DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT6 and CCT7

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_012424.1	Gene:	CCT7 / 853333	SGDID:	S000003647	Length:	550	Species:	Saccharomyces cerevisiae

Alignment Length:	552	Identity:	142/552 - (25%)
Similarity:	268/552 - (48%)	Gaps:	40/552 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEM 67
            :|.:|....:.::....:..||:|...:|:.::..|||.|:..::|:......|:.||..:|..:
Yeast     9 TIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLL 73

  Fly    68 QIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALE 132
            .:.||.|..:...|.|||...|||||:..:|.|||:|:|..:|.||:...::..|:.||...|:|
Yeast    74 DVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVE 138

  Fly   133 VLDQVKVPVEINKKN----LVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMV 193
            .::::.|.:...|.:    |...|.|::.:|:....||....:||:|||::...|    :|..::
Yeast   139 KINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRND----LDDKLI 199

  Fly   194 ELMEMQHKSDTDTQLVRGLVMDHG---ARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTA 255
            .:.::...:..::..:.|:.....   |.....||:..|..||:.||.||.:..:.|:....:..
Yeast   200 GIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHV 264

  Fly   256 EEREAFVRAEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKR 320
            |:.:|.|.||.:.|.:::::|.|...:         :::::..|..::....|...|....|...
Yeast   265 EDYQAIVDAEWQLIFEKLRQVEETGAN---------IVLSKLPIGDLATQFFADRNIFCAGRVSA 320

  Fly   321 RNMERLSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHT 385
            .:|.|:..|.||:..::..|::.||||...:..|..:|..:|...:.|....:.|:|::|..:..
Yeast   321 DDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQV 385

  Fly   386 ITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIP 450
            |.:::.::.|.:..:...:.:|.:|.|.||.|:.....|..:..||.||.::.:.|||.||.|||
Yeast   386 IAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIP 450

  Fly   451 KTLAVNSGYDAQDTIVKLTVEDRLSPELVGLDLATGEPMKPVDLG------VYDNYIVKKQILNS 509
            :.|..|:|:||.:.:.||.:......:..|:...|      .::|      |::..:||...|||
Yeast   451 RQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFET------ENIGDNFAKFVWEPALVKINALNS 509

  Fly   510 CSIIASNLLLVDEVM--------RAGMTSLKG 533
            .:...:.:|.|||.:        .|||...:|
Yeast   510 ATEATNLILSVDETITNKGSESANAGMMPPQG 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	141/549 (26%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	138/541 (26%)
CCT7	NP_012424.1	TCP1_eta	9..529	CDD:239456	138/538 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810