 22/117 (19%)
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 79/392 (20%)
KELCH repeat 369..416 CDD:276965 8/46 (17%)
KELCH repeat 420..463 CDD:276965 10/43 (23%)
KELCH repeat 467..510 CDD:276965 3/5 (60%)
KELCH repeat 514..558 CDD:276965
KELCH repeat 561..606 CDD:276965
Blue background indicates that the domain is not in the aligned region.

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