DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT6 and Tcp1

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_036802.1	Gene:	Tcp1 / 24818	RGDID:	3832	Length:	556	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	145/538 - (26%)
Similarity:	280/538 - (52%)	Gaps:	30/538 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PKAEFARAAQALAI---NISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQIQ 70
            |.:.|...:...||   |:.||..:.::::::|||.|..||||...||:.||.||..:|..::::
  Rat     4 PLSVFGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVE 68

  Fly    71 HPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALEVLD 135
            ||.|.::...:..||...|||||:.|::..||||.||..:.:.:||..:..|:..|..:|:..::
  Rat    69 HPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYIN 133

  Fly   136 QVKV--PVEINKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASAD-KTKP-VDLHMVELM 196
            :..:  ..|:.:..|:..|.||:.:|:.....|...::.|:|||.:...| :.:| ..::.|.::
  Rat   134 ENLIINTDELGRDCLINAAKTSMSSKIIGINGDFFANMVVDAVLAVKYTDIRGQPRYPVNSVNIL 198

  Fly   197 EMQHKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREAF 261
            :...:|..::.|:.|..::.......|.||:.||.|...:.||:..|.::.........|:.:..
  Rat   199 KAHGRSQIESMLINGYALNCVVGSQGMLKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQI 263

  Fly   262 VRAEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMERL 326
            .:.|.:...:|::|::      ..|.:   |::...|||.:.|....:.|.:|:||..:|:::|:
  Rat   264 RQRESDITKERIQKIL------ATGAN---VILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRI 319

  Fly   327 SLACGGTAMNSFDDLQEEH------LGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHT 385
            :.|.|.:.:::..:|:.|.      ||.|..|.:..:.:::...:::.|...|.:|:::|.|...
  Rat   320 AKASGASILSTLANLEGEETFEATMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFM 384

  Fly   386 ITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIP 450
            ..:::.::.|.|..:...:..|::|||.||.|......|..:..::..:.:||:..||.:|||||
  Rat   385 CDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIP 449

  Fly   451 KTLAVNSGYDAQDTIVKLTV---EDRLSPE-----LVGLDLATGEPMKPVDLGVYDNYIVKKQIL 507
            .|||||:..|:.|.:.||..   |.:::||     .:||||..|:|......||::..|||.:.|
  Rat   450 NTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVHGKPRDNKQAGVFEPTIVKVKSL 514

  Fly   508 NSCSIIASNLLLVDEVMR 525
            ...:..|..:|.:|::::
  Rat   515 KFATEAAITILRIDDLIK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	145/538 (27%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	145/538 (27%)
Tcp1	NP_036802.1	TCP1_alpha	9..535	CDD:239451	143/533 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810