DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvd and MVD

DIOPT Version :9

Sequence 1:	NP_001285295.1	Gene:	Mvd / 32520	FlyBaseID:	FBgn0030683	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	XP_011521388.1	Gene:	MVD / 4597	HGNCID:	7529	Length:	434	Species:	Homo sapiens

Alignment Length:	427	Identity:	193/427 - (45%)
Similarity:	260/427 - (60%)	Gaps:	48/427 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SVTCVAPVNIALIKYWGKRHEELILPVNDSISMTLSTDELCAKTTVTASESFETNRMWLNGEEVP 67
            :|||.||||||:|||||||.|||:||:|.|:|:||..|:|...||...|:.|..:|:||||.|..
Human     9 AVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDFTEDRIWLNGREED 73

  Fly    68 FEESSRLQRCLNEVHRLAVASGSQK----VPP--TWKLHIASVNNFPTAAGLASSAAGYACLV-- 124
            ..: .|||.||.|:..||....:.:    :|.  :.|:|:|||||||||||||||||||||||
Human    74 VGQ-PRLQACLREIRCLARKRRNSRDGDPLPSSLSCKVHVASVNNFPTAAGLASSAAGYACLVAA 137

  Fly   125 --------------------------------YSLSRLYDIPLNEELTTVARQGSGSACRSLYGG 157
                                            |:|:|:|.:  ..:|:.|||:||||||||||||
Human   138 GVGLSPVIPVLKRLMGEKHCRPGVQDQPGQHTYTLARVYGV--ESDLSEVARRGSGSACRSLYGG 200

  Fly   158 FVQWHRGALDDGSDSVARQIAPSDHWPNMHVLILVVNDARKKTASTRGMQQAVKTSQLIKHRVDQ 222
            ||:|..|...||.||:|||:||..|||.:.||||||:..:|.|.||.||:.:|:||.|::.|.:.
Human   201 FVEWQMGEQADGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFRAES 265

  Fly   223 VVPDRIIRLREAIASHDFQAFAEITMKDSNQFHAIALDTYPPCVYMNDVSHSIVSFVHDYNERMG 287
            |||.|:..:...|...||.:||::||||||||||..|||:||..|:|.:|..|:..||.:|...|
Human   266 VVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHG 330

  Fly   288 SYHAAYTFDAGPNACLYVLAEHVPHLLSAIQKVFPNDLADGGTYLRGLPI-PKVQDAESSKLDSL 351
            ....||||||||||.::.|.:.|...::|:...||.. ::|.|:|:||.: |....||.....::
Human   331 DTKVAYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPG-SNGDTFLKGLQVRPAPLSAELQAALAM 394

  Fly   352 DVHAKNAFRYIIHTKVGEGPKELSADNSLLI--NGLP 386
            : ......:|||.|:||.||:.|....:.|:  :|||
Human   395 E-PTPGGVKYIIVTQVGPGPQILDDPCAHLLGPDGLP 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvd	NP_001285295.1	PLN02407	1..322	CDD:178029	170/358 (47%)
Mvd	NP_001285295.1	GHMP_kinases_C	231..323	CDD:285715	42/91 (46%)
MVD	XP_011521388.1	PLN02407	10..371	CDD:178029	172/364 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145856
Domainoid	1	1.000	147	1.000	Domainoid score	I4528
eggNOG	1	0.900	-	-		E1_COG3407
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1843
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2236
Isobase	1	0.950	-	0	Normalized mean entropy	S814
OMA	1	1.010	-	-		QHG62270
OrthoDB	1	1.010	-	-		D1065019at2759
OrthoFinder	1	1.000	-	-		FOG0004204
OrthoInspector	1	1.000	-	-		oto90336
orthoMCL	1	0.900	-	-		OOG6_102327
Panther	1	1.100	-	-	LDO	PTHR10977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720