DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT6 and CCT2

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_012124.1	Gene:	CCT2 / 854664	SGDID:	S000001404	Length:	527	Species:	Saccharomyces cerevisiae

Alignment Length:	533	Identity:	149/533 - (27%)
Similarity:	272/533 - (51%)	Gaps:	26/533 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGD-IKITKDGNVLLHE 66
            |:.:...:....||..|.......|..:.|::::.|||||..|:|.|.:.: ..:|.||..:|..
Yeast     2 SVQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKS 66

  Fly    67 MQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEG-LHPRIMTDGFEKARDKA 130
            :.:.:|.|.::...|..|||..|||||:..:|..|||::|:..:.:. :||:.:.:|:..|...|
Yeast    67 IPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAA 131

  Fly   131 LEVLDQVKVPVEINK----KNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLH 191
            |:.|.:..|....:|    ::|:.:|.|:|.:|:.....|...::..||:|.:..:     .:|.
Yeast   132 LDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRLKGS-----TNLE 191

  Fly   192 MVELMEMQHKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEV-NSGFFYKTA 255
            .::::::.....:|:.|..|.::.....: :.|||:|||.||.||.:|:.:|.:: .:.|...:.
Yeast   192 HIQIIKILGGKLSDSFLDEGFILAKKFGN-NQPKRIENAKILIANTTLDTDKVKIFGTKFKVDST 255

  Fly   256 EEREAFVRAEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKR 320
            .:.....:||||.:..::.|:.:.      |.: ||  ||::.|...........||.::..|..
Yeast   256 AKLAQLEKAEREKMKNKIAKISKF------GIN-TF--INRQLIYDYPEQLFTDLGINSIEHADF 311

  Fly   321 RNMERLSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHT 385
            ..:|||:|..||..:::||:..:..||...|:.|.:|||..:.....||...:.||:::|....|
Yeast   312 EGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCKAGEACTIVLRGATDQT 376

  Fly   386 ITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIP 450
            :.:.:.::.|.|..::.|..:...|.|.|..|:.....:......|.||..|||:|||.||..:|
Yeast   377 LDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEAQNIDGKKSLAVEAFARALRQLP 441

  Fly   451 KTLAVNSGYDAQDTIVKL--TVEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSII 513
            ..||.|:|:|:.:.:.||  ::.:.:|..  ||||..|.......||:.::|.:|:.:::|.|..
Yeast   442 TILADNAGFDSSELVSKLRSSIYNGISTS--GLDLNNGTIADMRQLGIVESYKLKRAVVSSASEA 504

  Fly   514 ASNLLLVDEVMRA 526
            |..||.||.::||
Yeast   505 AEVLLRVDNIIRA 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	149/533 (28%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	148/529 (28%)
CCT2	NP_012124.1	TCP1_beta	5..520	CDD:239452	148/530 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810