DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT6 and Cct4

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_877966.1	Gene:	Cct4 / 29374	RGDID:	727937	Length:	539	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	162/520 - (31%)
Similarity:	268/520 - (51%)	Gaps:	28/520 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQIQHPTASMIAR 79
            :.||....||||||.:.|.:||:|||||..||:..|.||:.||.||..:|.:||:.||.|.|:..
  Rat    29 KPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVE 93

  Fly    80 ASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALEVLDQVKVPVEI- 143
            .|.|||...|||||:.|::.|.||......|.:|:||.|:::.|:||.:|.||:|..:..||::
  Rat    94 LSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRPVQLS 158

  Fly   144 NKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMVELMEMQHKSDTDTQL 208
            :::.|:..|.|||.:||....:.||:.:.||||:.:........|||..:::::....:..|.:|
  Rat   159 DRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCEL 223

  Fly   209 VRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREAFVRAEREFIDQRV 273
            |.|||:.....:..: .|:|.|.|......|...|.::::........:.:..:|.||.:|...|
  Rat   224 VEGLVLTQKVANSGI-TRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLV 287

  Fly   274 KKVIELKRSVCDGTDKTFVLINQKGI-----DPISLDALAKEGILALRRAKRRNMERLSLACGGT 333
            |   ::|::.|:      ||:.||.|     ..::|..|.|..|:.::..:|.::|.:....|..
  Rat   288 K---QIKKTGCN------VLLIQKSILRDALSDLALHFLNKMKIMVVKDIEREDIEFICKTIGTK 343

  Fly   334 AMNSFDDLQEEHLGYAGVVYEHVL-GENKYTFVEDCKNP-LSVTILIKGPNKHTITQIKDAIRDG 396
            .:...|....:.||.|.:..|..| |..|...:..|.:| .:|||:::|.||..|.:.:.:|.|.
  Rat   344 PVAHIDQFTPDMLGSAELAEEVSLNGSGKLFKITGCTSPGKTVTIVVRGSNKLVIEEAERSIHDA 408

  Fly   397 LRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIPKTLAVNSGYDA 461
            |..|...:..:||:.|.||.|:.....|..:..|:.|.....|:|||||:.|||.|||.|:|.:.
  Rat   409 LCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNP 473

  Fly   462 QDTIVKLTVEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLVDEVMRA 526
            ..|:.:|........:..|:::..|        |:  :.|:::.::....:..|.|.|..|.:|:
  Rat   474 ISTVTELRNRHAQGEKTTGINVRKG--------GI--SNILEEMVVQPLLVSVSALTLATETVRS 528

Fly 527 526
Rat 529 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	162/520 (31%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	162/520 (31%)
Cct4	NP_877966.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		TCP1_delta	25..538	CDD:239454	162/520 (31%)
		Cpn60_TCP1	44..539	CDD:278544	154/505 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820