DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvd and Mvd

DIOPT Version :9

Sequence 1:	NP_001285295.1	Gene:	Mvd / 32520	FlyBaseID:	FBgn0030683	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_619597.2	Gene:	Mvd / 192156	MGIID:	2179327	Length:	401	Species:	Mus musculus

Alignment Length:	391	Identity:	198/391 - (50%)
Similarity:	260/391 - (66%)	Gaps:	12/391 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VTCVAPVNIALIKYWGKRHEELILPVNDSISMTLSTDELCAKTTVTASESFETNRMWLNGEEVPF 68
            |||.||||||:|||||||.|.||||:|.|:|:||..|:|...|||..|:.|..:|:||||.|...
Mouse    11 VTCTAPVNIAVIKYWGKRDEALILPINSSLSVTLHQDQLKTTTTVAISKDFTEDRIWLNGREEDV 75

  Fly    69 EESSRLQRCLNEVHRLAVASGSQKVPPT------WKLHIASVNNFPTAAGLASSAAGYACLVYSL 127
            .: .|||.||.|:.|||....|.:...|      :|:|:||||||||||||||||||||||.|:|
Mouse    76 GQ-PRLQACLREIRRLARKRRSTEDGDTLPLSLSYKVHVASVNNFPTAAGLASSAAGYACLAYTL 139

  Fly   128 SRLYDIPLNEELTTVARQGSGSACRSLYGGFVQWHRGALDDGSDSVARQIAPSDHWPNMHVLILV 192
            :::|.:  ..:|:.|||:||||||||||||||:|..|...||.||:||||||..|||.:.:||||
Mouse   140 AQVYGV--EGDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQIAPEWHWPQLRILILV 202

  Fly   193 VNDARKKTASTRGMQQAVKTSQLIKHRVDQVVPDRIIRLREAIASHDFQAFAEITMKDSNQFHAI 257
            |:..:|:|.||.|||.:|:||.|:|.|.:.|||:|:..:...|...|||.||::||||||||||.
Mouse   203 VSADKKQTGSTVGMQTSVETSTLLKFRAESVVPERMKEMTRCIQEQDFQGFAQLTMKDSNQFHAT 267

  Fly   258 ALDTYPPCVYMNDVSHSIVSFVHDYNERMGSYHAAYTFDAGPNACLYVLAEHVPHLLSAIQKVFP 322
            .|||:||..|:||.|..|:..||.:|...|....||||||||||.::.|.:.|...::|::..||
Mouse   268 CLDTFPPISYLNDTSRRIIQLVHRFNTHQGQTKVAYTFDAGPNAVIFTLEDTVAEFVAAVRHSFP 332

  Fly   323 NDLADGGTYLRGLPIPKVQDAESSKLDSLDVHAKNAFRYIIHTKVGEGPKEL--SADNSLLINGL 385
             ..|:|..:|:||.:..|..::..|.......:....:|||.|:||.||:.|  :.|:.|..:||
Mouse   333 -PAANGDKFLKGLQVAPVLLSDELKAALAVEPSPGGVQYIIATQVGPGPQVLDDTHDHLLGQDGL 396

  Fly   386 P 386
            |
Mouse   397 P 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvd	NP_001285295.1	PLN02407	1..322	CDD:178029	175/323 (54%)
Mvd	NP_001285295.1	GHMP_kinases_C	231..323	CDD:285715	44/91 (48%)
Mvd	NP_619597.2	PLN02407	9..338	CDD:178029	179/332 (54%)
		(R)-5-diphosphomevalonate binding. /evidence=ECO:0000250\|UniProtKB:O23722	24..27		2/2 (100%)
		(R)-5-diphosphomevalonate binding. /evidence=ECO:0000250\|UniProtKB:O23722	157..162		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835928
Domainoid	1	1.000	161	1.000	Domainoid score	I4013
eggNOG	1	0.900	-	-		E1_COG3407
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1843
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2090
Isobase	1	0.950	-	0	Normalized mean entropy	S814
OMA	1	1.010	-	-		QHG62270
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004204
OrthoInspector	1	1.000	-	-		oto93919
orthoMCL	1	0.900	-	-		OOG6_102327
Panther	1	1.100	-	-	LDO	PTHR10977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R783
SonicParanoid	1	1.000	-	-		X2949
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740