DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT6 and Cct6b

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_033969.2	Gene:	Cct6b / 12467	MGIID:	1329013	Length:	531	Species:	Mus musculus

Alignment Length:	532	Identity:	342/532 - (64%)
Similarity:	440/532 - (82%)	Gaps:	2/532 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLH 65
            ||:|.:.||.||..|:..|||:||.||:|||||:|..|||||.:|||||||||||:|||||||||
Mouse     1 MAAIKIANPGAEVTRSQAALAVNICAARGLQDVLRPTLGPKGALKMLVSGAGDIKLTKDGNVLLH 65

  Fly    66 EMQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKA 130
            ||||||||||:||:.:.|||..||||||:.|::|||||||||:|:||||||||:|:||:.|:.||
Mouse    66 EMQIQHPTASIIAKVAAAQDHVTGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFDVAKTKA 130

  Fly   131 LEVLDQVKVPVEINKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMVEL 195
            |||||::||..|:.::.|::||.|||:||||..|||:||:..|::||.|....  .|:||.|||:
Mouse   131 LEVLDEIKVQKEMKREILLDVARTSLQTKVHAELADILTEAVVDSVLAIRRPG--VPIDLFMVEI 193

  Fly   196 MEMQHKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREA 260
            :||:|||:|||||:||||:|||||||.|.|::.:|||||.||||||||.||:|||||||.||:|.
Mouse   194 VEMRHKSETDTQLIRGLVLDHGARHPRMRKQVRDAYILTCNVSLEYEKTEVSSGFFYKTVEEKEK 258

  Fly   261 FVRAEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMER 325
            .|:|||:||:.||:|:|:||:.||..::|.||:||||||||:||:.|||..|:|||||||||:||
Mouse   259 LVKAERKFIEDRVQKIIDLKQKVCAESNKGFVVINQKGIDPVSLEMLAKHNIVALRRAKRRNLER 323

  Fly   326 LSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHTITQIK 390
            |:|||||.|:|||:.|.||.||:||:|:|:.|||.|:||:|||.||||||:|:|||||||:.|||
Mouse   324 LTLACGGLAVNSFEGLSEECLGHAGLVFEYALGEEKFTFIEDCVNPLSVTLLVKGPNKHTLIQIK 388

  Fly   391 DAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIPKTLAV 455
            ||:||||||:.|.|.|..:||||||.||.....||.:|..::|:.||.:||||||||:|||.||.
Mouse   389 DALRDGLRAVKNAIEDGCVVPGAGAVEVAIAEALVNYKHRVQGRVRLGIQAFADALLIIPKVLAQ 453

  Fly   456 NSGYDAQDTIVKLTVEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLV 520
            |||||.|:|::|:..:...|.||:|:||.|||||...:.|::|||.|||.:|:||::||:|:|||
Mouse   454 NSGYDLQETLIKIQTKHAESKELLGIDLNTGEPMAAAEAGIWDNYCVKKHLLHSCTVIATNILLV 518

  Fly   521 DEVMRAGMTSLK 532
            ||:|||||:||:
Mouse   519 DEIMRAGMSSLR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	339/528 (64%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	335/520 (64%)
Cct6b	NP_033969.2	chap_CCT_zeta	3..530	CDD:274088	339/528 (64%)
Cct6b	NP_033969.2	TCP1_zeta	8..526	CDD:239458	335/519 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831984
Domainoid	1	1.000	710	1.000	Domainoid score	I118
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	761	1.000	Inparanoid score	I544
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54122
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0003188
OrthoInspector	1	1.000	-	-		otm42618
orthoMCL	1	0.900	-	-		OOG6_101716
Panther	1	1.100	-	-	O	PTHR11353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2146
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770