DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT6 and cct2

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001006757.1	Gene:	cct2 / 448434	XenbaseID:	XB-GENE-1006535	Length:	535	Species:	Xenopus tropicalis

Alignment Length:	552	Identity:	155/552 - (28%)
Similarity:	275/552 - (49%)	Gaps:	55/552 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASISLL----------NPKAEFARAAQ---ALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAG 52
            |||:||.          ..|||.||.:.   |:||.        |::::.|||||..|:|:|...
Frog     1 MASLSLAPVNIFKAGADEEKAETARLSSFIGAIAIG--------DLVKSTLGPKGMDKILLSSGR 57

  Fly    53 D--IKITKDGNVLLHEMQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLH 115
            |  :.:|.||..:|..:.|.:|.|.::...|..|||..|||||:..:|..|||::|::.::..:|
Frog    58 DSTVTVTNDGATILKAIGIDNPAAQVLVDMSKVQDDEVGDGTTSVTVLAAELLREAEVLVARKIH 122

  Fly   116 PRIMTDGFEKARDKALEVLDQVKV----PVEINKKNLVEVANTSLKTKVHPALADLLTDVCVNAV 176
            |:.:..|:.:|...|.|.|....|    ..|..:.:|:.:|.|:|.:|:.....|..:.:.|.||
Frog   123 PQTIISGWRQATQVAREALLNASVDHGNDEEKFRCDLLNIARTTLSSKLLTHHKDHFSKLAVEAV 187

  Fly   177 LTIASADKTKPVDLHMVELMEMQHKSDTDTQLVRGLVMDH--GARHPDMPKRLENAYILTANVSL 239
            |.:..:.     :|..:.:::....|.|::.|..|.::|.  |.   :.|||:|||.||.||..:
Frog   188 LRLKGSG-----NLEAIHVIKKLGGSLTESYLDEGFLLDKKIGV---NQPKRIENAKILIANTGM 244

  Fly   240 EYEKAEVNSGFFYKTAEEREAFVR----AEREFIDQRVKKVIELKRSV-CDGTDKTFVLINQKGI 299
            :.:|.::   |..:...:..|.|.    ||:|.:.::|:::  ||..: |        .||::.|
Frog   245 DTDKIKI---FGSRVRVDSTAKVAEIELAEKEKMKEKVERI--LKHGINC--------FINRQLI 296

  Fly   300 DPISLDALAKEGILALRRAKRRNMERLSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTF 364
            ........|..|::|:..|....:|||:|..||...::||..:...||...::.|.::||:|...
Frog   297 YNYPEQLFATAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGTCKLIEEVMIGEDKLIH 361

  Fly   365 VEDCKNPLSVTILIKGPNKHTITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKD 429
            ........:.||:::|..:..:.:.:.::.|.|..:..|:.|...|.|.|..|:...:.:.....
Frog   362 FSGVAMGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDTRTVYGGGCSEMLMAHAVTELAI 426

  Fly   430 TIKGKSRLAVQAFADALLVIPKTLAVNSGYDAQDTIVKLTVEDRLSPELVGLDLATGEPMKPVDL 494
            ...||..:|:::||.||.::|..:|.|:|||:.|.:.:|...........|||:..|...:..:|
Frog   427 RTPGKESVAMESFAKALRMLPTIIADNAGYDSADLVSQLRAAHSEGKSTYGLDMKNGTIGEMGEL 491

  Fly   495 GVYDNYIVKKQILNSCSIIASNLLLVDEVMRA 526
            |:.:::.||:|:|.|.|..|..:|.||.:::|
Frog   492 GITESFQVKRQVLLSASEAAEVILRVDNIIKA 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	153/550 (28%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	150/546 (27%)
cct2	NP_001006757.1	TCP1_beta	11..527	CDD:239452	150/542 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910