DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvd and Mvd

DIOPT Version :9

Sequence 1:	NP_001285295.1	Gene:	Mvd / 32520	FlyBaseID:	FBgn0030683	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_112324.2	Gene:	Mvd / 81726	RGDID:	621292	Length:	401	Species:	Rattus norvegicus

Alignment Length:	391	Identity:	198/391 - (50%)
Similarity:	258/391 - (65%)	Gaps:	12/391 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VTCVAPVNIALIKYWGKRHEELILPVNDSISMTLSTDELCAKTTVTASESFETNRMWLNGEEVPF 68
            |||.||||||:|||||||.|.||||:|.|:|:||..|:|...||...|:.|..:|:||||.|...
  Rat    11 VTCTAPVNIAVIKYWGKRDEALILPINSSLSVTLHQDQLKTTTTAAISKDFTEDRIWLNGREEDV 75

  Fly    69 EESSRLQRCLNEVHRLA---VASGSQKVPPT---WKLHIASVNNFPTAAGLASSAAGYACLVYSL 127
            .: .|||.||.|:.|||   .::|.....|.   :|:|:||||||||||||||||||||||.|:|
  Rat    76 GQ-PRLQACLREIRRLARKRRSTGDGDALPLSLGYKVHVASVNNFPTAAGLASSAAGYACLAYTL 139

  Fly   128 SRLYDIPLNEELTTVARQGSGSACRSLYGGFVQWHRGALDDGSDSVARQIAPSDHWPNMHVLILV 192
            :|:|.:  ..:|:.|||:||||||||||||||:|..|...||.||:||||||..|||.:.|||||
  Rat   140 ARVYGV--EGDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQIAPEWHWPQLRVLILV 202

  Fly   193 VNDARKKTASTRGMQQAVKTSQLIKHRVDQVVPDRIIRLREAIASHDFQAFAEITMKDSNQFHAI 257
            |:..:|.|.||.|||.:|.||.|:|.|.:.:||:|:..:...|...||||||::||||||||||.
  Rat   203 VSAEKKPTGSTVGMQTSVATSTLLKFRAESIVPERMKEMTRCIQEQDFQAFAQLTMKDSNQFHAT 267

  Fly   258 ALDTYPPCVYMNDVSHSIVSFVHDYNERMGSYHAAYTFDAGPNACLYVLAEHVPHLLSAIQKVFP 322
            .|||:||..|:||.|..|:..||.:|...|....||||||||||.::.|.:.|...::|::..||
  Rat   268 CLDTFPPISYLNDTSRRIIQLVHRFNAHHGQTKVAYTFDAGPNAVIFTLEDTVAEFVAAVRHSFP 332

  Fly   323 NDLADGGTYLRGLPIPKVQDAESSKLDSLDVHAKNAFRYIIHTKVGEGPKELSADNSLLI--NGL 385
             ..|:|..:|:||.:..|..::..|.......:....:|||.|:||.||:.|...:..|:  :||
  Rat   333 -PAANGDKFLKGLQVAPVLLSDELKTSLATEPSPGGVQYIIATQVGPGPQVLDDPHHHLLGPDGL 396

  Fly   386 P 386
            |
  Rat   397 P 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvd	NP_001285295.1	PLN02407	1..322	CDD:178029	176/323 (54%)
Mvd	NP_001285295.1	GHMP_kinases_C	231..323	CDD:285715	45/91 (49%)
Mvd	NP_112324.2	MVD1	9..338	CDD:421578	180/332 (54%)
		(R)-5-diphosphomevalonate binding. /evidence=ECO:0000250\|UniProtKB:O23722	24..27		2/2 (100%)
		(R)-5-diphosphomevalonate binding. /evidence=ECO:0000250\|UniProtKB:O23722	157..162		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..401		4/14 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339566
Domainoid	1	1.000	162	1.000	Domainoid score	I3902
eggNOG	1	0.900	-	-		E1_COG3407
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1843
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2047
OMA	1	1.010	-	-		QHG62270
OrthoDB	1	1.010	-	-		D1065019at2759
OrthoFinder	1	1.000	-	-		FOG0004204
OrthoInspector	1	1.000	-	-		oto97453
orthoMCL	1	0.900	-	-		OOG6_102327
Panther	1	1.100	-	-	LDO	PTHR10977
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2949
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770