DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8260 and KLHL41

DIOPT Version :10

Sequence 1:NP_573069.1 Gene:CG8260 / 32521 FlyBaseID:FBgn0030684 Length:415 Species:Drosophila melanogaster
Sequence 2:NP_006054.2 Gene:KLHL41 / 10324 HGNCID:16905 Length:606 Species:Homo sapiens


Alignment Length:659 Identity:144/659 - (21%)
Similarity:232/659 - (35%) Gaps:189/659 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   297 RKSSRWDVTEEDLKRKLSATSSTHNPRERASVELETRQSEEIQKLQRLVNVIKPRDDSLEGTSNL 361
            |||.|.|...|::|......:.......:...|||.....:::..::.|.::             
Human     2 RKSPRRDCRHENVKCTKQTRALKRGDASKRQAELEAAIQRKVEFERKAVRIV------------- 53

  Fly   362 DAANREIPIEASSTAPLLSRSFQFWRERSKSPDDSAQNHSDLHGTSLKSRPDAQK--NPIPQAVA 424
                 |..:|.:.|...|.....|......|  |.....|.:   .|...|..||  ..||:.  
Human    54 -----EQLLEENITEEFLKECGMFITPAHYS--DVVDERSII---KLCGYPLCQKKLGVIPKQ-- 106

  Fly   425 KTMLKFPVSTLDRPV---NTKKSMAFG--------QEAQIMPKSSVFVNNAVKIPQKFVIVKEAS 478
                |:.:||....|   ..:||....        .|.|| ||:.|:|....: |..|.::|:..
Human   107 ----KYRISTKTNKVYDITERKSFCSNFCYRASKFFETQI-PKTPVWVREEER-PPDFQLLKKGQ 165

  Fly   479 SDNPNAAENPVSTQNTVDLHDIPSKTPQQKVTSENRGSGAPNSSEDQQKLDEIAPTTQILPEDPV 543
            |.  ::.|.....::.|...|:.             ||||..:.                 .||.
Human   166 SG--SSGEVVQFFRDAVTAADVD-------------GSGALEAQ-----------------CDPA 198

  Fly   544 SVQSRSDVCEVTAETSQKSVGPERIGGDAQSSSENTVSVRNR---VDLHGIPSKTPQKLVQSGKS 605
            |..|.|                ||...:.:....:::...||   ||..  |....:..:...|:
Human   199 SSSSWS----------------ERASDEEEQGFVSSLLPGNRPKAVDTR--PQPHTKSSIMRKKA 245

  Fly   606 AQS--STENQQQI----EMTPEARILSKNPISAQSKTPVKEERPESHS---LSESF---ASTQHP 658
            ||:  |.|.:|.:    |.....|:.|:..: |..|.|:|:|..:..|   |.:.|   |.::|.
Human   246 AQNVDSKEGEQTVSEVTEQLDNCRLDSQEKV-ATCKRPLKKESTQISSPGPLCDRFNTSAISEHK 309

  Fly   659 MKISE-----ISENSTQ---------NRSDSSRIGLRSVKLE-------QIPSRTI---KVEEPT 699
            ..:|:     ||:.|.:         |....|..||..|:.|       ::.|.|:   |.||..
Human   310 HGVSQVTLVGISKKSAEHFRSKFAKSNPGSGSASGLVHVRPEVAKANLLRVLSDTLTEWKTEETL 374

  Fly   700 DFPSNSEPEAQIPLETRTLEPSEASSVQPEPPIDQEEAENDENPEILTPNS--PTIDQDEAQNS- 761
            .|......::.      .|:||.||  :|:..:|:::...|       |.|  |.:.|  |||: 
Human   375 KFLYGQNHDSV------CLKPSSAS--EPDEELDEDDISCD-------PGSCGPALSQ--AQNTL 422

  Fly   762 DA--PDASADSDLPKLEPELERMIDFLVEITEKISVPAIKTDIWKLYQAR-------MKQNVKEE 817
            ||  |...:|:.:..| |..|.    |.:.||.:::     .:.:.|:.|       .|....:|
Human   423 DATLPFRGSDTAIKPL-PSYES----LKKETEMLNL-----RVREFYRGRCVLNEDTTKSQDSKE 477

  Fly   818 CIRQRFMSKLAPIIHRLDNYSIEARVRIIFVLSVKVDADFLKELR----------KNAV--VRVD 870
            .:.||..|  .|:|.......|  |.||:.....||....|..|:          ||.:  .|:.
Human   478 SVLQRDPS--FPLIDSSSQNQI--RRRIVLEKLSKVLPGLLGPLQITMGDIYTELKNLIQTFRLS 538

  Fly   871 DEQLITKYV 879
            :..:|.|.|
Human   539 NRNIIHKPV 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8260NP_573069.1 BTB_POZ 97..186 CDD:453885
BACK 200..287 CDD:197943
DUF4734 305..387 CDD:434992 11/81 (14%)
KLHL41NP_006054.2 BTB_POZ_KLHL41_KBTBD10 6..135 CDD:349650 28/157 (18%)
PHA03098 39..578 CDD:222983 134/622 (22%)
KELCH repeat 335..384 CDD:276965 12/48 (25%)
Kelch 1 346..398 14/59 (24%)
KELCH repeat 388..433 CDD:276965 17/55 (31%)
Kelch 2 399..447 17/61 (28%)
KELCH repeat 437..482 CDD:276965 10/54 (19%)
Kelch 3 448..495 11/53 (21%)
KELCH repeat 485..530 CDD:276965 11/48 (23%)
Kelch 4 497..542 11/46 (24%)
Kelch 5 544..599 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

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