DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT6 and CCT3

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_012520.1	Gene:	CCT3 / 853438	SGDID:	S000003551	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	534	Identity:	149/534 - (27%)
Similarity:	277/534 - (51%)	Gaps:	20/534 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHE 66
            |.:..:|...|.....||...||:|||.:.||:||.||||..:|||:...|.:.:|.||:.:|.|
Yeast     3 APVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILRE 67

  Fly    67 MQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSE-GLHPRIMTDGFEKARDKA 130
            :.:.||.|..:...|..||:..||||||.::|.||:|.|...||.| .:||.|:....:||...|
Yeast    68 IDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDA 132

  Fly   131 LEVLDQVKVPVEI-NKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTI-------ASADKTKP 187
            |||:.||..||:: |...:.::...|:.||.....::.:.::.::||.|:       ...:....
Yeast   133 LEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFE 197

  Fly   188 VDLHMVELMEMQHKSDT-DTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFF 251
            :|:.....:|.....|. |:::::|::::....||.|.:.:||..::..:..|||:|.|..:...
Yeast   198 IDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIE 262

  Fly   252 YKTAEEREAFVRAEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALR 316
            .:..|:....::.|.|.:....::::.::.:         ::|.:||:..::...|.|.|...||
Yeast   263 IEKEEDWNRILQIEEEQVQLMCEQILAVRPT---------LVITEKGVSDLAQHYLLKGGCSVLR 318

  Fly   317 RAKRRNMERLSLACGGTAMNSFDDLQEEHLG-YAGVVYEHVLGENKYTFVEDCKNPLSVTILIKG 380
            |.|:.:..|::...|.|.:|..:||:|..:| ..|:....::|:..::|:::||.|.:.||:::|
Yeast   319 RVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRG 383

  Fly   381 PNKHTITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADA 445
            .:|..:.:|...::|.:....|.:...:|.||.||.|:....:|......::|..:...||.|||
Yeast   384 GSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADA 448

  Fly   446 LLVIPKTLAVNSGYDAQDTIVKLTVEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSC 510
            :..||:||..|:|.|....:.:|..:........|:|...|:.:..|..|:::..::|:|.:.:.
Yeast   449 MECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTA 513

  Fly   511 SIIASNLLLVDEVM 524
            ...|..||.||:::
Yeast   514 IESACLLLRVDDIV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	148/533 (28%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	148/529 (28%)
CCT3	NP_012520.1	chap_CCT_gamma	4..533	CDD:274085	148/533 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810