DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvd and MVD1

DIOPT Version :9

Sequence 1:	NP_001285295.1	Gene:	Mvd / 32520	FlyBaseID:	FBgn0030683	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_014441.1	Gene:	MVD1 / 855779	SGDID:	S000005326	Length:	396	Species:	Saccharomyces cerevisiae

Alignment Length:	410	Identity:	183/410 - (44%)
Similarity:	248/410 - (60%)	Gaps:	42/410 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSVTCVAPVNIALIKYWGKRHEELILPVNDSISMTLSTDELCAKTTVTASESFETNRMWLNGEE 65
            :::.:..||||||.:||||||..:|.||.|.|||:|||.|:|...|:...:..||.:.:|||||
Yeast     3 VYTASVTAPVNIATLKYWGKRDTKLNLPTNSSISVTLSQDDLRTLTSAATAPEFERDTLWLNGE- 66

  Fly    66 VPFE-ESSRLQRCLNEVHRLAVASGSQKVP-PT---WKLHIASVNNFPTAAGLASSAAGYACLVY 125
             |.. ::.|.|.||.::.:|.....|:... ||   |||||.|.|||||||||||||||:|.||.
Yeast    67 -PHSIDNERTQNCLRDLRQLRKEMESKDASLPTLSQWKLHIVSENNFPTAAGLASSAAGFAALVS 130

  Fly   126 SLSRLYDIPLN-EELTTVARQGSGSACRSLYGGFVQWHRGALDDGSDSVARQIAPSDHWPNMHVL 189
            ::::||.:|.: .|::.:||:|||||||||:||:|.|..|..:||.||:|.|||.|..||.|...
Yeast   131 AIAKLYQLPQSTSEISRIARKGSGSACRSLFGGYVAWEMGKAEDGHDSMAVQIADSSDWPQMKAC 195

  Fly   190 ILVVNDARKKTASTRGMQQAVKTSQLIKHRVDQVVPDRIIRLREAIASHDFQAFAEITMKDSNQF 254
            :|||:|.:|..:||:|||..|.||:|.|.|::.|||.|...:|:||...||..||:.||.|||.|
Yeast   196 VLVVSDIKKDVSSTQGMQLTVATSELFKERIEHVVPKRFEVMRKAIVEKDFATFAKETMMDSNSF 260

  Fly   255 HAIALDTYPPCVYMNDVSHSIVSFVHDYNERMGSYHAAYTFDAGPNACLYVLAEHVPHLLSAIQK 319
            ||..||::||..||||.|..|:|:.|..|:..|....||||||||||.||.|||:...|.:.|.|
Yeast   261 HATCLDSFPPIFYMNDTSKRIISWCHTINQFYGETIVAYTFDAGPNAVLYYLAENESKLFAFIYK 325

  Fly   320 VFPNDLADGGTYLRGLPIP--------KVQDAESSKLDS-------LDVHAKNAFRYIIHTKVGE 369
            :|.:             :|        :..:|.:.:.:|       ||:..:.....:|.|:||.
Yeast   326 LFGS-------------VPGWDKKFTTEQLEAFNHQFESSNFTARELDLELQKDVARVILTQVGS 377

  Fly   370 GPKELSADNSLLIN---GLP 386
            ||:|   .|..||:   |||
Yeast   378 GPQE---TNESLIDAKTGLP 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvd	NP_001285295.1	PLN02407	1..322	CDD:178029	164/326 (50%)
Mvd	NP_001285295.1	GHMP_kinases_C	231..323	CDD:285715	48/91 (53%)
MVD1	NP_014441.1	mevDPdecarb	6..328	CDD:130307	164/323 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343323
Domainoid	1	1.000	138	1.000	Domainoid score	I1053
eggNOG	1	0.900	-	-		E1_COG3407
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1843
Inparanoid	1	1.050	320	1.000	Inparanoid score	I450
Isobase	1	0.950	-	0	Normalized mean entropy	S814
OMA	1	1.010	-	-		QHG62270
OrthoFinder	1	1.000	-	-		FOG0004204
OrthoInspector	1	1.000	-	-		oto99775
orthoMCL	1	0.900	-	-		OOG6_102327
Panther	1	1.100	-	-	LDO	PTHR10977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R783
SonicParanoid	1	1.000	-	-		X2949
TreeFam	1	0.960	-	-
	16	15.740