DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT6 and cct3

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_775357.1	Gene:	cct3 / 192327	ZFINID:	ZDB-GENE-020419-5	Length:	543	Species:	Danio rerio

Alignment Length:	526	Identity:	153/526 - (29%)
Similarity:	277/526 - (52%)	Gaps:	24/526 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQIQHP 72
            |.|.|..|..|  ..||||||.:.|::||.|||:..:|||:...|.|.:|.|||.:|.|:|:|||
Zfish    12 NIKRESGRKVQ--IGNISAAKTIADIIRTCLGPRAMMKMLLDPMGGIVMTNDGNAILREIQVQHP 74

  Fly    73 TASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALEVLDQV 137
            .|..:...|..||:..|||||:.::|.||:|..|:.:|.:.:||.::...:.:|.|..|.:|..:
Zfish    75 AAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEQFLEQQMHPTVVIGAYRQALDDMLNILKDI 139

  Fly   138 KVPVEI-NKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMVELMEMQHK 201
            ..||:: |:..::::.|:::.||.....:.|..::.::||.|: ..|:....::.:.:..:::..
Zfish   140 STPVDVSNRDMMLKIINSAINTKALSRWSTLACNIALDAVRTV-ELDENGREEIDIKKYAKVEKV 203

  Fly   202 SD---TDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREAFVR 263
            ..   .|:.::||::::....||.|.:.::|..|:..:.||||:|.|..:.......|:....::
Zfish   204 PGGIIEDSCVLRGVMVNKDVTHPRMRRLIKNPRIVLLDCSLEYKKGESQTDIEIAREEDFARILQ 268

  Fly   264 AEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMERLSL 328
            .|.|::.|..:.:|.||..         ::..:|||..::...|.|..|.|:||.::.:..|::.
Zfish   269 MEEEYVQQICEDIIRLKPD---------LIFTEKGISDLAQHYLMKANITAIRRIRKTDNNRIAR 324

  Fly   329 ACGGTAMNSFDDLQEEHLGYAGVVYE-HVLGENKYTFVEDCKNPLSVTILIKGPNKHTITQIKDA 392
            |||....:..|:|.|..:|....::| ..:|:..:|||.:||:|.:.|||::|.:|..:.:::..
Zfish   325 ACGARIASRTDELTENDVGTGTGLFEVKKIGDEYFTFVTECKDPKACTILLRGASKEILAEVERN 389

  Fly   393 IRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIPKTLAVNS 457
            ::|.::...|.:.|..|:||.||.|:...:.|......:.|..:...:|.|.||.|:|:||..|.
Zfish   390 LQDAMQVCRNVLLDPYLLPGGGAVEMEVSHRLTERSRAMTGVEQWPYRAVAQALEVVPRTLIQNC 454

  Fly   458 GYDAQDTIVKL----TVEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLL 518
            |..|...:..|    |.|...|   .|::..||.......||:::...||.|...:....|..||
Zfish   455 GASAIRVLTSLRAKHTQEGNSS---WGVNGETGTLADMEQLGIWEPLAVKAQTYKTAVETAILLL 516

  Fly   519 LVDEVM 524
            .:|:::
Zfish   517 RIDDIV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	153/526 (29%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	153/526 (29%)
cct3	NP_775357.1	chap_CCT_gamma	5..528	CDD:274085	153/526 (29%)
cct3	NP_775357.1	TCP1_gamma	5..524	CDD:239453	153/526 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820