DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT6 and CCT3

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	152/529 - (28%)
Similarity:	274/529 - (51%)	Gaps:	32/529 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQIQHP 72
            |.|.|..|..|  ..||.|.|.:.||:||.|||:..:|||:...|.|.:|.|||.:|.|:.:|||
  Fly    14 NTKRESGRKVQ--LENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREITVQHP 76

  Fly    73 TASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKA-RDKALEVLDQ 136
            .|..:...:..||:..|||||:.::|.||:|..|:.:|.:.:||.::...:.:| .|....:..|
  Fly    77 AAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALEDIVGHLQSQ 141

  Fly   137 VKVPVEI-NKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTK-PVDL-HMVELMEM 198
            :.:.::: :|..:.:|....:.||.....:||...:.::||.|:..::..: .||: ...::.::
  Fly   142 LSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDIKRYAKVEKI 206

  Fly   199 QHKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREAFVR 263
            ...:..::.:::|::::....||.|.:.:||..|:..:.||||:|.|..:.......::....::
  Fly   207 PGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQDFTRMLQ 271

  Fly   264 AEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMERLSL 328
            .|.||:.:....:|.:|..         ::..:||:..::...|.|.||.|:||.::.:..|::.
  Fly   272 IEEEFVQRICADIIAVKPD---------LVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIAR 327

  Fly   329 ACGGTAMNSFDDLQEEHLGY-AGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHTITQIKDA 392
            |||.|.:|..::|.|:.:|. ||:.....:|:..:|||.:||.|.:.|||::|.:|..:.:.:..
  Fly   328 ACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILNETERN 392

  Fly   393 IRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIPKTLAVNS 457
            ::|.|....|.:.:..||.|.||.|:.| ::|:..|. :||    ...|.|.||.:||:|||.|.
  Fly   393 LQDALHVARNLVLEPRLVAGGGAVEMAA-SQLLTRKQ-VKG----PYTAVAHALEIIPRTLAQNC 451

  Fly   458 GYDAQDTIVKLTVEDRLSPELVGLDLAT----GEPMKPVDLGV---YDNYIVKKQILNSCSIIAS 515
            |   .:||..||..........|..:..    ||..:.||:.|   ::...||.|...:....|.
  Fly   452 G---ANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAI 513

  Fly   516 NLLLVDEVM 524
            .||.:|:::
  Fly   514 LLLRIDDIV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	152/529 (29%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	152/529 (29%)
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	152/529 (29%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	152/529 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453453
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850