DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mvd and mvda

DIOPT Version :9

Sequence 1:	NP_001285295.1	Gene:	Mvd / 32520	FlyBaseID:	FBgn0030683	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001007423.1	Gene:	mvda / 492781	ZFINID:	ZDB-GENE-041114-127	Length:	400	Species:	Danio rerio

Alignment Length:	393	Identity:	204/393 - (51%)
Similarity:	261/393 - (66%)	Gaps:	15/393 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VTCVAPVNIALIKYWGKRHEELILPVNDSISMTLSTDELCAKTTVTASESFETNRMWLNGEEVPF 68
            |||.||||||:|||||||.|:||||||.|:|:||..|.|...||:..|.||..:.:||||:|...
Zfish    12 VTCTAPVNIAVIKYWGKRDEDLILPVNASLSVTLHQDHLRTTTTIACSRSFHKDCIWLNGKEQDI 76

  Fly    69 EESSRLQRCLNEVHRLAVA---SGSQKVPPTWKLHIASVNNFPTAAGLASSAAGYACLVYSLSRL 130
            .. .|||.||.|:.|||..   :|......:.|:||.|||||||||||||||||||||||:||:|
Zfish    77 SH-PRLQSCLLEIRRLAQRRKNTGDPASDVSNKVHICSVNNFPTAAGLASSAAGYACLVYTLSQL 140

  Fly   131 YDIPLNEELTTVARQGSGSACRSLYGGFVQWHRGALDDGSDSVARQIAPSDHWPNMHVLILVVND 195
            :::  ..||:.||||||||||||||||||||..|...||.||:|.|:|...:||.:.||||||:.
Zfish   141 FNV--EGELSGVARQGSGSACRSLYGGFVQWKLGEQSDGKDSIAEQVASELYWPELRVLILVVSA 203

  Fly   196 ARKKTASTRGMQQAVKTSQLIKHRVDQVVPDRIIRLREAIASHDFQAFAEITMKDSNQFHAIALD 260
            .:|...||.||..:|:||.|:|:|.|.|||.|:..:..||...||..|.|:|||||||||||.||
Zfish   204 EQKSVGSTSGMHTSVETSHLLKYRADAVVPGRMEEMIRAIRLRDFPKFGELTMKDSNQFHAICLD 268

  Fly   261 TYPPCVYMNDVSHSIVSFVHDYNERMGSYHAAYTFDAGPNACLYVLAEHVPHLLSAIQKVFPNDL 325
            ||||..|:|::||.|:|.||.||:..|....||||||||||.:|.|.:::|..:..::..||.::
Zfish   269 TYPPIFYLNNISHQIISLVHRYNQYYGETRVAYTFDAGPNAVIYSLQDYLPEFVEVVRHFFPPEV 333

  Fly   326 ADGGTYLRGLPIPKVQDAESSKLDSLDVHAK---NAFRYIIHTKVGEGPKELSADNSLLI--NGL 385
            .: ..:.:|||   |..|:.|:....|::.|   |..||:|.||.|.||:.:...|..|:  :||
Zfish   334 NE-EEFFKGLP---VCPADLSEEMIRDINMKPTPNGIRYMISTKAGPGPRVVEDPNLHLLGADGL 394

  Fly   386 PLK 388
            |.|
Zfish   395 PKK 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvd	NP_001285295.1	PLN02407	1..322	CDD:178029	179/320 (56%)
Mvd	NP_001285295.1	GHMP_kinases_C	231..323	CDD:285715	48/91 (53%)
mvda	NP_001007423.1	PLN02407	11..332	CDD:178029	181/322 (56%)
		(R)-5-diphosphomevalonate binding. /evidence=ECO:0000250\|UniProtKB:O23722	25..28		2/2 (100%)
		(R)-5-diphosphomevalonate binding. /evidence=ECO:0000250\|UniProtKB:O23722	155..160		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579329
Domainoid	1	1.000	170	1.000	Domainoid score	I3750
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1843
Inparanoid	1	1.050	378	1.000	Inparanoid score	I2039
OMA	1	1.010	-	-		QHG62270
OrthoDB	1	1.010	-	-		D1065019at2759
OrthoFinder	1	1.000	-	-		FOG0004204
OrthoInspector	1	1.000	-	-		oto39764
orthoMCL	1	0.900	-	-		OOG6_102327
Panther	1	1.100	-	-	LDO	PTHR10977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R783
SonicParanoid	1	1.000	-	-		X2949
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940