DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT6 and HSP60

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_013360.1	Gene:	HSP60 / 850963	SGDID:	S000004249	Length:	572	Species:	Saccharomyces cerevisiae

Alignment Length:	586	Identity:	123/586 - (20%)
Similarity:	224/586 - (38%)	Gaps:	128/586 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SAAKG---LQDVMRTNLGPKGTVKMLVSGAGDIKITKDG-----NVLLHEMQIQHPTASMIARAS 81
            |..||   |.:.:...|||||...::....|..||||||     :::|.: :.::..|.::...:
Yeast    36 SLLKGVETLAEAVAATLGPKGRNVLIEQPFGPPKITKDGVTVAKSIVLKD-KFENMGAKLLQEVA 99

  Fly    82 TAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALEVLDQVKVPVEINKK 146
            :..:::.|||||:..:|...:..::...::.|.:|..:..|.:.|.:|.:|.|...|..:..:::
Yeast   100 SKTNEAAGDGTTSATVLGRAIFTESVKNVAAGCNPMDLRRGSQVAVEKVIEFLSANKKEITTSEE 164

  Fly   147 NLVEVANTSLKTKVH--PALADLLTDVCVNAVLTIASADKTKPVDLHMVELMEMQHKSDTDTQLV 209
             :.:||..|.....|  ..||..:..|....|:||... :|...:|.:.|
Yeast   165 -IAQVATISANGDSHVGKLLASAMEKVGKEGVITIREG-RTLEDELEVTE--------------- 212

  Fly   210 RGLVMDHGARHPDMPKRLENAYILT--ANVSLEYEKAEVNSGFFYKTAEEREAFVR---AEREFI 269
             |:..|.|...|         |.:|  .:..:|:||.      ....:|::.:.::   ...|..
Yeast   213 -GMRFDRGFISP---------YFITDPKSSKVEFEKP------LLLLSEKKISSIQDILPALEIS 261

  Fly   270 DQRVKKVIELKRSVCDGTDKTFVLINQ-KGIDPISLDALAKEGILALRRAKRRN-MERLSLACGG 332
            :|..:.::.:...| ||......::|: :|  .:.:.|:...|.    ...|:| :..:::..||
Yeast   262 NQSRRPLLIIAEDV-DGEALAACILNKLRG--QVKVCAVKAPGF----GDNRKNTIGDIAVLTGG 319

  Fly   333 TAMNSFDDLQE-----EHLGYAGVVYEHVLGENKYTF------------VEDCKNPLSVT----- 375
            |......||:.     |:||....:  .|..|:....            :|..|..:.:|
Yeast   320 TVFTEELDLKPEQCTIENLGSCDSI--TVTKEDTVILNGSGPKEAIQERIEQIKGSIDITTTNSY 382

  Fly   376 ------------------ILIKGPNKHTITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRA-- 420
                              |.:.|.::..:.:.||...|.|.|....: ::.::||.|...|:|
Yeast   383 EKEKLQERLAKLSGGVAVIRVGGASEVEVGEKKDRYDDALNATRAAV-EEGILPGGGTALVKASR 446

  Fly   421 -YNELVAFKDTIKGKSRLAVQAFADALLVIPKTLAVNSGYDAQDTIVKLTVEDRLSPELV-GLDL 483
             .:|:|.  |....|  |.|.....|:....|.:..|:|.:....|.||.  |....:.. |.|.
Yeast   447 VLDEVVV--DNFDQK--LGVDIIRKAITRPAKQIIENAGEEGSVIIGKLI--DEYGDDFAKGYDA 505

  Fly   484 ATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLVDEV----------------MRAGMTSLK 532
            :..|....:..|:.|.:.|.:..|...|.:|| ||...||                |..||..:.
Yeast   506 SKSEYTDMLATGIIDPFKVVRSGLVDASGVAS-LLATTEVAIVDAPEPPAAAGAGGMPGGMPGMP 569

  Fly   533 G 533
            |
Yeast   570 G 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	122/583 (21%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	120/579 (21%)
HSP60	NP_013360.1	GroEL	25..548	CDD:239460	119/562 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900